{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:26:43Z","timestamp":1792614403054,"version":"4.5.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n            Background\u2003Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) criteria were launched nearly 20 years ago. Following the revised conceptual definition of sepsis and subsequent omission of systemic inflammatory response syndrome (SIRS) score from the latest sepsis diagnostic criteria, we omitted the SIRS score and proposed a modified version of JAAM DIC criteria, the JAAM-2 DIC criteria.<\/jats:p><jats:p>\n            Objectives\u2003To validate and compare performance between new JAAM-2 DIC criteria and conventional JAAM DIC criteria for sepsis.<\/jats:p><jats:p>\n            Methods\u2003We used three datasets containing adult sepsis patients from a multicenter nationwide Japanese cohort study (J-septic DIC, FORECAST, and SPICE-ICU registries). JAAM-2 DIC criteria omitted the SIRS score and set the cutoff value at \u22653 points. Receiver operating characteristic (ROC) analyses were performed between the two DIC criteria to evaluate prognostic value. Associations between in-hospital mortality and anticoagulant therapy according to DIC status were analyzed using propensity score weighting to compare significance of the criteria in determining introduction of anticoagulants against sepsis.<\/jats:p><jats:p>\n            Results\u2003Final study cohorts of the datasets included 2,154, 1,065, and 608 sepsis patients, respectively. ROC analysis revealed that curves for both JAAM and JAAM-2 DIC criteria as predictors of in-hospital mortality were almost consistent. Survival curves for the anticoagulant and control groups in the propensity score-weighted prediction model diagnosed using the two criteria were also almost entirely consistent.<\/jats:p><jats:p>\n            Conclusion\u2003JAAM-2 DIC criteria were equivalent to JAAM DIC criteria regarding prognostic and diagnostic values for initiating anticoagulation. The newly proposed JAAM-2 DIC criteria could be potentially alternative criteria for sepsis management.<\/jats:p>","DOI":"10.1055\/s-0044-1786808","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T01:55:54Z","timestamp":1715392554000},"page":"1003-1012","source":"Crossref","is-referenced-by-count":31,"title":["Proposal and Validation of a Clinically Relevant Modification of the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Diagnostic Criteria for Sepsis"],"prefix":"10.1055","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4021","authenticated-orcid":false,"given":"Kazuma","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Umemura","sequence":"additional","affiliation":[{"name":"Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan"},{"name":"Department of Emergency and Critical Care Medicine, Azumino Red Cross Hospital, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-3342","authenticated-orcid":false,"given":"Takeshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineji","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-4088","authenticated-orcid":false,"given":"Toshiaki","family":"Iba","sequence":"additional","affiliation":[{"name":"Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ohtomo","sequence":"additional","affiliation":[{"name":"National Disaster Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kitakyushu City Yahata Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Mayumi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Ishikura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Fukuoka University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizoh","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Graduate School of Emergency Medical System, Kokushikan University, Tama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan"},{"name":"Department of Acute and Critical Care Medicine, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"M Levi","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40560-016-0169-9","article-title":"Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013","volume":"4","author":"M Hayakawa","year":"2016","journal-title":"J Intensive Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.thromres.2019.04.025","article-title":"Role of disseminated intravascular coagulation in severe sepsis","volume":"178","author":"S Gando","year":"2019","journal-title":"Thromb Res"},{"issue":"49","key":"ref4","first-page":"265","article-title":"Criteria for diagnosis of DIC based on the analysis of clinical and laboratory findings in 345 DIC patients collected by the Research Committee on DIC in Japan","volume":"49","author":"N Kobayashi","year":"1983","journal-title":"Bibl Haematol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"F B Taylor Jr","year":"2001","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ams2.411","article-title":"Diagnosis of sepsis-induced disseminated intravascular coagulation and coagulopathy","volume":"6","author":"T Iba","year":"2019","journal-title":"Acute Med Surg"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-0038-1676610","article-title":"External validation of the two newly proposed criteria for assessing coagulopathy in sepsis","volume":"119","author":"K Yamakawa","year":"2019","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.CCM.0000202209.42491.38","article-title":"A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria","volume":"34","author":"S Gando","year":"2006","journal-title":"Crit Care Med"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.CCM.0000295317.97245.2D","article-title":"Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: results of a multicenter, prospective survey","volume":"36","author":"S Gando","year":"2008","journal-title":"Crit Care Med"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/shk.0b013e31804f7844","article-title":"SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia","volume":"28","author":"H Ogura","year":"2007","journal-title":"Shock"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","article-title":"American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"20","year":"1992","journal-title":"Crit Care Med"},{"issue":"17","key":"ref12","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMoa1415236","article-title":"Systemic inflammatory response syndrome criteria in defining severe sepsis","volume":"372","author":"K M Kaukonen","year":"2015","journal-title":"N Engl J Med"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13054-018-2186-7","article-title":"Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study","volume":"22","author":"T Abe","year":"2018","journal-title":"Crit Care"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40560-020-00465-0","article-title":"Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)","volume":"8","author":"T Abe","year":"2020","journal-title":"J Intensive Care"},{"issue":"06","key":"ref16","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"R C Bone","year":"1992","journal-title":"Chest"},{"issue":"07","key":"ref17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"J L Vincent","year":"1996","journal-title":"Intensive Care Med"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","article-title":"Guidelines for the diagnosis and management of disseminated intravascular coagulation","volume":"145","author":"M Levi","year":"2009","journal-title":"Br J Haematol"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.thromres.2009.08.017","article-title":"Expert consensus for the treatment of disseminated intravascular coagulation in Japan","volume":"125","author":"H Wada","year":"2010","journal-title":"Thromb Res"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.thromres.2011.08.028","article-title":"Diagnosis and treatment of disseminated intravascular coagulation: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)","volume":"129","author":"M Di Nisio","year":"2012","journal-title":"Thromb Res"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/jth.12155","article-title":"Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines","volume":"11","author":"H Wada","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/1076029615591169","article-title":"Design and evaluation of new unified criteria for disseminated intravascular coagulation based on the Japanese Association for Acute Medicine Criteria","volume":"22","author":"Y Umemura","year":"2016","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-016-1468-1","article-title":"Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity","volume":"20","author":"T Iba","year":"2016","journal-title":"Crit Care"},{"issue":"09","key":"ref24","doi-asserted-by":"crossref","first-page":"e017046","DOI":"10.1136\/bmjopen-2017-017046","article-title":"New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey","volume":"7","author":"T Iba","year":"2017","journal-title":"BMJ Open"},{"issue":"06","key":"ref25","first-page":"1099","article-title":"Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. Comparison between sepsis and trauma","volume":"100","author":"S Kushimoto","year":"2008","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.thromres.2009.06.036","article-title":"Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma","volume":"124","author":"A Sawamura","year":"2009","journal-title":"Thromb Res"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.thromres.2010.06.004","article-title":"Prospective external validation of the new scoring system for disseminated intravascular coagulation by Japanese Association for Acute Medicine (JAAM)","volume":"126","author":"K Iwai","year":"2010","journal-title":"Thromb Res"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1160\/TH10-05-0293","article-title":"Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation","volume":"105","author":"T Takemitsu","year":"2011","journal-title":"Thromb Haemost"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1786808.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:25:57Z","timestamp":1730823957000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1786808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,10,28]]},"published-print":{"date-parts":[[2024,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1786808","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]}}}