{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:23:49Z","timestamp":1793319829916,"version":"4.5.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Cerebellar ataxias comprise sporadic and genetic etiologies. Ataxia may also be a presenting feature in hereditary spastic paraplegias (HSPs).<\/jats:p><jats:p>\n          Objective\u2003To report a descriptive analysis of the frequency of different forms of cerebellar ataxia evaluated over 17 years in the Ataxia Unit of Universidade Federal de S\u00e3o Paulo, Brazil.<\/jats:p><jats:p>\n          Methods\u2003Charts of patients who were being followed from January 2007 to December 2023 were reviewed. We used descriptive statistics to present our results as frequencies and percentages of the overall analysis. Diagnosed patients were classified according to the following 9 groups: sporadic ataxia, spinocerebellar ataxias (SCAs), other autosomal dominant cerebellar ataxias, autosomal recessive cerebellar ataxias (ARCAs), mitochondrial ataxias, congenital ataxias, X-linked ataxias, HSPs, and others.<\/jats:p><jats:p>\n          Results\u2003There were 1,332 patients with ataxias or spastic paraplegias. Overall, 744 (55.85%) of all cases were successfully diagnosed: 101 sporadic ataxia, 326 SCAs, 20 of other autosomal dominant cerebellar ataxias, 186 ARCAs, 6 X-linked ataxias, 2 mitochondrial ataxias, 4 congenital ataxias, and 51 HSPs.<\/jats:p><jats:p>\n          Conclusion\u2003This study describes the frequency of cerebellar ataxias in a large group of patients followed for the past 17 years, of whom 55% obtained a definitive clinical or molecular diagnosis. Future demographic surveys in Brazil or Latin American remain necessary.<\/jats:p>","DOI":"10.1055\/s-0044-1787800","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T22:47:55Z","timestamp":1720133275000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Ataxias in Brazil: 17 years of experience in an ataxia center"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-8593","authenticated-orcid":false,"given":"Breno Kazuo","family":"Massuyama","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia Cl\u00ednica, Setor de Ataxias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-0107","authenticated-orcid":false,"given":"Maria Thereza Drumond","family":"Gama","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia Cl\u00ednica, Setor de Ataxias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-8309","authenticated-orcid":false,"given":"Thiago Yoshinaga Tonholo","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia Cl\u00ednica, Setor de Ataxias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-9243","authenticated-orcid":false,"given":"Pedro","family":"Braga-Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Faculdade de Medicina, Departamento de Cl\u00ednica M\u00e9dica, Fortaleza CE, Brazil."},{"name":"Universidade Estadual do Cear\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-8894","authenticated-orcid":false,"given":"Jos\u00e9 Luiz","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia Cl\u00ednica, Setor de Ataxias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-0831","authenticated-orcid":false,"given":"Orlando Graziani Povoas","family":"Barsottini","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Disciplina de Neurologia Cl\u00ednica, Setor de Ataxias, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1590\/0004-282x20130242","article-title":"Adult onset sporadic ataxias: a diagnostic challenge","volume":"72","author":"O GP Barsottini","year":"2014","journal-title":"Arq Neuropsiquiatr"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1474-4422(09)70305-9","article-title":"Sporadic ataxia with adult onset: classification and diagnostic criteria","volume":"9","author":"T Klockgether","year":"2010","journal-title":"Lancet Neurol"},{"issue":"06","key":"ref3","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s12311-019-01052-2","article-title":"The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task 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