{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:06:15Z","timestamp":1780499175779,"version":"3.54.1"},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim\u2003High-dose epidermal radionuclide therapy using a nonsealed 188Re (Rhenium) resin is an alternative treatment option for nonmelanoma skin cancer. In this case study, we present the possible use of this therapy in a patient with multiple actinic keratosis (AK), which is a precancer of the skin.<\/jats:p><jats:p>\n          Methods\u2003A 55-year-old male was presented in our department with multiple AK, located on the cheek, temporal, and frontal area, with 1, 1, 2.1, and 2.5\u2009cm2 surface.<\/jats:p><jats:p>Applied activity was 80, 80, 167, and 168 MBq 188Re with a target absorbed dose for each lesion 35 Gy at 1\u2009mm. The treatment was well tolerated.<\/jats:p><jats:p>\n          Results\u2003At 17 months\u2019 follow-up, all treated area showed complete remission. There were no side effects, except mild focal hypopigmentation.<\/jats:p><jats:p>\n          Conclusion\u2003This case demonstrates the high potential of epidermal radionuclide therapy with a nonsealed 188Re as a noninvasive, effective, and well-tolerated therapy option for patients with multiple AK, when surgery is difficult to perform or not recommended of other reasons.<\/jats:p>","DOI":"10.1055\/s-0044-1788075","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T23:05:31Z","timestamp":1720134331000},"page":"285-287","source":"Crossref","is-referenced-by-count":5,"title":["High-Dose Epidermal Radionuclide Therapy with 188Re (Rhenium) Resin in a Patient with Multiple Actinic Keratoses"],"prefix":"10.1055","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-6811","authenticated-orcid":false,"given":"Siroos","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine with PET-Centre, Clinic Ottakring, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Kunstfeld","sequence":"additional","affiliation":[{"name":"University Department for Dermatology, Medical University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref1","volume-title":"Actinic Keratosis","author":"M Eric"},{"key":"ref2","volume-title":"Squamous Cell Skin Cancer. StatPearls [Internet]","author":"J Y Howell","year":"2023"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1365-2230.2008.02852.x","article-title":"Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma","volume":"33","author":"A F Sedda","year":"2008","journal-title":"Clin Exp Dermatol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1684\/ejd.2013.1927","article-title":"Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: a new therapy","volume":"23","author":"A M Carrozzo","year":"2013","journal-title":"Eur J Dermatol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00259-020-05088-z","article-title":"High dose brachytherapy with non sealed 188Re (rhenium) resin in patients with non-melanoma skin cancers (NMSCs): single center preliminary results","volume":"48","author":"P Castellucci","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.brachy.2015.06.005","article-title":"Aspects of dosimetry and clinical practice of skin brachytherapy: the American Brachytherapy Society working group report","volume":"14","author":"Z Ouhib","year":"2015","journal-title":"Brachytherapy"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1788075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:33:11Z","timestamp":1734046391000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1788075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":6,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,12,12]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1788075","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}