{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:57:22Z","timestamp":1791255442119,"version":"4.1.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Langerhans cell histiocytosis (LCH) is a rare proliferative systemic disease characterized by the growth of abnormal dendritic cells and wide-ranging organ involvement. This condition can affect individuals of all ages, but most commonly children, with a peak incidence in toddlers. Symptoms may vary depending on the affected organ or system.<\/jats:p><jats:p>\n          Case Report\u2003A 43-year-old man presented with a left temporal stabbing headache unresponsive to management with therapy and nonsteroidal anti-inflammatory drugs. Initial evaluation revealed a contrast-enhanced left temporal extra-axial lesion with bone and muscle compromise. Differential diagnoses, including multiple myeloma, were explored. Initial laboratory tests and imaging studies showed no other abnormalities, except for splenomegaly and a residual granuloma in the left lung. En bloc resection of the lesion was recommended. The patient underwent surgical intervention, which included resection of the dural lesion and all borders of an infiltrating tumor within the temporalis muscle and the affected portion of the left temporal bone. Posterior pathological examination revealed LCH. Postoperative course was uneventful. Follow-up appointments were scheduled after pathology results confirmed the diagnosis. Patient has continued follow-up for the following 3 months after the surgical procedure. Further evaluations are pending.<\/jats:p><jats:p>\n          Discussion\u2003This case report corresponds to a patient with LCH. These patients are individualized and stratified based on local or systemic involvement to determine the most appropriate type of management. This is a rare case as LCH is rare in older patients and the initial presented lesion initially mimicked a meningioma; however, its atypical behavior and associated lytic compromise led to consideration of possible differential diagnoses.<\/jats:p><jats:p>\n          Conclusion\u2003LCH can present with lytic bone lesions, mimicking other conditions, including infiltrative neoplastic lesions. Early diagnosis and appropriate surgical management are essential for optimal patient outcomes. Long-term follow-up is crucial to monitor disease progression and response to treatment.<\/jats:p>","DOI":"10.1055\/s-0044-1786360","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T23:00:16Z","timestamp":1714518016000},"page":"e43-e47","source":"Crossref","is-referenced-by-count":2,"title":["Langerhans Cell Histiocytosis Mimicking a Meningeal Lesion with Temporal Bone and Muscle Compromise in an Adult Patient: A Case Report"],"prefix":"10.1055","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2897-1378","authenticated-orcid":false,"given":"Alejandro","family":"Dur\u00e1n-Ojeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NeuroAxis SAS, Bogot\u00e1, Colombia"},{"name":"Department of Clinical Epidemiology and Biostatics, Universidad de los Andes, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Arce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NeuroAxis SAS, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-5578","authenticated-orcid":false,"given":"Santiago","family":"Campos-Fajardo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NeuroAxis SAS, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Jacomussi-Alzate","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NeuroAxis SAS, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Fundaci\u00f3n Universitaria de Ciencias de la Salud, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-7604","authenticated-orcid":false,"given":"Cristhian","family":"Rinc\u00f3n-Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NeuroAxis SAS, Bogot\u00e1, Colombia"},{"name":"Department of Neurosurgery, Universidad Nacional de Colombia, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1111\/cas.13817","article-title":"Langerhans cell histiocytosis in adults: advances in pathophysiology and treatment","volume":"109","author":"M Kobayashi","year":"2018","journal-title":"Cancer Sci"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.hoc.2015.06.005","article-title":"Clinical characteristics and treatment of Langerhans cell histiocytosis","volume":"29","author":"C Monsereenusorn","year":"2015","journal-title":"Hematol Oncol Clin North Am"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1016\/j.clml.2020.08.007","article-title":"Highlights of the management of adult histiocytic disorders: Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, and hemophagocytic lymphohistiocytosis","volume":"21","author":"H A Salama","year":"2021","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.bbmt.2009.11.014","article-title":"Histiocytic disorders: recent insights into pathophysiology and practical guidelines","volume":"16","author":"A Filipovich","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"14","key":"ref5","doi-asserted-by":"crossref","first-page":"18678","DOI":"10.18632\/oncotarget.7892","article-title":"Langerhans cell histiocytosis in adults: a case report and review of the literature","volume":"7","author":"C Lian","year":"2016","journal-title":"Oncotarget"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/ped.12380","article-title":"Recent advances in Langerhans cell histiocytosis","volume":"56","author":"A Morimoto","year":"2014","journal-title":"Pediatr Int"},{"key":"ref7","first-page":"154","volume-title":"Langerhans cell histiocytosis of bone","author":"S Weitzman","year":"2005"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12185-009-0420-4","article-title":"Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems","volume":"90","author":"S Imashuku","year":"2009","journal-title":"Int J Hematol"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/S0959-8049(03)00672-5","article-title":"Langerhans cell histiocytosis in adults. 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