{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:49:11Z","timestamp":1765889351401,"version":"3.40.5"},"reference-count":64,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombotic events striking the central nervous system are clinical criteria for the antiphospholipid syndrome (APS). Besides these, neuropsychiatric non-APS criteria manifestations are increasingly described in patients with persistently positive antiphospholipid antibodies (aPL). Among these are psychiatric manifestations. Animal models mainly describe hyperactive behavior and anxiety associated with hippocampal abnormalities. Cases of associations with psychosis, mood disorders, bipolarity, anxiety, obsessive\u2013compulsive behavior, and depression have been reported but are still rare. Systematic human clinical association studies are concordant with a risk of psychosis, depression (simple to major), and anxiety disorders, but these are limited and of inconstant methodological quality. Brain imaging in patients, also insufficiently investigated, shows early signs of hypoperfusion and of subtle diffuse white matter changes compatible with an alteration of the axonal structure and changes in the myelin sheath. Direct interactions of aPL with the brain cells, both on cell lines and on animal and human brain biopsies, targeting both glial cells, astrocytes, and neurons, can be demonstrated. These clusters of arguments make the association between psychiatric diseases and aPL increasingly plausible. However, a considerable amount of clinical research must still be performed in accordance with the highest standards of methodological quality. The therapeutic management of this association, in terms of both prevention and cure, currently remains unresolved.<\/jats:p>","DOI":"10.1055\/s-0044-1788696","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T23:05:22Z","timestamp":1721862322000},"page":"448-456","source":"Crossref","is-referenced-by-count":1,"title":["Antiphospholipid Antibodies in Mental Disorders"],"prefix":"10.1055","volume":"51","author":[{"given":"Jean-Christophe","family":"Gris","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Debrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France"},{"name":"Department of Obstetrics, Gynecology and Perinatal Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Ch\u00e9a","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Debrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Department of Hematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Debrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, CHU N\u00eemes, N\u00eemes, France"},{"name":"MIPA, University of N\u00eemes, N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.neuron.2012.06.002","article-title":"Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness","volume":"74","author":"J W Buckholtz","year":"2012","journal-title":"Neuron"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nm.4246","article-title":"Resting-state connectivity biomarkers define neurophysiological subtypes of depression","volume":"23","author":"A T Drysdale","year":"2017","journal-title":"Nat Med"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/s41380-020-0723-7","article-title":"A structural brain network of genetic vulnerability to psychiatric illness","volume":"26","author":"M Taquet","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/hbm.26077","article-title":"Deep multimodal predictome for studying mental disorders","volume":"44","author":"M A Rahaman","year":"2023","journal-title":"Hum Brain Mapp"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jtha.2022.12.006","article-title":"Venous thromboembolism and risk of depression: a population-based cohort study","volume":"21","author":"H J\u00f8rgensen","year":"2023","journal-title":"J Thromb Haemost"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055\/a-2225-5428","article-title":"Risk of depression after venous thromboembolism in patients with hematological cancer: a population-based cohort study","author":"D Steiner","year":"2023","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/biom11040562","article-title":"Role of thrombin in central nervous system injury and disease","volume":"11","author":"N A Shlobin","year":"2021","journal-title":"Biomolecules"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood-2007-06-096651","article-title":"The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells","volume":"110","author":"J S Bae","year":"2007","journal-title":"Blood"},{"issue":"6534","key":"ref10","doi-asserted-by":"crossref","first-page":"eabc0956","DOI":"10.1126\/science.abc0956","article-title":"Lipid presentation by the protein C receptor links coagulation with autoimmunity","volume":"371","author":"N M\u00fcller-Calleja","year":"2021","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaut.2018.03.001","article-title":"Mechanisms of neuropsychiatric lupus: The relative roles of the blood-cerebrospinal fluid barrier versus blood-brain barrier","volume":"91","author":"S Gelb","year":"2018","journal-title":"J Autoimmun"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1172\/JCI119572","article-title":"Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. 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