{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:26:41Z","timestamp":1759184801766,"version":"3.28.0"},"reference-count":266,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"National Research Foundation of Korea Grant Funded by the Korean Government","award":["2022R1C1C1003563"],"award-info":[{"award-number":["2022R1C1C1003563"]}]},{"name":"National Research Foundation of Korea Grant Funded by the Korean Government","award":["2021R1C1C2004529"],"award-info":[{"award-number":["2021R1C1C2004529"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>This review explores the biological aspects of neutrophils, their contributions to the development of steatotic liver disease, and their potential as therapeutic targets for the disease. Although alcohol-associated and metabolic dysfunction-associated liver diseases originate from distinct etiological factors, the two diseases frequently share excessive lipid accumulation as a common contributor to their pathogenesis, thereby classifying them as types of steatotic liver disease. Dysregulated lipid deposition in the liver induces hepatic injury, triggering the activation of the innate immunity, partially through neutrophil recruitment. Traditionally recognized for their role in microbial clearance, neutrophils have recently garnered attention for their involvement in sterile inflammation, a pivotal component of steatotic liver disease pathogenesis. In conclusion, technological innovations, including single-cell RNA sequencing, have gradually disclosed the existence of various neutrophil subsets; however, how the distinct subsets of neutrophil population contribute differentially to the development of steatotic liver disease remains unclear.<\/jats:p>","DOI":"10.1055\/s-0044-1789207","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:28:17Z","timestamp":1723159697000},"page":"300-318","source":"Crossref","is-referenced-by-count":2,"title":["Role of Neutrophils in the Development of Steatotic Liver Disease"],"prefix":"10.1055","volume":"44","author":[{"given":"You-Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Daegu Catholic University, Gyeongsan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonghwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41423-020-00579-3","article-title":"Immunological mechanisms and therapeutic targets of fatty liver diseases","volume":"18","author":"H Wang","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol effects on hepatic lipid metabolism","volume":"61","author":"S Jeon","year":"2020","journal-title":"J Lipid Res"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.31518","article-title":"Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade","volume":"73","author":"H Tilg","year":"2021","journal-title":"Hepatology"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/ijms23020774","article-title":"Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease","volume":"23","author":"Y M Yang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12272-022-01379-1","article-title":"Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis","volume":"45","author":"K W Chung","year":"2022","journal-title":"Arch Pharm Res"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"J Hyun","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cld.2016.02.004","article-title":"Pathogenesis of alcoholic liver disease","volume":"20","author":"W Dunn","year":"2016","journal-title":"Clin Liver Dis"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cld.494","article-title":"Microbiome in NAFLD and ALD","volume":"6","author":"I A Kirpich","year":"2015","journal-title":"Clin Liver Dis (Hoboken)"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41575-019-0246-3","article-title":"Manipulating the gut microbiota to combat alcoholic hepatitis","volume":"17","author":"K Ray","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: an organ with predominant innate immunity","volume":"47","author":"B Gao","year":"2008","journal-title":"Hepatology"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"J S Bajaj","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref12","first-page":"332398","article-title":"Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinoma","author":"S Ha","year":"2024","journal-title":"Gut"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrgastro.2017.116","article-title":"Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations","volume":"15","author":"R Parker","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jhep.2023.12.007","article-title":"Adipose tissue macrophage dysfunction in human MASLD - Cause or consequence?","volume":"80","author":"F Colella","year":"2024","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"571085","DOI":"10.3389\/fimmu.2020.571085","article-title":"The neutrophil: constant defender and first responder","volume":"11","author":"N Fine","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.3390\/antiox11112302","article-title":"Myeloperoxidase: regulation of neutrophil function and target for therapy","volume":"11","author":"S A Rizo-T\u00e9llez","year":"2022","journal-title":"Antioxidants"},{"issue":"08","key":"ref17","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2016.01.025","article-title":"Inflammation in alcoholic and nonalcoholic fatty liver disease: Friend or foe?","volume":"150","author":"B