{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:23:41Z","timestamp":1774139021468,"version":"3.50.1"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The current research aimed to evaluate the histopathological pulpal alterations in dogs' teeth following direct pulp capping using either mineral trioxide aggregate (MTA) or human placenta extract (HPE).<\/jats:p><jats:p>\n          Materials and Methods\u2003Forty-eight incisors with mature apices from four dogs were involved. The teeth were randomly allocated to three groups (n\u2009=\u200916) based on the material utilized for direct pulp capping: MTA, HPE, and Teflon as the negative control group. All involved teeth were capped and restored at the same session. Each group was subsequently divided into two subgroups (n\u2009=\u20098) based on the post treatment evaluation period: 2 and 4 weeks. The histopathologic changes in each specimen's pulp tissues, including pulp inflammation, hyperemia, necrosis, and dentin bridge development, were assessed. Then, all the data were statistically analyzed using chi-square, t-test, and one-way analysis of variance (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Results\u2003At 2 weeks, chronic inflammation was observed in 100% of MTA and 50% of HPE subgroups with a significant difference between them whereas the remaining 50% exhibited no inflammation. In contrast to Teflon that showed acute inflammation, remission of inflammation was time-dependent at both MTA and HPE subgroups as there was a substantial difference between the 2- and 4-weeks evaluation periods within the same group. However, throughout the initially observed 2 weeks, all subgroups exhibited essentially no complete calcified bridge; at 4 weeks, all MTA and HPE subgroups developed dentin bridge formation, with a significant difference between them regarding its thickness.<\/jats:p><jats:p>\n          Conclusion\u2003HPE is a promising pulp-capping material inducing less intense chronic inflammation accompanied with thicker dentine bridge formation in comparison to MTA.<\/jats:p>","DOI":"10.1055\/s-0044-1786841","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T22:46:22Z","timestamp":1719614782000},"page":"144-153","source":"Crossref","is-referenced-by-count":2,"title":["Histopathological Evaluation of Human Placental Extract as a Direct Pulp-Capping Material in Dogs' Teeth"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-6203","authenticated-orcid":false,"given":"Rehab Khalil","family":"Safy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Suez Canal University, Ismailia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Hamdy","family":"Ragab","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Suez Canal University, Ismailia Governorate, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-715X","authenticated-orcid":false,"given":"Heba Bahgat","family":"Abdel-Maksoud","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry, Suez Canal University, Ismailia Governorate, Egypt"},{"name":"Restorative Dentistry Department, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0022034516639276","article-title":"Managing carious lesions: consensus recommendations on terminology","volume":"28","author":"N P Innes","year":"2016","journal-title":"Adv Dent Res"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s00784-020-03521-z","article-title":"Histological evaluation of the regenerative potential of a novel treated dentin matrix hydrogel in direct pulp capping","volume":"25","author":"A A Holiel","year":"2021","journal-title":"Clin Oral Investig"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/iep.12385","article-title":"Biological evaluation of hesperidin for direct pulp capping in dogs' teeth","volume":"102","author":"E O Abo 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