{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:37:41Z","timestamp":1785800261878,"version":"3.56.0"},"reference-count":187,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inherited disorders of primary hemostasis, such as von Willebrand disease and congenital platelet disorders, can cause extensive, typically mucocutaneous bleeding. Assays to diagnose and monitor these disorders, such as von Willebrand factor activity assays and light transmission aggregometry, are performed in specialized hemostasis laboratories but are commonly not available in local hospitals. Due to the complexity and relative scarcity of these conventional assays, point-of-care tests (POCT) might be an attractive alternative in patients with hereditary bleeding disorders. POCTs, such as thromboelastography, are increasingly used to assess hemostasis in patients with acquired hemostatic defects, aiding clinical decision-making in critical situations, such as during surgery or childbirth. In comparison, the use of these assays in patients with hereditary hemostasis defects remains relatively unexplored. This review aims to give an overview of point-of-care hemostasis tests in patients with hereditary disorders of primary hemostasis. A summary of the literature reporting on the performance of currently available and experimental POCTs in these disorders is given, and the potential utility of the assays in various use scenarios is discussed. Altogether, the studies included in this review reveal that several POCTs are capable of identifying and monitoring severe defects in the primary hemostasis, while a POCT that can reliably detect milder defects of primary hemostasis is currently lacking. A better understanding of the strengths and limitations of POCTs in assessing hereditary defects of primary hemostasis is needed, after which these tests may become available for clinical practice, potentially targeting a large group of patients with milder defects of primary hemostasis.<\/jats:p>","DOI":"10.1055\/s-0044-1787976","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T23:15:57Z","timestamp":1719875757000},"page":"541-559","source":"Crossref","is-referenced-by-count":7,"title":["Point-of-Care Testing in Patients with Hereditary Disorders of Primary Hemostasis: A Narrative Review"],"prefix":"10.1055","volume":"51","author":[{"given":"Aernoud P.","family":"Bavinck","sequence":"additional","affiliation":[{"name":"Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waander van","family":"Heerde","sequence":"additional","affiliation":[{"name":"Department of Hematology, Radboud University Medical Centre, Hemophilia Treatment Centre Nijmegen-Eindhoven-Maastricht, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia E.M.","family":"Schols","sequence":"additional","affiliation":[{"name":"Department of Hematology, Radboud University Medical Centre, Hemophilia Treatment Centre Nijmegen-Eindhoven-Maastricht, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1538-7836.2009.03661.x","article-title":"The prevalence of symptomatic von Willebrand disease in primary care practice","volume":"8","author":"M Bowman","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/jth.15113","article-title":"Population based frequency of naturally occurring loss-of-function variants in genes associated with platelet disorders","volume":"19","author":"J H Oved","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/jth.12650","article-title":"Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey","volume":"12","author":"P Gresele","year":"2014","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.hrtlng.2005.07.004","article-title":"Overuse of prothrombin and partial thromboplastin coagulation tests in medical inpatients","volume":"34","author":"F H Pilsczek","year":"2005","journal-title":"Heart Lung"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3324\/haematol.2014.105924","article-title":"Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia","volume":"99","author":"P Noris","year":"2014","journal-title":"Haematologica"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/hae.14739","article-title":"Development of a target product profile (TTP) for haemophilia point-of-care (POC) diagnostic devices for low-resource countries and remote settings","volume":"29","author":"J Hagembe","year":"2023","journal-title":"Haemophilia"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tmrv.2020.09.012","article-title":"Systematic review and meta-analysis of diagnostic test accuracy studies evaluating point-of-care tests of coagulopathy in cardiac surgery","volume":"35","author":"M J Wo\u017aniak","year":"2021","journal-title":"Transfus Med Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bpa.2022.08.002","article-title":"Point-of-care coagulation testing for postpartum haemorrhage","volume":"36","author":"P Collins","year":"2022","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/a-1938-1984","article-title":"Global coagulation testing in acute care medicine: back to bedside?","volume":"42","author":"M Caspers","year":"2022","journal-title":"Hamostaseologie"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1515\/cclm-2016-0381","article-title":"Point-of-care testing INR: an overview","volume":"55","author":"D Barcellona","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"ref11","volume-title":"A History of Blood Coagulation","author":"C A Owen","year":"2001"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2007-1002658","article-title":"A critical reappraisal of the bleeding time","volume":"16","author":"R P Rodgers","year":"1990","journal-title":"Semin Thromb Hemost"},{"key":"ref13","first-page":"25","article-title":"The capillary thrombometer revisited","volume":"17","author":"R P Kadota","year":"1987","journal-title":"Haemostasis"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0049-3848(87)90191-5","article-title":"The capillary thrombometer and von Willebrand factor","volume":"45","author":"R P Kadota","year":"1987","journal-title":"Thromb Res"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0049-3848(83)90012-9","article-title":"Filter bleeding time: a new in vitro test of hemostasis. II. Application to the study of von Willebrand disease and platelet function inhibitors","volume":"31","author":"S Uchiyama","year":"1983","journal-title":"Thromb Res"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00001721-199603000-00012","article-title":"Studies of the platelet filter test (shear dependent platelet aggregation) in patients with uncommon haemorrhagic disorders","volume":"7","author":"Z Boda","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00043426-200306000-00009","article-title":"Comparison of PFA-100 and bleeding time testing in pediatric patients with suspected hemorrhagic problems","volume":"25","author":"R Cariappa","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"issue":"01","key":"ref18","first-page":"35","article-title":"Evaluation of the PFA-100 system in the diagnosis and therapeutic monitoring of patients with von Willebrand disease","volume":"82","author":"M Cattaneo","year":"1999","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s00277-011-1266-4","article-title":"von Willebrand disease: a