{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:16Z","timestamp":1787004916518,"version":"build-2736575974"},"reference-count":48,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thymomas are uncommon tumors that originate from epithelial cells of thymus and may have varying clinical course.<\/jats:p>\n                  <jats:p>A retrospective review of medical records of thymoma patients treated between January 2012 and April 2022 at our institute was conducted.<\/jats:p>\n                  <jats:p>There were a total of 23 patients (12 males and 11 females) with median age of 52 years (range, 33\u201377 years). Eleven patients (47.8%) had associated paraneoplastic syndromes of which 10 (43.5%) had myasthenia gravis and 1 (4.3%) had pure red cell aplasia. Average maximal tumor diameter was 62\u2009mm (28\u2013160\u2009mm). Masaoka-Koga stage distribution was as follows: stage I (n\u2009=\u20092, 8.7%), IIA (n\u2009=\u20094, 17.4%), IIB (n\u2009=\u20091, 4.3%), IIIA (n\u2009=\u20092, 8.7%), IIIB (n\u2009=\u20094, 17.4%), IVA (n\u2009=\u20097, 30.4%), and IVB (n\u2009=\u20093, 13.1%). The World Health Organization type B2 was the commonest histology (n\u2009=\u200912, 52.17%), followed by B3 (n =7, 30.4%), B1 (n\u2009=\u20092, 8.7%), AB (n\u2009=\u20091,4.3%), and A (n\u2009=\u20091, 4.3%). Six patients received neoadjuvant chemotherapy with cyclophosphamide regimen, 22 (95.6%) underwent surgery, and 1 patient received adjuvant chemotherapy. R0 resection was attained in 20 (91%) patients, R1 resection in 1 (4.5%) patient, and R2 in 1 (4.5%) patient. All operated patients underwent postoperative radiotherapy (45\u201360 Gy in 25\u201330 fractions). Four patients relapsed at a median duration of 14 months (2\u201326 months). At a median follow-up of 6 years, 5-year overall survival was 67.1% and 5-year progression-free survival was 66.6%. Local control at 5 years was 86.6%.<\/jats:p>\n                  <jats:p>Despite majority of our patients presenting at an advanced stage, the local control rates are encouraging and reinforce multimodality approach.<\/jats:p>","DOI":"10.1055\/s-0044-1788257","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T19:02:45Z","timestamp":1720465365000},"page":"324-332","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Outcomes of Thymoma Treated at a Single Institute"],"prefix":"10.25259","volume":"14","author":[{"given":"Sorun","family":"Shishak","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejinder","family":"Kataria","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam Singh","family":"Bisht","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-9464","authenticated-orcid":false,"given":"Susovan","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Kaliyaperumal","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal","family":"Narang","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Mayank","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Medanta The Medicity, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jtho.2021.10.010","article-title":"The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?","volume":"17","author":"A Marx","year":"2022","journal-title":"J Thorac Oncol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5306\/wjco.v12.i4.195","article-title":"GOECP\/SEOR radiotherapy guidelines for thymic epithelial tumours","volume":"12","author":"M Rico","year":"2021","journal-title":"World J Clin Oncol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.thorsurg.2018.12.001","article-title":"The role of the thymus in immune response","volume":"29","author":"P Thapa","year":"2019","journal-title":"Thorac Surg Clin"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.21037\/jtd-2019-thym-02","article-title":"Epidemiology of thymoma","volume":"12","author":"A L Rich","year":"2020","journal-title":"J Thorac Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S260","DOI":"10.1097\/JTO.0b013e3181f1f62d","article-title":"Epidemiology of thymoma and associated malignancies","volume":"5","author":"E A Engels","year":"2010","journal-title":"J Thorac Oncol"},{"key":"ref6","first-page":"2","article-title":"The pathology of the thymus in myasthenia gravis","volume":"\u2022\u2022\u2022","author":"A Marx","year":"2018","journal-title":"Mediastinum"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/paor.1999.0170","article-title":"Pericardial involvement by thymomas. 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