{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:20:41Z","timestamp":1793330441941,"version":"4.5.0"},"reference-count":86,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spontaneous intracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high early mortality and significant early disability burden. Traditionally, outcome assessments after ICH have mirrored those of acute ischemic stroke, with 3 months post-ICH being considered a standard time point in most clinical trials, observational studies, and clinical practice. At this time point, the majority of ICH survivors remain with moderate to severe functional disability. However, emerging data suggest that recovery after ICH occurs over a more protracted course and requires longer periods of follow-up, with more than 40% of ICH survivors with initial severe disability improving to partial or complete functional independence over 1 year. Multiple other domains of recovery impact ICH survivors including cognition, mood, and health-related quality of life, all of which remain under studied in ICH. To further complicate the picture, the most important driver of mortality after ICH is early withdrawal of life-sustaining therapies, before initiation of treatment and evaluating effects of prolonged supportive care, influenced by early pessimistic prognostication based on baseline severity factors and prognostication biases. Thus, our understanding of the true natural history of ICH recovery remains limited. This review summarizes the existing literature on outcome trajectories in functional and nonfunctional domains, describes limitations in current prognostication practices, and highlights areas of uncertainty that warrant further research.<\/jats:p>","DOI":"10.1055\/s-0044-1787104","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T23:08:33Z","timestamp":1716592113000},"page":"298-307","source":"Crossref","is-referenced-by-count":19,"title":["Outcome Trajectories after Intracerebral Hemorrhage"],"prefix":"10.1055","volume":"44","author":[{"given":"Lourdes","family":"Carhuapoma","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Critical Care, The Johns Hopkins Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weil Cornell Medical College, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishank A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Critical Care, Departments of Neurology, Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"17","key":"ref1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1056\/NEJMra2201449","article-title":"Spontaneous intracerebral hemorrhage","volume":"387","author":"K N Sheth","year":"2022","journal-title":"N Engl J Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and 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