clinical and laboratory study of sixty-five patients","volume":"90","author":"Y C Chen","year":"2011","journal-title":"Ann Hematol"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.thromres.2005.02.004","article-title":"Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency","volume":"116","author":"Y Dargaud","year":"2005","journal-title":"Thromb Res"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1055\/s-0037-1614035","article-title":"von Willebrand disease in a pediatric-based population\u2013comparison of type 1 diagnostic criteria and use of the PFA-100 and a von Willebrand factor\/collagen-binding assay","volume":"84","author":"J A Dean","year":"2000","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref22","first-page":"670","article-title":"Evaluation of the PFA-100 system for monitoring desmopressin therapy in patients with type 1 von Willebrand's disease","volume":"87","author":"M Franchini","year":"2002","journal-title":"Haematologica"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-2141.1999.01604.x","article-title":"Therapeutic monitoring of von Willebrand disease: interest and limits of a platelet function analyser at high shear rates","volume":"106","author":"E Fressinaud","year":"1999","journal-title":"Br J Haematol"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1182\/blood.V91.4.1325","article-title":"Screening for von Willebrand disease with a new analyzer using high shear stress: a study of 60 cases","volume":"91","author":"E Fressinaud","year":"1998","journal-title":"Blood"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/adc.86.4.297","article-title":"Hermansky-Pudlak syndrome: infrequent bleeding and first report of Turkish and Pakistani kindreds","volume":"86","author":"C Harrison","year":"2002","journal-title":"Arch Dis Child"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0049-3848(99)00152-8","article-title":"Comparison of PFA-100 closure time and template bleeding time of patients with inherited disorders causing defective platelet function","volume":"96","author":"A Ker\u00e9nyi","year":"1999","journal-title":"Thromb Res"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2007-995840","article-title":"PFA-100 system: a new method for assessment of platelet dysfunction","volume":"24","author":"E F Mammen","year":"1998","journal-title":"Semin Thromb Hemost"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1046\/j.1365-2516.2003.00755.x","article-title":"The role of the platelet function analyser (PFA-100) in the characterization of patients with von Willebrand's disease and its relationships with von Willebrand factor and the ABO blood group","volume":"9","author":"I C Nitu-Whalley","year":"2003","journal-title":"Haemophilia"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/ajh.20470","article-title":"von Willebrand disease R1374C: type 2A or 2M? A challenge to the revised classification. High frequency in the northwest of Spain (Galicia)","volume":"80","author":"N Penas","year":"2005","journal-title":"Am J Hematol"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2516.2005.01129.x","article-title":"Screening women with menorrhagia for underlying bleeding disorders: the utility of the platelet function analyser and bleeding time","volume":"11","author":"C S Philipp","year":"2005","journal-title":"Haemophilia"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1111\/j.1538-7836.2007.02752.x","article-title":"Usefulness of PFA-100 testing in the diagnostic screening of patients with suspected abnormalities of hemostasis: comparison with the bleeding time","volume":"5","author":"G M Podda","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1160\/TH03-01-0004","article-title":"Comparison of PFA-100 testing and bleeding time for detecting platelet hypofunction and von Willebrand disease in clinical practice","volume":"90","author":"E Posan","year":"2003","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref33","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1538-7836.2004.00693.x","article-title":"Template bleeding time and PFA-100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients","volume":"2","author":"T Quiroga","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1055\/s-2007-996051","article-title":"Use of the PFA-100 in the assessment of primary, platelet-related hemostasis in a pediatric setting","volume":"24","author":"M L Rand","year":"1998","journal-title":"Semin Thromb Hemost"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1055\/s-0037-1613973","article-title":"Comparison of the O'Brien filter test and the PFA-100 platelet analyzer in the laboratory diagnosis of von Willebrand's disease","volume":"84","author":"A Schlammadinger","year":"2000","journal-title":"Thromb Haemost"},{"key":"ref36","first-page":"443","article-title":"Evaluation of a platelet function analyser (PFA-100) in patients with a bleeding tendency","volume":"132","author":"W A Wuillemin","year":"2002","journal-title":"Swiss Med Wkly"},{"issue":"05","key":"ref37","doi-asserted-by":"crossref","first-page":"e748","DOI":"10.1097\/MPH.0000000000001925","article-title":"Comparison between bleeding time and PFA-200 to evaluate platelet function disorder in children","volume":"43","author":"C Srichumpuang","year":"2021","journal-title":"J Pediatr Hematol Oncol"},{"issue":"15","key":"ref38","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1039\/C7LC00498B","article-title":"Application of a strain rate gradient microfluidic device to von Willebrand's disease screening","volume":"17","author":"R J Brazilek","year":"2017","journal-title":"Lab Chip"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2257.1984.tb00552.x","article-title":"Platelet aggregometry on whole blood: the use of the ELT 8\/ds blood cell counter in the investigation of bleeding disorders","volume":"6","author":"J E Cheeseman","year":"1984","journal-title":"Clin Lab Haematol"},{"issue":"S 02","key":"ref40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1055\/s-0032-1313612","article-title":"Description of an in vitro platelet function analyzer\u2013PFA-100","volume":"21","author":"S K Kundu","year":"1995","journal-title":"Semin Thromb Hemost"},{"issue":"06","key":"ref41","first-page":"357","article-title":"Simulation of primary haemostasis in vitro","volume":"15","author":"M A Kratzer","year":"1985","journal-title":"Haemostasis"},{"issue":"05","key":"ref42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1515\/cclm-2022-0666","article-title":"Towards 50 years of platelet function analyser (PFA) testing","volume":"61","author":"E J Favaloro","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.thromres.2020.01.029","article-title":"Utility of the platelet function analyser (PFA-100\/200) for exclusion or detection of von Willebrand disease: a study 22 years in the making","volume":"188","author":"E J Favaloro","year":"2020","journal-title":"Thromb Res"},{"issue":"08","key":"ref44","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/09537100412331272587","article-title":"Abstracts from the 10th Erfurt Conference on Platelets. June 20-23, 2004. Erfurt, Germany","volume":"15","year":"2004","journal-title":"Platelets"},{"issue":"01","key":"ref45","first-page":"138P","article-title":"The 