{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:21:47Z","timestamp":1792718507681,"version":"4.5.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diagnosing oral submucous fibrosis (OSMF) is invariably challenging. The disease can be detected after reaching its final stage and requires complex treatment. Changes in its salivary profile can be used as a reference to see this disorder and as a basis for diagnostic prediction. This study is aimed to analyze the salivary profile as a diagnosis marker in patients with OSMF. The study using Preferred Reporting Items for Systematic Reviews and Meta-analyses was conducted using PubMed, Science Direct, and Scopus databases. A thorough literature search between 1991 and 2023 was performed. Twenty-eight full-text articles were reviewed in detail. Twenty-eight articles were included; a total of 929 patients of OSMF and 826 controls were found. The scoping review showed that levels of salivary protein (including lactate hydrogenase, immunoglobulin G, immunoglobulin A, S1007A protein, 8-hydroxydeoxyguanosine, 8-isoprostane, malondialdehyde, matrix metalloproteinase-12, salivary C-reactive protein, fibrinogen producing factor, salivary miRNA-21, and salivary lipids [cholesterol, high-density lipoprotein, triglyceride) were higher in OSMF. Meanwhile, trace elements (vitamin C, vitamin E, iron, zinc, and magnesium) were lower; only copper was higher in OSMF patients. Alteration in salivary components such as protein, lipid, and trace elements detection can be a basis for providing a noninvasive supportive examination and thus be used as a diagnosis marker of OSMF.<\/jats:p>","DOI":"10.1055\/s-0044-1788711","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T23:04:55Z","timestamp":1722899095000},"page":"024-036","source":"Crossref","is-referenced-by-count":6,"title":["Salivary Profile in Oral Submucous Fibrosis: A Scoping Review"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-418X","authenticated-orcid":false,"given":"Fatma Yasmin","family":"Mahdani","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajiravudh","family":"Subarnbhesaj","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnosis, Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurina Febriyanti","family":"Ayuningtyas","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-2287","authenticated-orcid":false,"given":"Meircurius Dwi Condro","family":"Surboyo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiska Kumala","family":"Bakti","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiana","family":"Radithia","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimas Bayu","family":"Paramananda","sequence":"additional","affiliation":[{"name":"Bachelor of Dental Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Indriyani","sequence":"additional","affiliation":[{"name":"Bachelor of Dental Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah Fauzi","family":"Basalamah","sequence":"additional","affiliation":[{"name":"Oral Medicine Specialist Study Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 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