{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:09:40Z","timestamp":1791378580356,"version":"4.3.2"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between 2010 and 2016, elective oocyte cryopreservation (OC) increased in use by 880% in the United States; however, there have been increasing reports of regret among patients after elective OC. There is a growing need for individualized counseling on the timing and number of oocytes to cryopreserve for patients to make informed choices and set realistic expectations, but currently available tools seem to be insufficient. The purpose of this review is to describe the OC calculators currently available online, identify sources of regret, and illustrate the need for unified counseling tools for improved patient care and education. OC calculators were identified via Google search. Only calculators that cite scientific literature were included in the review. Calculators for in vitro fertilization or embryo transfer were excluded. Thirteen OC calculators were found; however, only six cited literature supporting the calculator's design. When entering the same hypothetical patient parameters for age and number of oocytes cryopreserved, the calculators provided drastically different probabilities of live births. The lack of cohesive online educational materials creates confusion and stress for patients considering OC, leading to unrealistic expectations and increased feelings of regret thereafter. Physicians need tools to provide comprehensive guidance to patients seeking to cryopreserve oocytes.<\/jats:p>","DOI":"10.1055\/s-0044-1788030","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T22:59:04Z","timestamp":1720652344000},"page":"130-139","source":"Crossref","is-referenced-by-count":2,"title":["Understanding the Strengths and Limitations of Online Oocyte Cryopreservation Calculators"],"prefix":"10.1055","volume":"42","author":[{"given":"Amber T.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Minis","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Mahalingaiah","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(86)90989-X","article-title":"Pregnancy after human oocyte cryopreservation","volume":"1","author":"C Chen","year":"1986","journal-title":"Lancet"},{"issue":"02","key":"ref2","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"L Rienzi","year":"2017","journal-title":"Hum Reprod Update"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/humrep\/deq146","article-title":"Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial","volume":"25","author":"A Cobo","year":"2010","journal-title":"Hum Reprod"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s10815-017-1017-0","article-title":"Egg donation of vitrified oocytes bank produces similar pregnancy rates by blastocyst transfer when compared to fresh cycle","volume":"34","author":"T S Domingues","year":"2017","journal-title":"J Assist Reprod Genet"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/humrep\/der008","article-title":"Efficacy of oocyte vitrification combined with blastocyst stage transfer in an egg donation program","volume":"26","author":"J I Garc\u00eda","year":"2011","journal-title":"Hum Reprod"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fertnstert.2012.09.028","article-title":"Mature oocyte cryopreservation: a guideline","volume":"99","author":"Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology","year":"2013","journal-title":"Fertil Steril"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/humrep\/deaa320","article-title":"A major increase in oocyte cryopreservation cycles in the USA, Australia and New Zealand since 2010 is highlighted by younger women but a need for standardized data collection","volume":"36","author":"M Johnston","year":"2021","journal-title":"Hum Reprod"},{"issue":"02","key":"ref8","first-page":"145","article-title":"Impact of the COVID-19 pandemic on the perception of planned oocyte cryopreservation in the United States","volume":"3","author":"A Huttler","year":"2022","journal-title":"F S Rep"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.fertnstert.2015.03.002","article-title":"Optimal timing for elective egg freezing","volume":"103","author":"T B Mesen","year":"2015","journal-title":"Fertil Steril"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12958-021-00884-0","article-title":"Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation","volume":"20","author":"Z Walker","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/aogs.13763","article-title":"Perceptions, outcomes, and regret following social egg freezing in the UK; 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