'electronic platelet aggregometer' [proceedings]","volume":"66","author":"D C Cardinal","year":"1979","journal-title":"Br J Pharmacol"},{"key":"ref46","first-page":"577","article-title":"[Blood clotting studies with thrombus stressography; a new investigation procedure]","volume":"26","author":"H Hartert","year":"1948","journal-title":"Klin Wochenschr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jss.2017.01.008","article-title":"Assessment of three point-of-care platelet function assays in adult trauma patients","volume":"212","author":"C R Connelly","year":"2017","journal-title":"J Surg Res"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/j.jvca.2014.06.025","article-title":"Preoperative point-of-care platelet function testing in cardiac surgery","volume":"29","author":"S Agarwal","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0049-3848(98)00163-7","article-title":"The xylum clot signature analyzer: a dynamic flow system that simulates vascular injury","volume":"92","author":"C K Li","year":"1998","journal-title":"Thromb Res"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00001721-199502000-00012","article-title":"A flow dynamic technique used to assess global haemostasis","volume":"6","author":"K M Muga","year":"1995","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"01","key":"ref51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00001721-199901000-00004","article-title":"Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis","volume":"10","author":"P Harrison","year":"1999","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"05","key":"ref52","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/hae.12653","article-title":"Platelet function analyser (PFA-100) results and von Willebrand factor deficiency: a 16-year 'real-world' experience","volume":"21","author":"L Ardillon","year":"2015","journal-title":"Haemophilia"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1365-2141.1998.00656.x","article-title":"The platelet function analyzer (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children","volume":"101","author":"M D Carcao","year":"1998","journal-title":"Br J Haematol"},{"issue":"06","key":"ref54","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1160\/TH15-09-0757","article-title":"Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia","volume":"115","author":"R Kumar","year":"2016","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref55","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MBC.0000000000000596","article-title":"Practice patterns in the diagnosis of inherited platelet disorders within a single institution","volume":"28","author":"J Perez Botero","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"03","key":"ref56","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1096-8652(199911)62:3<165::AID-AJH6>3.0.CO;2-C","article-title":"Use of a novel platelet function analyzer (PFA-100) with high sensitivity to disturbances in von Willebrand factor to screen for von Willebrand's disease and other disorders","volume":"62","author":"E J Favaloro","year":"1999","journal-title":"Am J Hematol"},{"issue":"04","key":"ref57","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00001721-200206000-00011","article-title":"Rational use of the PFA-100 device for screening of platelet function disorders and von Willebrand disease","volume":"13","author":"Y Buyukasik","year":"2002","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"07","key":"ref59","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/pbc.24456","article-title":"Utility of platelet function analyzer as a screening tool for the diagnosis of von Willebrand disease in adolescents with menorrhagia","volume":"60","author":"S Naik","year":"2013","journal-title":"Pediatr Blood Cancer"},{"issue":"04","key":"ref60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2257.2002.00451.x","article-title":"The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction","volume":"24","author":"P Harrison","year":"2002","journal-title":"Clin Lab Haematol"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/s-0037-1616120","article-title":"Reassessment of the correlation between the von Willebrand factor activity, the PFA-100, and the bleeding time in patients with von Willebrand disease","volume":"86","author":"I C Nitu-Whalley","year":"2001","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref62","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1538-7836.2006.01748.x","article-title":"Screening for bleeding disorders in women with menorrhagia using a platelet function analyzer","volume":"4","author":"A Veyradier","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref63","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/08880018.2014.886316","article-title":"The frequency of menorrhagia and bleeding disorders in university students","volume":"31","author":"T Gursel","year":"2014","journal-title":"Pediatr Hematol Oncol"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/ijlh.12785","article-title":"Comprehensive re-evaluation of historical von Willebrand disease diagnosis in association with whole blood platelet aggregation and function","volume":"40","author":"V Nummi","year":"2018","journal-title":"Int J Lab Hematol"},{"issue":"04","key":"ref65","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/09537104.2018.1475631","article-title":"Usefulness of multiple electrode aggregometry as a screening tool for bleeding disorders in a pediatric hospital","volume":"30","author":"T Haas","year":"2019","journal-title":"Platelets"},{"issue":"08","key":"ref66","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/09537104.2011.640967","article-title":"Evaluation of the new INNOVANCE\u00ae PFA P2Y cartridge in patients with impaired primary haemostasis","volume":"23","author":"J Koessler","year":"2012","journal-title":"Platelets"},{"issue":"04","key":"ref67","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1055\/s-0037-1614097","article-title":"von Willebrand factor ristocetin cofactor activity correlates with platelet function in a high shear stress system","volume":"84","author":"A Veyradier","year":"2000","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref68","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1111\/bjh.16925","article-title":"Evaluation of the potential utility of the total thrombus-formation analysis system in comparison to the platelet function analyser in subjects with primary haemostatic defects","volume":"191","author":"J Charpy","year":"2020","journal-title":"Br J Haematol"},{"issue":"12","key":"ref69","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1111\/j.1538-7836.2004.01024.x","article-title":"Template bleeding time and PFA-100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study of 148 patients\u2013a rebuttal","volume":"2","author":"E J Favaloro","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2141.2007.06850.x","article-title":"Differential identification of a rare form of platelet-type (pseudo-) von Willebrand disease (VWD) from type 2B VWD using a simplified ristocetin-induced-platelet-agglutination mixing assay and confirmed by genetic analysis","volume":"139","author":"E J Favaloro","year":"2007","journal-title":"Br