{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:38:53Z","timestamp":1782805133952,"version":"3.54.5"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The intricacies of nerve regeneration following injury have prompted increased research efforts in recent years, with a primary focus on elucidating regeneration mechanisms and exploring various surgical techniques. While many experimental animals have been used for these investigations, the rat continues to remain the most widely used model due to its cost-effectiveness, accessibility, and resilience against diseases and surgical\/anesthetic complications. A comprehensive evaluation of all the experimental rat models available in this context is currently lacking.<\/jats:p><jats:p>\n          Methods\u2003We summarize rat models of cranial nerves while furnishing descriptions of the intricacies of achieving optimal exposure.<\/jats:p><jats:p>\n          Results\u2003This review article provides an examination of the technical exposure, potential applications, and the advantages and disadvantages inherent to each cranial nerve model.<\/jats:p><jats:p>\n          Conclusion\u2003Specifically in the context of cranial nerve injury, numerous studies have utilized different surgical techniques to expose and investigate the cranial nerves in the rat.<\/jats:p>","DOI":"10.1055\/s-0044-1787729","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T22:59:33Z","timestamp":1718751573000},"page":"133-143","source":"Crossref","is-referenced-by-count":1,"title":["Experimental Cranial Nerve Models in the Rat"],"prefix":"10.1055","volume":"41","author":[{"given":"Huseyin","family":"Karagoz","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-0941","authenticated-orcid":false,"given":"Sara C.","family":"Chaker","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Lineaweaver","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, 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of the rat optic nerve as a brain injury model: combining electrophysiological and behavioral outcome","volume":"2","author":"R Duvdevani","year":"1990","journal-title":"Restor Neurol Neurosci"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jnr.22584","article-title":"Different spatial and temporal protein expressions of repulsive guidance molecule A and neogenin in the rat optic nerve after optic nerve crush with and without lens injury","volume":"89","author":"S Schnichels","year":"2011","journal-title":"J Neurosci Res"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10792-022-02476-2","article-title":"Optic nerve injury models under varying forces","volume":"43","author":"W Sun","year":"2023","journal-title":"Int Ophthalmol"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/MOT.0000000000000713","article-title":"Immunological considerations and concerns 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changes","volume":"53","author":"E Fernandez","year":"2003","journal-title":"Neurosurgery"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3171\/jns.1987.67.3.0428","article-title":"Oculomotor nerve regeneration in rats. Functional, histological, and neuroanatomical studies","volume":"67","author":"E Fernandez","year":"1987","journal-title":"J Neurosurg"},{"issue":"44","key":"ref12","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1073\/pnas.1910292116","article-title":"Myelin sheath structure and regeneration in peripheral nerve injury repair","volume":"116","author":"B Liu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1167\/iovs.18-24843","article-title":"Corneal neurotization improves ocular surface health in a novel rat model of neurotrophic keratopathy and corneal neurotization","volume":"59","author":"J Catapano","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1167\/iovs.03-0189","article-title":"Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy","volume":"44","author":"T Nagano","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","volume-title":"Gray's Anatomy: The Anatomical Basis of Clinical Practice, 41st (International edition) ed","author":"S Standring","year":"2016"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0278-2391(84)90111-3","article-title":"Evaluation of peripheral nerve regeneration following crushing or transection injuries","volume":"42","author":"D A Tyndall","year":"1984","journal-title":"J Oral Maxillofac Surg"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1038\/s41598-018-22628-8","article-title":"Fetal extracellular matrix nerve wraps locally improve peripheral nerve remodeling after complete transection and direct repair in rat","volume":"8","author":"T Ren","year":"2018","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"650761","DOI":"10.3389\/fnana.2021.650761","article-title":"Selective