{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:58:52Z","timestamp":1778086732806,"version":"3.51.4"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Central Council for Research in Homoeopathy, New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Objective\u2003The study was undertaken to evaluate the protective effect of Eupatorium perfoliatum (EP) 30C on the incidence of dengue fever.<\/jats:p><jats:p>\n               Design\u2003This study was designed as a prospective, open label, parallel cohort study.<\/jats:p><jats:p>\n               Interventions\u2003Participants were enrolled in two medicine cohort (MC) communities and one control cohort (CC) community. Participants in MC who were more than 5 years of age received four medicated globules and those aged between 1 and 5 years received two medicated globules of EP 30C once a week for 10 weeks. Participants in CC received no medical intervention. Both cohorts received information and educational material regarding dengue.<\/jats:p><jats:p>\n               Outcome Measures\u2003The primary outcome was incidence of dengue cases based on laboratory confirmation or the clinical definition of dengue as per the case definition notified by the National Vector-Borne Disease Control Program, Government of India, during the 14 weeks of intervention and observation.<\/jats:p><jats:p>\n               Results\u2003The analysis included 20,607 participants residing in three slums of Delhi, of which MC and CC included 15,298 and 5,309 participants respectively. The overall protective effect of EP 30C in MC against probable\/laboratory-confirmed dengue was 59.59% (95% confidence interval [CI], 50.74 to 66.85, p\u2009=\u20090.0001). The overall protective effect of EP 30C against laboratory-confirmed dengue was 72.78% (95% CI, 54.45 to 83.74, p\u2009=\u20090.0001): 26 cases per 15,298 (0.13 per 1,000 person-weeks) in MC versus 33 cases per 5,309 (0.46 per 1,000 person-weeks) in CC.<\/jats:p><jats:p>\n               Conclusion\u2003The use of EP 30C was associated with some protection against probable and laboratory-confirmed dengue.<\/jats:p>","DOI":"10.1055\/s-0044-1788663","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T19:04:23Z","timestamp":1729796663000},"page":"163-172","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of Eupatorium Perfoliatum 30C in Preventing Dengue Fever\u2014A Prospective, Community-Based, Open Label, Parallel Cohort Study in Delhi, India"],"prefix":"10.1055","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-8333","authenticated-orcid":false,"given":"Debadatta","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Epidemic Cell, Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovepreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Epidemic Cell, Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupali","family":"Bhalerao","sequence":"additional","affiliation":[{"name":"Ayurswasthya Yojana, Central Sector Scheme, Ministry of Ayush, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karanpreet","family":"Nahar","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Dr. D.P Rastogi Central Research Institute of Homoeopathy, Noida, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanuman","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Clinical Research Unit for Homoeopathy, Goa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Health and Family Welfare, State Homoeopathic Dispensary, Bagdogra, under Ayush Branch, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Delhi Government Homoeopathic Unit, Acharya Shree Bhikhshu Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Epidemic Cell, Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Khurana","sequence":"additional","affiliation":[{"name":"National Commission for Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj Kumar","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Directorate of AYUSH, Government of National Capital Territory of Delhi, Ayurvedic and Unani Tibbia College Campus, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"M G Guzman","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-7622-2-1","article-title":"Dengue fever: new paradigms for a changing epidemiology","volume":"2","author":"D Guha-Sapir","year":"2005","journal-title":"Emerg Themes Epidemiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e3306","DOI":"10.1371\/journal.pntd.0003306","article-title":"Approaches to refining estimates of global burden and economics of dengue","volume":"8","author":"D S Shepard","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4269\/ajtmh.14-0002","article-title":"Economic and disease burden of dengue illness in India","volume":"91","author":"D S Shepard","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"ref6","first-page":"62","article-title":"Trend and epidemiological profile of dengue fever\/dengue haemorrhagic fever in Ahmedabad City, Gujarat, India. 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