J Haematol"},{"issue":"06","key":"ref71","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1160\/TH06-09-0495","article-title":"Comparison of the pharmacokinetics of two von Willebrand factor concentrates [Biostate and AHF (high purity)] in people with von Willebrand disorder. A randomised cross-over, multi-centre study","volume":"97","author":"E J Favaloro","year":"2007","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref72","doi-asserted-by":"crossref","first-page":"E21","DOI":"10.1177\/1076029610379847","article-title":"Resemblance to vWD types and laboratory diagnosis of obligatory carriers of type 3 von Willebrand disease","volume":"17","author":"M Akin","year":"2011","journal-title":"Clin Appl Thromb Hemost"},{"issue":"06","key":"ref73","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1751-553X.2007.00882.x","article-title":"Utility of the PFA-100 analyser in the evaluation of primary haemostasis in a paediatric population","volume":"29","author":"J M Perel","year":"2007","journal-title":"Int J Lab Hematol"},{"issue":"04","key":"ref74","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/MBC.0000000000001033","article-title":"Screening hemostatic defects in Saudi University students with unexplained menorrhagia: a diagnosis, which could be missed","volume":"32","author":"S Bakr","year":"2021","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4274\/Tjh.2011.0048","article-title":"Screening bleeding disorders in adolescents and young women with menorrhagia","volume":"30","author":"S Cak\u0131 K\u0131l\u0131\u00e7","year":"2013","journal-title":"Turk J Haematol"},{"issue":"08","key":"ref76","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/j.1538-7836.2011.04400.x","article-title":"Multiplate whole blood impedance aggregometry: a new tool for von Willebrand disease","volume":"9","author":"V Valarche","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref77","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4274\/tjh.2011.0020","article-title":"The prevalence of von Willebrand disease and significance of in vitro bleeding time (PFA-100) in von Willebrand disease screening in the \u0130zmir region","volume":"30","author":"F Sap","year":"2013","journal-title":"Turk J Haematol"},{"issue":"03","key":"ref78","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/ijlh.13787","article-title":"Laboratory characterization of obligate carriers of type 3 von Willebrand disease with a potential role for platelet function analyzer (PFA-200)","volume":"44","author":"T Geevar","year":"2022","journal-title":"Int J Lab Hematol"},{"issue":"08","key":"ref79","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1055\/s-0029-1145254","article-title":"Clinical utility of the PFA-100","volume":"34","author":"E J Favaloro","year":"2008","journal-title":"Semin Thromb Hemost"},{"issue":"02","key":"ref80","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1365-2516.2001.00487.x","article-title":"Laboratory diagnosis of von Willebrand disorder (vWD) and monitoring of DDAVP therapy: efficacy of the PFA-100 and vWF:CBA as combined diagnostic strategies","volume":"7","author":"E J Favaloro","year":"2001","journal-title":"Haemophilia"},{"issue":"05","key":"ref81","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/1076029610366440","article-title":"An evaluation of the DDAVP infusion test with PFA-100 and vWF activity assays to distinguish vWD types in children","volume":"17","author":"M Akin","year":"2011","journal-title":"Clin Appl Thromb Hemost"},{"issue":"04","key":"ref82","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09537100601100366","article-title":"Diagnostic performance of the platelet function analyzer (PFA-100) for the detection of disorders of primary haemostasis in patients with a bleeding history-a systematic review and meta-analysis","volume":"18","author":"R Karger","year":"2007","journal-title":"Platelets"},{"issue":"11","key":"ref83","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1182\/blood.V112.11.4560.4560","article-title":"Thromboelastogram platelet mapping accurately predicts bleeding phenotype in Glanzmann thrombasthenia","volume":"112","author":"M U Callaghan","year":"2008","journal-title":"Blood"},{"issue":"01","key":"ref84","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/09537104.2017.1371290","article-title":"Screening for platelet function disorders with multiplate and platelet function analyzer","volume":"30","author":"F CJI Moenen","year":"2019","journal-title":"Platelets"},{"issue":"03","key":"ref85","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/bjh.14623","article-title":"Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions","volume":"181","author":"S Al-Battat","year":"2018","journal-title":"Br J Haematol"},{"issue":"04","key":"ref86","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/ijlh.12320","article-title":"Diagnosis of Glanzmann thrombasthenia by whole blood impedance analyzer (MEA) vs. light transmission aggregometry","volume":"37","author":"A Albanyan","year":"2015","journal-title":"Int J Lab Hematol"},{"issue":"02","key":"ref87","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ajh.23891","article-title":"Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome\u2013a case control study","volume":"90","author":"G Bragadottir","year":"2015","journal-title":"Am J Hematol"},{"issue":"03","key":"ref88","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/01443610802141910","article-title":"The usefulness of the platelet function analyser (PFA-100) in screening for underlying bleeding disorders in women with menorrhagia","volume":"28","author":"S Acharya","year":"2008","journal-title":"J Obstet Gynaecol"},{"issue":"04","key":"ref89","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1365-2516.2011.02733.x","article-title":"The PFA-100 \u00ae does not predict delta-granule platelet storage pool deficiencies","volume":"18","author":"J L Sladky","year":"2012","journal-title":"Haemophilia"},{"issue":"02","key":"ref90","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.jpag.2010.11.004","article-title":"Recurrent menorrhagia in an adolescent with a platelet secretion defect","volume":"24","author":"X M Santos","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"03","key":"ref91","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1365-2141.2008.07468.x","article-title":"Clinical and laboratory phenotypes associated with the aspirin-like defect: a study in 17 unrelated families","volume":"144","author":"N Rolf","year":"2009","journal-title":"Br J Haematol"},{"issue":"S 01","key":"ref92","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.5482\/HAMO-14-02-0011","article-title":"Significance of platelet function diagnostics for clarification of suspected battered child syndrome","volume":"34","author":"R Kn\u00f6fler","year":"2014","journal-title":"Hamostaseologie"},{"issue":"06","key":"ref93","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1365-2141.2010.08304.x","article-title":"Bleeding disorders in Lowe syndrome patients: evidence for a link between OCRL mutations and primary haemostasis disorders","volume":"150","author":"D Lasne","year":"2010","journal-title":"Br J