denervation of the facial dermato-muscular complex in the rat: experimental model and anatomical basis","volume":"15","author":"V Tereshenko","year":"2021","journal-title":"Front Neuroanat"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneumeth.2008.04.013","article-title":"Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needle","volume":"172","author":"M Kernisant","year":"2008","journal-title":"J Neurosci Methods"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/joor.12313","article-title":"Evidence-based outcomes following inferior alveolar and lingual nerve injury and repair: a systematic review","volume":"42","author":"E Kushnerev","year":"2015","journal-title":"J Oral Rehabil"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-2007-1000197","article-title":"Intraosseous repair of the inferior alveolar nerve in rats: an experimental model","volume":"14","author":"N J Curtis","year":"1998","journal-title":"J Reconstr Microsurg"},{"issue":"06","key":"ref22","doi-asserted-by":"crossref","first-page":"e246","DOI":"10.1016\/j.joms.2011.02.007","article-title":"Comparison of microsuture, interpositional nerve graft, and laser solder weld repair of the rat inferior alveolar nerve","volume":"69","author":"N J Curtis","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2334\/josnusd.19-0487","article-title":"Performance of Schwann cell transplantation into extracted socket after inferior alveolar nerve injury in a novel rat model","volume":"62","author":"T Ito","year":"2020","journal-title":"J Oral Sci"},{"issue":"12","key":"ref24","first-page":"694","article-title":"Photobiomodulation activates microglia\/astrocytes and relieves neuropathic pain in inferior alveolar nerve injury","volume":"41","author":"E Daigo","year":"2023","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"ref25","volume-title":"Anatomy, Head and Neck, Mental Nerve","author":"J D Nguyen","year":"2023"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.7150\/ijms.77484","article-title":"Effect of no-ozone cold plasma on regeneration after crushed mental nerve injury in rats","volume":"19","author":"S-Y Park","year":"2022","journal-title":"Int J Med Sci"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/cne.902950404","article-title":"Regenerative organization of the trigeminal ganglion following mental nerve section and repair in the adult rat","volume":"295","author":"J R Zuniga","year":"1990","journal-title":"J Comp Neurol"},{"key":"ref28","volume-title":"Anatomy, Head and Neck, Lingual Nerve","author":"S E Fagan","year":"2023"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"105128","DOI":"10.1016\/j.archoralbio.2021.105128","article-title":"Nociceptive receptors are expressed differently in trigeminal nociception after lingual nerve injury and unilateral external carotid artery occlusion in rats","volume":"126","author":"A Wanasuntronwong","year":"2021","journal-title":"Arch Oral Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1744-8069-8-23","article-title":"Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats","volume":"8","author":"A Katagiri","year":"2012","journal-title":"Mol Pain"},{"issue":"07","key":"ref31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/micr.31053","article-title":"Drop-off in axonal regeneration along the length of a cross-face nerve graft: an experimental study in rats","volume":"43","author":"L E Janes","year":"2023","journal-title":"Microsurgery"},{"issue":"06","key":"ref32","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1021\/acsbiomaterials.3c00222","article-title":"Effect of electrical stimulation on nerve-guided facial nerve regeneration","volume":"9","author":"G Choe","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"issue":"09","key":"ref33","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/jpm13091317","article-title":"Effect of metformin on the functional and electrophysiological recovery of crush injury-induced facial nerve paralysis in diabetic rats","volume":"13","author":"K H Sun","year":"2023","journal-title":"J Pers Med"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3892\/etm.2012.701","article-title":"Motor fiber organization in the extratemporal trunk of the facial nerve in rats: a retrograde fluoro-gold study","volume":"4","author":"L Chen","year":"2012","journal-title":"Exp Ther Med"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13037-018-0170-4","article-title":"Preserving the marginal mandibular branch of the facial nerve during submandibular region surgery: a cadaveric safety study","volume":"12","author":"D J Anthony","year":"2018","journal-title":"Patient Saf Surg"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3791\/59224","article-title":"Facial nerve