{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:30:52Z","timestamp":1775338252104,"version":"3.50.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Very few studies have examined the relationship between calcitonin gene-related peptide (CGRP) and amylin levels and the disease in patients with migraine. The purpose of this study was to compare blood CGRP and amylin levels between pediatric migraine patients and healthy controls and the relationship between CGRP and amylin levels and migraine attack frequency and duration.<\/jats:p><jats:p>\n          Materials and Methods\u2003The study involved two separate groups\u2014control and migraine. Thirty-two patients aged 6 to 18 years presenting to the Balikesir University Medical Faculty pediatric neurology clinic and diagnosed with migraine were included. The control group consisted of 32 patients without migraine presenting to the clinic during the same time frame. The patients' demographic data, personal and family histories, migraine type and frequency, headache severity, basic anthropometric measurements (height, weight, and body mass index), and physical and neurological examination findings were recorded. Migraine patients were classified as ictal if the collection of blood specimens coincided with the attack period and as interictal if this was performed between attacks.<\/jats:p><jats:p>\n          Results\u2003No statistically significant differences in mean CGRP or amylin levels were determined between the groups (migraine ictal\/interictal) or between the migraine patients (in terms of gender or attack frequency and duration).<\/jats:p><jats:p>\n          Conclusion\u2003Elucidating the complex processes involved in the pathogenesis of migraine is important in terms of our ability to develop new treatments and therapeutic strategies. This study aimed to evaluate CGRP and amylin levels in patients with pediatric migraine (in the ictal and interictal periods) compared with those in healthy controls.<\/jats:p>","DOI":"10.1055\/s-0044-1788787","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T23:03:00Z","timestamp":1723503780000},"page":"029-033","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Calcitonin Gene-Related Peptide and Amylin in Pediatric Migraine"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-1270","authenticated-orcid":false,"given":"Hilal","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-6900","authenticated-orcid":false,"given":"Ozg\u00fcr","family":"Baykan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/head.14153","article-title":"The American Headache Society Consensus Statement: update on integrating new migraine 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