Haematol"},{"issue":"02","key":"ref94","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.thromres.2013.11.022","article-title":"Usefulness of the INNOVANCE PFA P2Y test cartridge for the detection of patients with congenital defects of the platelet P2Y12 receptor for adenosine diphosphate","volume":"133","author":"M Scavone","year":"2014","journal-title":"Thromb Res"},{"issue":"04","key":"ref95","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1055\/s-0040-1721502","article-title":"Utility of the platelet function analyzer in patients with suspected platelet function disorders: diagnostic accuracy study","volume":"4","author":"J Kaufmann","year":"2020","journal-title":"TH Open"},{"issue":"12","key":"ref96","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/pan.12723","article-title":"Ability of hemostatic assessment to detect bleeding disorders and to predict abnormal surgical blood loss in children: a systematic review and meta-analysis","volume":"25","author":"J Guay","year":"2015","journal-title":"Paediatr Anaesth"},{"issue":"01","key":"ref97","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1160\/TH06-09-0493","article-title":"PFA-100 closure times in preoperative screening in 500 pediatric patients","volume":"98","author":"B Roschitz","year":"2007","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref98","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/107602960401000206","article-title":"A practical concept for preoperative management of patients with impaired primary hemostasis","volume":"10","author":"J Koscielny","year":"2004","journal-title":"Clin Appl Thromb Hemost"},{"issue":"03","key":"ref99","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1160\/TH07-08-0527","article-title":"PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII\/VWF concentrate substitution in von Willebrand disease type 1 and 2","volume":"100","author":"H H van Vliet","year":"2008","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref100","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1365-2516.2008.01672.x","article-title":"Evaluation of desmopressin effects on haemostasis in children with congenital bleeding disorders","volume":"14","author":"F L Hanebutt","year":"2008","journal-title":"Haemophilia"},{"issue":"02","key":"ref101","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1179\/1607845412Y.0000000051","article-title":"Response to low-dose desmopressin by a subcutaneous route in children with type 1 von Willebrand disease","volume":"18","author":"M Akin","year":"2013","journal-title":"Hematology"},{"issue":"06","key":"ref102","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/MBC.0b013e32832da1ad","article-title":"Potential supplementary utility of combined PFA-100 and functional von Willebrand factor testing for the laboratory assessment of desmopressin and factor concentrate therapy in von Willebrand disease","volume":"20","author":"E J Favaloro","year":"2009","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"09","key":"ref103","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002770050542","article-title":"The platelet function analyzer (PFA-100) may not be suitable for monitoring the therapeutic efficiency of von Willebrand concentrate in type III von Willebrand disease","volume":"78","author":"A Meskal","year":"1999","journal-title":"Ann Hematol"},{"issue":"02","key":"ref104","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/09537104.2017.1420153","article-title":"Sensitive and specific assessment of recombinant von Willebrand factor in platelet function analyzer","volume":"30","author":"I Pekrul","year":"2019","journal-title":"Platelets"},{"issue":"02","key":"ref105","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1111\/hae.13916","article-title":"Assessment of primary haemostasis with a new recombinant von Willebrand factor in patients with von Willebrand disease","volume":"26","author":"M Trossa\u00ebrt","year":"2020","journal-title":"Haemophilia"},{"issue":"03","key":"ref106","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2141.2010.08333.x","article-title":"The impact of bleeding history, von Willebrand factor and PFA-100(\u00ae) on the diagnosis of type 1 von Willebrand disease: results from the European study MCMDM-1VWD","volume":"151","author":"G Castaman","year":"2010","journal-title":"Br J Haematol"},{"issue":"01","key":"ref107","first-page":"93","article-title":"Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center","volume":"84","author":"T L Ortel","year":"2000","journal-title":"Thromb Haemost"},{"issue":"05","key":"ref108","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2257.2004.00632.x","article-title":"Evaluation of primary haemostasis in people with neurofibromatosis type 1","volume":"26","author":"E J Favaloro","year":"2004","journal-title":"Clin Lab Haematol"},{"issue":"07","key":"ref109","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1080\/09537104.2016.1257784","article-title":"Evaluating platelet function disorders in children with bleeding tendency - a single center study","volume":"28","author":"O Tanous","year":"2017","journal-title":"Platelets"},{"issue":"01","key":"ref110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1365-2516.2008.01893.x","article-title":"PFA-100 testing for pretherapeutic assessment of response to DDAVP in patients with von Willebrand's disease","volume":"15","author":"H Weston","year":"2009","journal-title":"Haemophilia"},{"issue":"06","key":"ref111","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/bjh.18003","article-title":"Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time","volume":"196","author":"F CJI Heubel-Moenen","year":"2022","journal-title":"Br J Haematol"},{"issue":"02","key":"ref112","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1538-7836.2006.01771.x","article-title":"Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function","volume":"4","author":"C P Hayward","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref113","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/ajh.24620","article-title":"Clinical utility of closure times using the platelet function analyzer-100\/200","volume":"92","author":"E J Favaloro","year":"2017","journal-title":"Am J Hematol"},{"issue":"01","key":"ref114","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/hae.12610","article-title":"Comprehensive evaluation of haemostatic function in von Willebrand disease patients using a microchip-based flow chamber system","volume":"21","author":"K Ogiwara","year":"2015","journal-title":"Haemophilia"},{"issue":"06","key":"ref115","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/hae.12971","article-title":"Usefulness of the total thrombus-formation analysis system (T-TAS) in the diagnosis and characterization of von Willebrand disease","volume":"22","author":"V Daidone","year":"2016","journal-title":"Haemophilia"},{"issue":"02","key":"ref116","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/ped.14378","article-title":"A microchip flow-chamber assay screens congenital primary hemostasis disorders","volume":"63","author":"Y Nakajima","year":"2021","journal-title":"Pediatr