{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:45:50Z","timestamp":1772030750981,"version":"3.50.1"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meckel's cave is a dural recess in the posteromedial portion of the middle cranial fossa, serving as a conduit for the trigeminal nerve and hosting various pathologies. The radiological diagnosis of Meckel's cave pathologies is often challenging, especially when they are atypical and rarely encountered. Here, we discuss the case of a 41-year-old woman who presented with right hemifacial pain, numbness, and binocular diplopia. Imaging features suggested a T2 hypointense, T1 hyperintense, and nonenhancing mass in the right Meckel's cave. Intraoperatively, an extra-axial black mass was observed, suggestive of melanoma, which was radically excised. Further postoperative workup and biopsy revealed it was a primary central nervous system (CNS) malignant melanoma, an exceedingly rare condition. Due to the rarity of the disease, a consensus regarding treatment regimens is lacking. This case report underscores the significance of considering uncommon diagnoses when faced with unusual radiological findings and emphasizes the importance of aggressive surgical resection and the evolving landscape of adjuvant treatments for primary CNS melanomas.<\/jats:p>","DOI":"10.1055\/s-0044-1787822","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T22:55:31Z","timestamp":1718319331000},"page":"563-566","source":"Crossref","is-referenced-by-count":1,"title":["Primary CNS Melanoma of Meckel's Cave: A Rare Case with Literature Review"],"prefix":"10.1055","volume":"19","author":[{"given":"Charan","family":"Makkina","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-6400","authenticated-orcid":false,"given":"Jeena","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Prabhu","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-9393","authenticated-orcid":false,"given":"Ranjani","family":"Jayachandran","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"issue":"05","key":"ref1","first-page":"492","article-title":"Primary extracutaneous malignant melanoma: a comprehensive review with emphasis on treatment","volume":"27","author":"A Thoelke","year":"2004","journal-title":"Onkologie"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"D N Louis","year":"2021","journal-title":"Neuro-oncol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/1523-1747.ep12260111","article-title":"The distribution of melanocytes in the leptomeninges of the human brain","volume":"82","author":"M H Goldgeier","year":"1984","journal-title":"J Invest Dermatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0190-9622(87)80091-9","article-title":"Cutaneous malignant melanoma","volume":"16","author":"A W Kopf","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1590\/S0004-282X2004000200030","article-title":"Primary melanoma of Meckel's cave: case report","volume":"62","author":"A Falavigna","year":"2004","journal-title":"Arq Neuropsiquiatr"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0090-3019(91)90011-W","article-title":"Primary malignant melanoma of the Gasserian ganglion associated with neurofibromatosis","volume":"35","author":"F S Haddad","year":"1991","journal-title":"Surg Neurol"},{"issue":"03","key":"ref7","first-page":"153","article-title":"Nonsyndromic primary diffuse leptomeningeal melanomatosis in a child","volume":"15","author":"S Tavana Rad","year":"2021","journal-title":"Iran J Child Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"581.e15","DOI":"10.1016\/j.wneu.2016.06.039","article-title":"Primary amelanotic leptomeningeal melanomatosis in a child: a rare but severe disease","volume":"92","author":"A Szathmari","year":"2016","journal-title":"World Neurosurg"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0887-8994(94)00155-U","article-title":"Primary malignant melanoma of meninges: atypical presentation of subacute meningitis","volume":"12","author":"P Nicolaides","year":"1995","journal-title":"Pediatr Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.wneu.2018.04.153","article-title":"What tactics should a surgeon choose to treat a black extracerebral tumor? A case report of psammomatous melanotic schwannoma of the Meckel cave and literature review","volume":"116","author":"G I Moisak","year":"2018","journal-title":"World Neurosurg"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3348\/kjr.2013.14.2.343","article-title":"F-18 fluorodeoxyglucose PET\/CT and post hoc PET\/MRI in a case of primary meningeal melanomatosis","volume":"14","author":"H J Lee","year":"2013","journal-title":"Korean J Radiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.wneu.2018.06.138","article-title":"Primary solitary intracranial malignant melanoma: a systematic review of literature","volume":"117","author":"N Arai","year":"2018","journal-title":"World Neurosurg"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/CMR.0b013e328352dbef","article-title":"Melanoma in the brain: biology and therapeutic options","volume":"22","author":"G T Gibney","year":"2012","journal-title":"Melanoma Res"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1787822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:12:17Z","timestamp":1730808737000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1787822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":13,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,8,27]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1787822","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,13]]}}}