{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:15:30Z","timestamp":1751555730129,"version":"3.37.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to determine whether administration of a late preterm (34\u201336 weeks) course of antenatal corticosteroids (ACS) is associated with improved short-term neonatal outcomes among pregnancies complicated with hypertensive disorders of pregnancy (HDP) who delivered in the late preterm period.<\/jats:p><jats:p>\n            Study Design\u2003A single tertiary center retrospective cohort study, including pregnant individuals with singleton fetuses who delivered between 34.0 and 36.6 weeks following an HDP diagnosis. Exclusion criteria were major fetal anomalies and treatment with ACS before 34 weeks. Cases were divided into two groups: exposed group, consisting of individuals treated with a late ACS course, and nonexposed group, receiving no ACS. The primary outcome was a composite adverse neonatal outcome, including intensive care unit admission, oxygen treatment, noninvasive positive pressure ventilation, mechanical ventilation, respiratory distress syndrome, transient tachypnea, or apnea of prematurity. Secondary neonatal outcomes included birth weight, Apgar score, intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, surfactant use, hypoglycemia, hyperbilirubinemia, sepsis, and neonatal death. Multivariable regression models were used to determine adjusted odds ratio (aOR)and 95% confidence intervals (CIs).<\/jats:p><jats:p>\n            Results Of 7,624 preterm singleton deliveries during the study period, 438 (5.7%) were diagnosed with HDP and delivered between 34.0 and 36.6 weeks. Infants who received ACS were diagnosed more commonly with fetal growth restriction (16.0 vs. 5.6%, p\u2009&lt;\u20090.01) and were delivered at an earlier gestational age (GA) (mean GA: 35.6 vs. 36.3 weeks, p\u2009&lt;\u20090.01). The composite neonatal morbidity did not differ between the groups after adjustments (aOR: 0.97, 95% CI: 0.47, 1.98). Neonatal hypoglycemia and hyperbilirubinemia were more common in the exposed group than in the nonexposed group (46.9 vs. 27.4%; aOR: 2.27; 95% CI: 1.26, 4.08 and 64.2 vs. 46.5%; aOR: 2.08; 95% CI: 1.16, 3.72 respectively).<\/jats:p><jats:p>\n            Conclusion\u2003In people with HDP, a course of ACS given in the late preterm period did not improve neonatal morbidity.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0044-1788609","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T22:54:44Z","timestamp":1721861684000},"page":"342-349","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes in Pregnancies Complicated with Preterm Hypertensive Disorders with and without Late Antenatal Corticosteroids"],"prefix":"10.1055","volume":"42","author":[{"given":"Noam","family":"Regev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Axelrod","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Berkovitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakefet","family":"Yoeli-Ulman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shali","family":"Mazaki-Tovi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sivan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baha","family":"Sibai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Fishel Bartal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"issue":"05","key":"ref1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/AOG.0b013e3181a45b25","article-title":"Hypertensive disorders and severe obstetric morbidity in the United States","volume":"113","author":"E V Kuklina","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref3","first-page":"181","article-title":"Diagnosis and management of gestational hypertension and preeclampsia","volume":"102","author":"B M Sibai","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1097\/AOG.0000000000001711","article-title":"Practice bulletin no. 171: management of preterm labor","volume":"128","author":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins\u2014Obstetrics","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1097\/AOG.0000000000002237","article-title":"Committee opinion no. 713: antenatal corticosteroid therapy for fetal maturation","volume":"130","author":"Committee on Obstetric Practice","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJMoa1516783","article-title":"Antenatal betamethasone for women at risk for late preterm delivery","volume":"374","author":"C Gyamfi-Bannerman","year":"2016","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"i5044","DOI":"10.1136\/bmj.i5044","article-title":"Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials","volume":"355","author":"G Saccone","year":"2016","journal-title":"BMJ"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"B36","DOI":"10.1016\/j.ajog.2021.07.023","article-title":"Society for Maternal-Fetal Medicine Consult Series #58: use of antenatal corticosteroids for individuals at risk for late preterm delivery: replaces SMFM Statement #4, Implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery, August 2016","volume":"225","author":"U M Reddy","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"7802","key":"ref9","doi-asserted-by":"crossref","first-page":"d1696","DOI":"10.1136\/bmj.d1696","article-title":"Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial","volume":"342","author":"A MF Porto","year":"2011","journal-title":"BMJ"},{"issue":"04","key":"ref10","first-page":"468","article-title":"Late-preterm antenatal steroids for reduction of neonatal respiratory complications: a randomized controlled trial","volume":"143","author":"H Yenuberi","year":"2024","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ajog.2023.09.013","article-title":"Antenatal corticosteroids: an updated assessment of anticipated benefits and potential risks","volume":"230","author":"A H Jobe","year":"2024","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref12","first-page":"174","article-title":"Effectiveness of antenatal steroids in obstetric subgroups","volume":"93","author":"A Elimian","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/uog.26127","article-title":"Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort","volume":"61","author":"A Familiari","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222","volume":"135","author":"Gestational Hypertension and Preeclampsia","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref15","first-page":"311","article-title":"Birth weight standards in the live-born population in Israel","volume":"7","author":"S Dollberg","year":"2005","journal-title":"Isr Med Assoc J"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2013a prospective study","volume":"151","author":"F P Hadlock","year":"1985","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1542\/peds.50.4.515","article-title":"A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants","volume":"50","author":"G C Liggins","year":"1972","journal-title":"Pediatrics"},{"issue":"10","key":"ref18","first-page":"4979","article-title":"Reduced placental 11\u03b2-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms","volume":"86","author":"C L McTernan","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000263348","article-title":"Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses","volume":"3","author":"D L Economides","year":"1988","journal-title":"Fetal Ther"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000492859","article-title":"Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis","volume":"115","author":"R Shah","year":"2019","journal-title":"Neonatology"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1542\/peds.2005-1919","article-title":"Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study","volume":"117","author":"N Boluyt","year":"2006","journal-title":"Pediatrics"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"F195","DOI":"10.1136\/archdischild-2012-303157","article-title":"Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial)","volume":"98","author":"P R Stutchfield","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"19","key":"ref23","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2020.3937","article-title":"Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children","volume":"323","author":"K R\u00e4ikk\u00f6nen","year":"2020","journal-title":"JAMA"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/dev.20510","article-title":"Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants","volume":"53","author":"E P Davis","year":"2011","journal-title":"Dev Psychobiol"},{"issue":"07","key":"ref25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/er.2008-0014","article-title":"Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review","volume":"30","author":"M Tegethoff","year":"2009","journal-title":"Endocr Rev"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"S764","DOI":"10.1016\/j.ajog.2022.11.1305","article-title":"Neurodevelopmental outcomes after late preterm antenatal corticosteroids: the alps follow-up study","volume":"228","author":"C Gyamfi-Bannerman","year":"2023","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1788609.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T23:32:47Z","timestamp":1738711967000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1788609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":26,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,2,4]]},"published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1788609","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published":{"date-parts":[[2024,7,24]]}}}