Int"},{"issue":"04","key":"ref117","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jth.13273","article-title":"Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system","volume":"14","author":"K Nogami","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref118","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12185-019-02782-z","article-title":"Evaluation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system","volume":"111","author":"Y Nakajima","year":"2020","journal-title":"Int J Hematol"},{"issue":"01","key":"ref119","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1160\/TH16-06-0430","article-title":"Monitoring of coagulation factor therapy in patients with von Willebrand disease type 3 using a microchip flow chamber system","volume":"117","author":"A \u00c5gren","year":"2017","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12185-015-1819-8","article-title":"Use of a microchip flow-chamber system as a screening test for platelet storage pool disease","volume":"102","author":"H Minami","year":"2015","journal-title":"Int J Hematol"},{"issue":"07","key":"ref122","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/09537104.2018.1535704","article-title":"Evaluation of the total thrombus-formation system (T-TAS): application to human and mouse blood analysis","volume":"30","author":"R Al Ghaithi","year":"2019","journal-title":"Platelets"},{"issue":"03","key":"ref123","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1111\/hae.13725","article-title":"Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease","volume":"25","author":"Y Nakajima","year":"2019","journal-title":"Haemophilia"},{"issue":"08","key":"ref124","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1160\/TH17-02-0129","article-title":"Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease","volume":"117","author":"D E Schmidt","year":"2017","journal-title":"Thromb Haemost"},{"issue":"05","key":"ref125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/09537100903006246","article-title":"Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia","volume":"20","author":"A Awidi","year":"2009","journal-title":"Platelets"},{"issue":"12","key":"ref126","doi-asserted-by":"crossref","first-page":"e52878","DOI":"10.1371\/journal.pone.0052878","article-title":"Abnormal whole blood thrombi in humans with inherited platelet receptor defects","volume":"7","author":"F J Castellino","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"ref127","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/jth.13784","article-title":"Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders","volume":"15","author":"R Al Ghaithi","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref128","doi-asserted-by":"crossref","first-page":"a006110","DOI":"10.1101\/mcs.a006110","article-title":"A novel likely pathogenic variant in a patient with Hermansky-Pudlak syndrome","volume":"7","author":"L A Lansdon","year":"2021","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"02","key":"ref129","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11739-008-0105-7","article-title":"Platelet dysfunction and other hemostatic disorders in women with menorrhagia: the utility of whole blood lumi-aggregometer","volume":"3","author":"O M Akay","year":"2008","journal-title":"Intern Emerg Med"},{"issue":"02","key":"ref130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/hae.12293","article-title":"Platelet function defects in adolescents with heavy menstrual bleeding","volume":"20","author":"H L Mills","year":"2014","journal-title":"Haemophilia"},{"issue":"05","key":"ref131","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1532\/IJH97.06214","article-title":"Factor VIII-mediated global hemostasis in the absence of von Willebrand factor","volume":"85","author":"M Takeyama","year":"2007","journal-title":"Int J Hematol"},{"issue":"02","key":"ref132","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/hae.13121","article-title":"A prospective diagnostic accuracy study evaluating rotational thromboelastometry and thromboelastography in 100 patients with von Willebrand disease","volume":"23","author":"D E Schmidt","year":"2017","journal-title":"Haemophilia"},{"issue":"07","key":"ref133","doi-asserted-by":"crossref","first-page":"e27714","DOI":"10.1002\/pbc.27714","article-title":"Utility of thromboelastography for the diagnosis of von Willebrand disease","volume":"66","author":"K Regling","year":"2019","journal-title":"Pediatr Blood Cancer"},{"issue":"01","key":"ref134","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/09537104.2019.1581922","article-title":"Platelets compensate for poor thrombin generation in type 3 von Willebrand disease","volume":"31","author":"T Szanto","year":"2020","journal-title":"Platelets"},{"issue":"06","key":"ref135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/EJA.0000000000000985","article-title":"Thromboelastometry as a diagnostic tool in mild bleeding disorders: a prospective cohort study","volume":"36","author":"A Wieland Greguare-Sander","year":"2019","journal-title":"Eur J Anaesthesiol"},{"issue":"04","key":"ref136","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0888-6296(87)80046-7","article-title":"Use of thromboelastography in the management of von Willebrand's disease during cardiopulmonary bypass","volume":"1","author":"K J Tuman","year":"1987","journal-title":"J Cardiothorac Anesth"},{"issue":"04","key":"ref137","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5152\/TJAR.2014.69077","article-title":"Anaesthetic management with thromboelastography in a patient with Glanzmann thrombasthenia","volume":"42","author":"A Topal","year":"2014","journal-title":"Turk J Anaesthesiol Reanim"},{"issue":"04","key":"ref138","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4103\/0971-9784.216245","article-title":"Perioperative management of a patient with Glanzmann's thrombasthenia for mitral valve repair under cardiopulmonary bypass","volume":"20","author":"P P Simha","year":"2017","journal-title":"Ann Card Anaesth"},{"issue":"05","key":"ref139","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/00000542-199605000-00027","article-title":"Heparinase and thromboelastography in liver transplantation for a patient with von Willebrand's disease","volume":"84","author":"E G Pivalizza","year":"1996","journal-title":"Anesthesiology"},{"issue":"05","key":"ref140","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0952-8180(03)00022-9","article-title":"Perioperative use of the thrombelastograph in patients with inherited bleeding disorders","volume":"15","author":"E G Pivalizza","year":"2003","journal-title":"J Clin Anesth"},{"issue":"05","key":"ref141","doi-asserted-by":"crossref","first-page":"636","DOI":"10.6002\/ect.2019.0347","article-title":"Use of thromboelastography to guide platelet infusion in a patient with Wiskott-Aldrich syndrome undergoing renal transplant","volume":"18","author":"A Al Midani","year":"2020","journal-title":"Exp Clin Transplant"},{"issue":"04","key":"ref142","first-page":"247","article-title":"Major surgery (radical cystectomy with urethrectomy) in a patient with von Willebrand's disease type I. Reliability and limits of hemocoagulative tests","volume":"50","author":"M Favro","year":"1998","journal-title":"Minerva Urol