{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:35:13Z","timestamp":1784115313606,"version":"3.55.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Patients with severe coronavirus disease-19 (COVID-19) may require the use of invasive mechanical ventilation (MV) for prolonged periods. Aggressive MV parameters have been associated with changes in intracranial pressure (ICP) in patients with acute intracranial disorders. Significant ICP elevation could compromise intracranial compliance (ICC) and cerebrovascular hemodynamics (CVH). However, the effects of these parameters in individuals without neurological disorders have not yet been evaluated.<\/jats:p><jats:p>\n          Objective\u2003To evaluate ICC in patients on MV with COVID-19 infection compared to other diagnoses, to better characterize the effects of MV and COVID-19 upon ICC. We also compared between the ICC in patients with COVID-19 who did not require MV and healthy volunteers, to assess the isolated effect of COVID-19 upon ICC.<\/jats:p><jats:p>\n          Methods\u2003This was an exploratory, observational study with a convenience sample. The ICC was evaluated with a noninvasive ICP monitoring device. The P2\/P1 ratio was calculated by dividing the amplitude of these two points, being defined as \u201cabnormal\u201d when P2\u2009&gt;\u2009P1. The statistical analysis was performed using a mixed linear model with random effects to compare the P2\/P1 ratio in all four groups on the first monitoring day.<\/jats:p><jats:p>\n          Results\u2003A convenience sample of 78 subjects (15 MV-COVID-19, 15 MV non-COVID-19, 24 non-MV-COVID-19, and 24 healthy participants) was prospectively enrolled. There was no difference in P2\/P1 ratios between MV patients with and without COVID-19, nor between non-MV patients with COVID-19 and healthy volunteers. However, the P2\/P1 ratio was higher in COVID-19 patients with MV use than in those without it.<\/jats:p><jats:p>\n          Conclusion\u2003This exploratory analysis suggests that COVID-19 does not impair ICC.<\/jats:p>","DOI":"10.1055\/s-0044-1788669","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T23:03:21Z","timestamp":1723244601000},"page":"001-008","source":"Crossref","is-referenced-by-count":1,"title":["Intracranial compliance in patients with COVID-19: a multicenter observational study"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-9579","authenticated-orcid":false,"given":"Ana Fl\u00e1via","family":"Silveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Carlos, Departamento de Fisioterapia, S\u00e3o Carlos SP, 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Yukie","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-468X","authenticated-orcid":false,"given":"Gustavo Henrique Frigieri","family":"Vilela","sequence":"additional","affiliation":[{"name":"Braincare Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica S.A., Departamento Cientifico, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7776-3393","authenticated-orcid":false,"given":"Samantha Longhi Sim\u00f5es de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Hospital Samaritano Higienopolis, Unidades Terapia Intensiva, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-7164","authenticated-orcid":false,"given":"Jo\u00e3o Brainer Clares de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Neurologia e Neurocirurgia, S\u00e3o Paulo SP, Brazil."},{"name":"Centro Universit\u00e1rio S\u00e3o Camilo, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-5654","authenticated-orcid":false,"given":"Sal\u00f3mon","family":"Rojas","sequence":"additional","affiliation":[{"name":"Benefic\u00eancia Portuguesa Hospital, Divis\u00e3o da Unidade de Terapia Intensiva Neurol\u00f3gica, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2840","authenticated-orcid":false,"given":"Fabiano Moulin 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