surgery in the rat model to study axonal inhibition and regeneration","volume":"159","author":"S A Ali","year":"2020","journal-title":"J Vis Exp"},{"issue":"03","key":"ref37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/nmo.12076","article-title":"Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway","volume":"25","author":"B Bonaz","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fnins.2019.00911","article-title":"Vagus nerve stimulation in rodent models: an overview of technical considerations","volume":"13","author":"C M Noller","year":"2019","journal-title":"Front Neurosci"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"e202100197","DOI":"10.1002\/jbio.202100197","article-title":"Vagus nerve bundle stimulation using 1505-nm laser irradiation in an in-vivo rat model","volume":"15","author":"O Yetis","year":"2022","journal-title":"J Biophotonics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"109848","DOI":"10.1016\/j.pnpbp.2019.109848","article-title":"Efficient parameters of vagus nerve stimulation to enhance extinction learning in an extinction-resistant rat model of PTSD","volume":"99","author":"R R Souza","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"102","key":"ref41","first-page":"e53032","article-title":"Vagus nerve stimulation as a tool to induce plasticity in pathways relevant for extinction learning","volume":"e53032","author":"J E Childs","year":"2015","journal-title":"J Vis Exp"},{"key":"ref42","volume-title":"Neuroanatomy, Cranial Nerve 11 (Accessory)","author":"B Bordoni","year":"2023"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/jor.22693","article-title":"Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model","volume":"32","author":"K E Reuther","year":"2014","journal-title":"J Orthop Res"},{"issue":"08","key":"ref44","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jse.2014.12.029","article-title":"Effect of scapular dyskinesis on supraspinatus repair healing in a rat model","volume":"24","author":"K E Reuther","year":"2015","journal-title":"J Shoulder Elbow Surg"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jns.2014.10.006","article-title":"Comparison of hemihypoglossal- and accessory-facial neurorrhaphy for treating facial paralysis in rats","volume":"347","author":"D Li","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref46","volume-title":"Neuroanatomy, Cranial Nerve 12 (Hypoglossal)","author":"S Y Kim","year":"2023"},{"issue":"06","key":"ref47","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00221-020-05835-6","article-title":"Assessment of axonal sprouting and motor performance after hypoglossal-facial end-to-side nerve repair: experimental study in rats","volume":"238","author":"L Sarikcioglu","year":"2020","journal-title":"Exp Brain Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"105779","DOI":"10.1016\/j.archoralbio.2023.105779","article-title":"Age-related sex differences in tongue strength and muscle morphometry in a rat model","volume":"155","author":"A H Rohl","year":"2023","journal-title":"Arch Oral Biol"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/micr.1920090106","article-title":"Microvascular transfers of latissimus dorsi and serratus anterior muscles in rats","volume":"9","author":"J A de la Pena","year":"1988","journal-title":"Microsurgery"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/micr.1920120407","article-title":"Microvascular transfer of anterior and posterior gracilis muscles in rats","volume":"12","author":"K K Yim","year":"1991","journal-title":"Microsurgery"},{"issue":"03","key":"ref51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1098-2752(1996)17:3<128::AID-MICR5>3.0.CO;2-I","article-title":"Rat intercostal nerves as experimental nerve grafts","volume":"17","author":"T Ust\u00fcner","year":"1996","journal-title":"Microsurgery"},{"issue":"03","key":"ref52","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/micr.1014","article-title":"Vascular grafts in the rat model: an anatomic study","volume":"21","author":"B Blain","year":"2001","journal-title":"Microsurgery"},{"issue":"03","key":"ref53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/s-2001-14353","article-title":"Microsurgical flap models in the rat","volume":"17","author":"F Zhang","year":"2001","journal-title":"J Reconstr Microsurg"},{"issue":"03","key":"ref54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/01658107.2017.1367012","article-title":"Relative afferent pupillary defects in homonymous visual field defects caused by stroke of the occipital lobe using pupillometer","volume":"42","author":"G Takizawa","year":"2017","journal-title":"Neuroophthalmology"}],"container-title":["Journal of Reconstructive 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