Nefrol"},{"issue":"01","key":"ref143","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/MBC.0000000000000532","article-title":"Perioperative ROTEM and ROTEMplatelet monitoring in a case of Glanzmann's thrombasthenia","volume":"28","author":"A Grassetto","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"02","key":"ref144","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jclinane.2011.10.004","article-title":"Thrombelastography for perioperative monitoring in patients with von Willebrand disease","volume":"24","author":"S Guzman-Reyes","year":"2012","journal-title":"J Clin Anesth"},{"issue":"07","key":"ref145","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jclinane.2010.12.019","article-title":"Thrombelastograph platelet mapping in a patient with von Willebrand disease who was treated with Humate-P","volume":"23","author":"E Z Boyd","year":"2011","journal-title":"J Clin Anesth"},{"issue":"04","key":"ref146","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijoa.2011.04.006","article-title":"The use of thromboelastography for the peripartum management of a patient with platelet storage pool disorder","volume":"20","author":"J Campbell","year":"2011","journal-title":"Int J Obstet Anesth"},{"issue":"03","key":"ref147","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0267659110395648","article-title":"Expanding perfusion across disciplines: the use of thrombelastography technology to reduce risk in an obstetrics patient with gray platelet syndrome\u2013a case study","volume":"26","author":"A Clements","year":"2011","journal-title":"Perfusion"},{"issue":"02","key":"ref148","doi-asserted-by":"crossref","first-page":"e01658","DOI":"10.1213\/XAA.0000000000001658","article-title":"A case report of rotational thromboelastometry-assisted decision analysis for two pregnant patients with platelet storage pool disorder","volume":"17","author":"J Hale","year":"2023","journal-title":"A A Pract"},{"issue":"05","key":"ref149","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/bja\/88.5.734","article-title":"Peripartum management of a patient with Glanzmann's thrombasthenia using thrombelastograph","volume":"88","author":"S Monte","year":"2002","journal-title":"Br J Anaesth"},{"issue":"05","key":"ref150","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/09537104.2013.819971","article-title":"Complementary effect of fibrinogen and rFVIIa on clotting ex vivo in Bernard-Soulier syndrome and combined use during three deliveries","volume":"25","author":"R Palsson","year":"2014","journal-title":"Platelets"},{"issue":"02","key":"ref151","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijoa.2010.09.014","article-title":"The use of thromboelastography for the peripartum management of a patient with platelet storage pool disorder","volume":"20","author":"G Rajpal","year":"2011","journal-title":"Int J Obstet Anesth"},{"issue":"02","key":"ref152","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/1753495X20980254","article-title":"Platelet storage pool disorder in pregnancy: utilising thromboelastography to guide a risk-based delivery plan","volume":"15","author":"T A Snow","year":"2022","journal-title":"Obstet Med"},{"issue":"01","key":"ref153","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/hae.12481","article-title":"Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype","volume":"21","author":"A N Zia","year":"2015","journal-title":"Haemophilia"},{"issue":"08","key":"ref154","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3109\/09537104.2011.642031","article-title":"The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia","volume":"23","author":"B Shenkman","year":"2012","journal-title":"Platelets"},{"issue":"04","key":"ref155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pathophys.2018.05.005","article-title":"Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry","volume":"25","author":"I Budnik","year":"2018","journal-title":"Pathophysiology"},{"issue":"01","key":"ref156","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MBC.0000000000000870","article-title":"Clinico-hematological and thromboelastographic profiles in Glanzmann's thrombasthenia","volume":"31","author":"J Ahammad","year":"2020","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref157","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bcmd.2018.07.003","article-title":"A novel approach using ancillary tests to guide treatment of Glanzmann thrombasthenia patients undergoing surgical procedures","volume":"72","author":"A A Barg","year":"2018","journal-title":"Blood Cells Mol Dis"},{"issue":"02","key":"ref158","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1423-0410.2006.00797.x","article-title":"Monitoring survival and function of transfused platelets in Glanzmann thrombasthenia by flow cytometry and thrombelastography","volume":"91","author":"C Male","year":"2006","journal-title":"Vox Sang"},{"issue":"01","key":"ref159","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2516.2007.01592.x","article-title":"Evaluation of rFVIIa (NovoSeven) in Glanzmann patients with thromboelastogram","volume":"14","author":"M Lak","year":"2008","journal-title":"Haemophilia"},{"issue":"01","key":"ref160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0049-3848(01)00340-1","article-title":"Evaluation of the xylum clot signature analyzer in normal subjects and patients with the Hermansky-Pudlak syndrome","volume":"104","author":"M K Horne III","year":"2001","journal-title":"Thromb Res"},{"issue":"05","key":"ref161","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1538-7836.2004.00695.x","article-title":"A multicenter clinical evaluation of the clot signature analyzer","volume":"2","author":"W Fricke","year":"2004","journal-title":"J Thromb Haemost"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1016\/S0002-8703(98)70248-0","article-title":"Cone and plate(let) analyzer: monitoring glycoprotein IIb\/IIIa antagonists and von Willebrand disease replacement therapy by testing platelet deposition under flow conditions","volume":"135","author":"D Varon","year":"1998","journal-title":"Am Heart J"},{"issue":"04","key":"ref163","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0049-3848(00)00255-3","article-title":"Testing of platelet deposition on polystyrene surface under flow conditions by the cone and plate(let) analyzer: role of platelet activation, fibrinogen and von Willebrand factor","volume":"99","author":"B Shenkman","year":"2000","journal-title":"Thromb Res"},{"issue":"12","key":"ref164","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1538-7836.2009.03628.x","article-title":"Evaluation of children with a suspected bleeding disorder applying the Impact-R [Cone and Plate(let) analyzer]","volume":"7","author":"S Revel-Vilk","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref165","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/09537100802082256","article-title":"Testing agonist-induced platelet aggregation by the Impact-R [Cone and plate(let) analyzer (CPA)]","volume":"19","author":"B Shenkman","year":"2008","journal-title":"Platelets"},{"issue":"01","key":"ref166","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/jth.13881","article-title":"Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels","volume":"16","author":"M