{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:13Z","timestamp":1790716873224,"version":"4.1.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mechanisms of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) differ as CABG provides surgical collateralization and may prolong life by preventing future myocardial infarctions (MIs). However, evidence for CABG in patients with chronic total occlusion (CTO) has not been fully elucidated and the impact of PCI is discussed controversially.<\/jats:p>\n                  <jats:p>We performed a meta-analysis of studies comparing outcomes in patients with\/without multivessel disease undergoing CABG or PCI for CTO. The primary outcome was long-term all-cause mortality (\u22655 years). Secondary outcomes were MIs, repeat revascularization, cardiac mortality, major adverse cardiovascular events, and stroke, as well as short-term mortality (30 days\/in-hospital) and stroke. A pooled Kaplan\u2013Meier survival curve after reconstruction analysis was generated. Random-effects models were used.<\/jats:p>\n                  <jats:p>Six studies totaling 12,504 patients were included. In the pooled Kaplan\u2013Meier analysis, PCI showed a significantly higher risk of death in the follow-up compared with CABG (hazard ratio [HR]: 2.12, 95% confidence interval [CI]: 1.88\u20132.38, p\u2009&lt;\u20090.01). During the observation period, PCI was also associated with higher rates of MI (odds ratio [OR]: 2.86, 95% CI: 1.82\u20134.48, p\u2009&lt;\u20090.01) and more repeat revascularization (OR: 4.88, 95% CI: 1.99\u201311.91, p\u2009=\u20090.0005). The other outcomes did not show significant differences.<\/jats:p>\n                  <jats:p>CABG is associated with superior survival to PCI over time in patients with CTO who are eligible for both PCI and CABG. This survival advantage is associated with fewer events of MI and repeat revascularization.<\/jats:p>","DOI":"10.1055\/s-0044-1787014","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:15:53Z","timestamp":1715973353000},"page":"609-617","source":"Crossref","is-referenced-by-count":9,"title":["Coronary Artery Bypass Grafting versus Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion"],"prefix":"10.1055","volume":"73","author":[{"given":"Hristo","family":"Kirov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulio","family":"Caldonazo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tasoudis","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique","family":"Runkel","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Jr.","family":"Soletti","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Cancelli","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Dell'Aquila","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Mukharyamov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Doenst","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jena University Hospital, Jena, 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