{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:56:15Z","timestamp":1792828575886,"version":"4.5.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Pituitary adenoma is the most common disease that affects the gland and may be classified as functional\/nonsecretory tumors. Inflammatory\/infective causes may also affect the pituitary gland. The 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (F18-FDG PET\/CT) may have an incremental value in assessing these lesions and in determining their clinical significance.<\/jats:p><jats:p>\n          Aim\u2003This article assesses the utility of F18-FDG PET\/CT in detecting and determining clinical profile of pituitary lesions with abnormal uptake.<\/jats:p><jats:p>\n          Methodology\u2003Retrospective analysis of all patients who underwent F18-FDG PET\/CT from January 2015 to January 2023 was done. Those with abnormal pituitary uptake (standardized uptake value [SUV]\u2009&gt;\u20092.5) were included in the study. SUV value along with relevant anatomical details, biochemical parameters, histopathological details, and follow-up imaging were analyzed.<\/jats:p><jats:p>\n          Results\u2003Among 15,085 studies, a total of 36 patients (21 males\/15 females, average age 47.36 years, range: 17\u201375 years) with pituitary uptake (0.23%) were included. Out of 36 patients, causes are primary pituitary tumor (21\/36, 58%), tubercular hypophysitis (3\/36, 8%), lymphocytic hypophysitis (2\/36, 6%), lymphomatous involvement (2\/36, 6%), autoimmune hypophysitis (1\/36, 3%), questionable significance\/incidental (4\/36, 11%), and metastasis (3\/36, 8%)\u2014one each from neuroendocrine tumor ileum, chondrosarcoma, and adenocarcinoma lung. There was no difference in the SUV range between the different etiologies.<\/jats:p><jats:p>Among 21 patients with pituitary tumor, biochemical evaluation was done in 19 patients. Two patients were lost to follow-up and did not have biochemical evaluation. Among them, 8 underwent endoscopic transsphenoidal radical excision and 1 patient had PET-CT-guided stereotactic radiosurgery alone. In another 8 patients who had prior endoscopic transsphenoidal radical excision, uptake was noted as residual lesion on PET-CT. Of them, 3 underwent subtotal excision and 5 had PET-CT-guided stereotactic radiosurgery. Biopsy was done in 14 patients, of which 11 were macroadenoma and 3 were microadenoma. Overall, magnetic resonance imaging (MRI) brain was performed in 22 of them and the findings were concordant with F18-FDG PET\/CT.<\/jats:p><jats:p>\n          Conclusion\u2003F18-FDG PET\/CT is a useful modality in the evaluation of pituitary uptake. It has an incremental value along with MRI brain and biochemical parameters and is useful for follow-up. Due to its high diagnostic accuracy, it is particularly useful in those with suspected residual\/recurrent adenomas.<\/jats:p>","DOI":"10.1055\/s-0044-1787967","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T23:11:07Z","timestamp":1719357067000},"page":"234-241","source":"Crossref","is-referenced-by-count":7,"title":["Utility of F18-FDG PET\/CT in the Evaluation of Pituitary Uptake"],"prefix":"10.1055","volume":"23","author":[{"given":"Adersh","family":"Stanly","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya Sara","family":"Sunny","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesarghatta Shyamasunde","family":"Asha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junita Rachel","family":"John","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hephzibah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0960-7404(97)00008-X","article-title":"Pituitary tumors: surgical and medical management","volume":"6","author":"P J Yeh","year":"1997","journal-title":"Surg Oncol"},{"key":"ref2","volume-title":"Pituitary Adenoma","author":"S Russ","year":"2023"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017","volume":"22","author":"Q T 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