Lehmann","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref167","doi-asserted-by":"crossref","first-page":"e54680","DOI":"10.1371\/journal.pone.0054680","article-title":"Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays","volume":"8","author":"K B Neeves","year":"2013","journal-title":"PLoS One"},{"issue":"04","key":"ref168","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.thromres.2011.12.016","article-title":"Assessment of a cohort of primarily pediatric patients with a presumptive diagnosis of type 1 von Willebrand disease with a novel high shear rate, non-citrated blood flow device","volume":"129","author":"E F Grabowski","year":"2012","journal-title":"Thromb Res"},{"issue":"05","key":"ref169","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1055\/s-0040-1709525","article-title":"Differentiation of patients with symptomatic low von Willebrand factor from those with asymptomatic low von Willebrand factor","volume":"120","author":"E F Grabowski","year":"2020","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref170","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1038\/s41467-019-10067-6","article-title":"Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear","volume":"10","author":"Z Chen","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"ref171","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1111\/j.1538-7836.2006.02177.x","article-title":"Flow-based assays for global assessment of hemostasis. Part 1: biorheologic considerations","volume":"4","author":"J J Zwaginga","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref172","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1055\/s-0035-1556586","article-title":"Homeostasis of hemostasis: the role of endothelium","volume":"41","author":"R S Kazmi","year":"2015","journal-title":"Semin Thromb Hemost"},{"issue":"19","key":"ref173","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1073\/pnas.0608422104","article-title":"Shear-induced unfolding triggers adhesion of von Willebrand factor fibers","volume":"104","author":"S W Schneider","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"ref174","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1182\/bloodadvances.2022007550","article-title":"Traumatic vessel injuries initiating hemostasis generate high shear conditions","volume":"6","author":"A A Yakusheva","year":"2022","journal-title":"Blood Adv"},{"issue":"01","key":"ref175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09537100802364076","article-title":"The effect of ex vivo anticoagulants on whole blood platelet aggregation","volume":"20","author":"M L Kalb","year":"2009","journal-title":"Platelets"},{"issue":"11","key":"ref176","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1111\/j.1538-7836.2009.03589.x","article-title":"Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods","volume":"7","author":"N J Truss","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref177","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/09537104.2017.1327655","article-title":"Effects of pH and concentration of sodium citrate anticoagulant on platelet aggregation measured by light transmission aggregometry induced by adenosine diphosphate","volume":"29","author":"K Germanovich","year":"2018","journal-title":"Platelets"},{"issue":"09","key":"ref178","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1161\/01.CIR.96.9.2877","article-title":"Differential effects of anticoagulants on the activation of platelets ex vivo","volume":"96","author":"D J Schneider","year":"1997","journal-title":"Circulation"},{"issue":"03","key":"ref179","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1055\/s-0038-1651037","article-title":"Effect of the concentration of Ca2+ in the suspending medium on the responses of human and rabbit platelets to aggregating agents","volume":"62","author":"M A Packham","year":"1989","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2141.2010.08499.x","article-title":"Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation","volume":"153","author":"S Jones","year":"2011","journal-title":"Br J Haematol"},{"issue":"03","key":"ref181","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1515\/CCLM.2011.074","article-title":"Platelet function testing in hirudin and BAPA anticoagulated blood","volume":"49","author":"H Mani","year":"2011","journal-title":"Clin Chem Lab Med"},{"issue":"03","key":"ref182","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/09537104.2017.1384540","article-title":"Time dependent reduction in platelet aggregation using the multiplate analyser and hirudin blood due to platelet clumping","volume":"29","author":"K Chapman","year":"2018","journal-title":"Platelets"},{"issue":"10","key":"ref183","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/j.1538-7836.2007.02716.x","article-title":"Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin","volume":"5","author":"P Hellstern","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref184","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"P D James","year":"2021","journal-title":"Blood Adv"},{"issue":"04","key":"ref185","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/molecules25040833","article-title":"Microfluidics in haemostasis: a review","volume":"25","author":"H Jigar Panchal","year":"2020","journal-title":"Molecules"},{"key":"ref186","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fbioe.2019.00395","article-title":"Technology advancements in blood coagulation measurements for point-of-care diagnostic testing","volume":"7","author":"M Mohammadi Aria","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"issue":"23","key":"ref187","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1039\/D1LC00708D","article-title":"Fully automated light transmission aggregometry on a disc for platelet function tests","volume":"21","author":"C J Kim","year":"2021","journal-title":"Lab Chip"},{"issue":"01","key":"ref188","doi-asserted-by":"crossref","first-page":"2185453","DOI":"10.1080\/09537104.2023.2185453","article-title":"Hemostasis-on-a-chip \/ incorporating the endothelium in microfluidic models of bleeding","volume":"34","author":"Y Sakurai","year":"2023","journal-title":"Platelets"},{"issue":"06","key":"ref189","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1160\/TH07-05-0350","article-title":"Heterozygous loss of platelet glycoprotein (GP) Ib-V-IX variably affects platelet function in velocardiofacial syndrome (VCFS) patients","volume":"98","author":"H P Liang","year":"2007","journal-title":"Thromb Haemost"}],"container-title":["Seminars in Thrombosis and Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1787976.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:51:56Z","timestamp":1750204316000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1787976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":187,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,6,13]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1787976","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0094-6176","1098-9064"],"issn-type":[{"value":"0094-6176","type":"print"},{"value":"1098-9064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}