{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:37:03Z","timestamp":1791387423553,"version":"4.3.3"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein present a patient initially suspected of multiple lytic skeletal metastasis of unknown primary on anatomical imaging. Metabolic imaging by [18F]-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) detected focal [18F]FDG uptake in the right thyroid nodule, mild [18F]FDG uptake in soft tissue lesion in the left inferior parathyroid region, and multiple nonavid osteolytic skeletal lesions. Fine-needle aspiration cytology of the right thyroid nodule showed papillary thyroid carcinoma (PTC). The patient had raised serum parathyroid hormone and serum calcium levels, suggesting parathyroid disease. [18F]-sodium fluoride (NaF)-PET\/CT showed a metabolic superscan pattern of hyperparathyroidism with brown tumors rather than metastatic lytic skeletal lesions. Patient underwent total thyroidectomy and bilateral central compartment clearance, along with soft tissue lesion resection in the left inferior parathyroid region. Finally, histopathology confirmed PTC classical variant with no aggressive histology features (pT1N0) for thyroid nodule and parathyroid adenoma for soft tissue lesion in the left inferior parathyroid region. The findings of the [18F]FDG and [18F]NaF-PET\/CT imaging were helpful for making a final diagnosis of synchronous thyroid cancer and parathyroid adenoma, which in turn guided the appropriate treatment strategy.<\/jats:p>","DOI":"10.1055\/s-0044-1787732","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T23:33:42Z","timestamp":1718408022000},"page":"220-224","source":"Crossref","is-referenced-by-count":6,"title":["Complimentary Role of [18F]FDG and [18F]NaF-PET\/CT in Evaluating Synchronous Thyroid Carcinoma and Parathyroid Adenoma with Brown Tumors"],"prefix":"10.1055","volume":"23","author":[{"given":"Yeshwanth","family":"Edamadaka","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul V.","family":"Parghane","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-2558","authenticated-orcid":false,"given":"Sandip","family":"Basu","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12149-023-01832-1","article-title":"Brown tumors in nuclear medicine: a systematic review","volume":"37","author":"N Jacquet-Francillon","year":"2023","journal-title":"Ann Nucl Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ejrnm.2016.03.001","article-title":"Multiple brown tumors mistaken for bone metastases. Computed tomography imaging findings","volume":"47","author":"L Mor\u00e1n","year":"2016","journal-title":"Egypt J Radiol Nucl Med"},{"issue":"04","key":"ref3","first-page":"337","article-title":"Diagnostic and prognostic value of F-18 FDG PET\/CT in patients with carcinoma of unknown primary","volume":"9","author":"N Bicakci","year":"2022","journal-title":"North Clin Istanb"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/jayao.2017.0114","article-title":"Hyperparathyroidism mimicking metastatic bone disease: a case report and review of literature","volume":"7","author":"M Gupta","year":"2018","journal-title":"J Adolesc Young Adult Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1477-7819-7-63","article-title":"Incidental thyroid lesions detected by FDG-PET\/CT: prevalence and risk of thyroid cancer","volume":"7","author":"J S Bae","year":"2009","journal-title":"World J Surg Oncol"},{"key":"ref6","first-page":"49","article-title":"Accidental detection of a parathyroid adenoma by fluorine-18 fluorodeoxyglucose positron emission tomography \/ computed tomography (FDG-PET\/CT)","volume":"14","author":"L S Freudenberg","year":"2005","journal-title":"Turk J Nucl Med"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3803\/EnM.2020.725","article-title":"Association of hyperparathyroidism and papillary thyroid cancer: a multicenter retrospective study","volume":"35","author":"C Jeong","year":"2020","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s13139-017-0488-3","article-title":"Dual pathologies of parathyroid adenoma and papillary thyroid cancer on fluorocholine and fluorodeoxyglucose PET\/CT","volume":"52","author":"N TK Thanseer","year":"2018","journal-title":"Nucl Med Mol Imaging"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00000658-200205000-00008","article-title":"Six hundred fifty-six consecutive explorations for primary hyperparathyroidism","volume":"235","author":"R Udelsman","year":"2002","journal-title":"Ann Surg"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4103\/jomfp.JOMFP_166_19","article-title":"A complex case of brown tumors as initial manifestation of primary hyperparathyroidism in a young female","volume":"23","author":"B S Manjunatha","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jbspin.2016.06.007","article-title":"Contribution of 18-FDG PET\/CT to brown tumor detection in a patient with primary hyperparathyroidism","volume":"84","author":"M Gahier Penhoat","year":"2017","journal-title":"Joint Bone Spine"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00774-019-01059-z","article-title":"18F-NaF-PET\/CT in patients with primary hyperparathyroidism and brown tumors","volume":"38","author":"C Graf","year":"2020","journal-title":"J Bone Miner Metab"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/RLU.0000000000000500","article-title":"Hyperparathyroidism and hungry bone syndrome revisited","volume":"39","author":"R Varma","year":"2014","journal-title":"Clin Nucl Med"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1787732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:19:36Z","timestamp":1730805576000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1787732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":13,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,8,20]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1787732","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]}}}