Gao","year":"2016","journal-title":"Gastroenterology"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"A Bertola","year":"2013","journal-title":"Nat Protoc"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26419","article-title":"Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin","volume":"58","author":"A Bertola","year":"2013","journal-title":"Hepatology"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/cmi.2015.06","article-title":"Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration","volume":"13","author":"S Mathews","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.27921","article-title":"Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1","volume":"62","author":"B Chang","year":"2015","journal-title":"Hepatology"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.31031","article-title":"Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets","volume":"72","author":"S Hwang","year":"2020","journal-title":"Hepatology"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/hep.31390","article-title":"Protective and detrimental roles of p38\u03b1 mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease","volume":"72","author":"S Hwang","year":"2020","journal-title":"Hepatology"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"24194","DOI":"10.1038\/s41598-021-03679-w","article-title":"Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis","volume":"11","author":"A D Kim","year":"2021","journal-title":"Sci Rep"},{"issue":"20","key":"ref25","doi-asserted-by":"crossref","first-page":"15489","DOI":"10.3390\/ijms242015489","article-title":"Overexpression of interleukin-8 promotes the progression of fatty liver to nonalcoholic steatohepatitis in mice","volume":"24","author":"Y E Cho","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1038\/s41467-020-16596-9","article-title":"Durable and controlled depletion of neutrophils in mice","volume":"11","author":"G Boivin","year":"2020","journal-title":"Nat Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"666732","DOI":"10.3389\/fphar.2021.666732","article-title":"Phagocytosis, degranulation and extracellular traps release by neutrophils-the current knowledge, pharmacological modulation and future prospects","volume":"12","author":"B Gierlikowska","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance","volume":"7","author":"G T Nguyen","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"945749","DOI":"10.3389\/fcell.2022.945749","article-title":"Regulation of neutrophil NADPH oxidase, NOX2: a crucial effector in neutrophil phenotype and function","volume":"10","author":"M H Paclet","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.1038\/s41598-022-13825-7","article-title":"High generation of reactive oxygen species from neutrophils in patients with severe COVID-19","volume":"12","author":"T Veenith","year":"2022","journal-title":"Sci Rep"},{"issue":"07","key":"ref31","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.it.2019.05.003","article-title":"Biological roles of neutrophil-derived granule proteins and cytokines","volume":"40","author":"M A Cassatella","year":"2019","journal-title":"Trends Immunol"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41573-019-0054-z","article-title":"Neutrophils as emerging therapeutic targets","volume":"19","author":"T N\u00e9meth","year":"2020","journal-title":"Nat Rev Drug Discov"},{"issue":"07","key":"ref33","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"C T Pham","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fimmu.2014.00448","article-title":"Granule protein processing and regulated secretion in neutrophils","volume":"5","author":"A Sheshachalam","year":"2014","journal-title":"Front Immunol"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"e1009054","DOI":"10.1371\/journal.ppat.1009054","article-title":"Manipulating neutrophil degranulation as a bacterial virulence strategy","volume":"16","author":"K R Eichelberger","year":"2020","journal-title":"PLoS Pathog"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"112002","DOI":"10.1016\/j.biopha.2021.112002","article-title":"Lipocalin-2: structure, function, distribution and role in metabolic disorders","volume":"142","author":"S A Jaberi","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"03","key":"ref37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/diagnostics11030480","article-title":"Role of gelatinases MMP-2 and MMP-9 in healthy and complicated pregnancy and their future potential as preeclampsia biomarkers","volume":"11","author":"A Nikolov","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12974-018-1284-4","article-title":"The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease","volume":"15","author":"A J Stock","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"625472","DOI":"10.3389\/fimmu.2021.625472","article-title":"The roles of neutrophils in the pathogenesis of liver diseases","volume":"12","author":"J Tang","year":"2021","journal-title":"Front Immunol"},{"key":"ref40","first-page":"9254087","article-title":"Neutrophil extracellular traps: signaling properties and disease relevance","volume":"2020","author":"T Li","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"V Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"5663","key":"ref42","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"issue":"06","key":"ref43","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.4049\/jimmunol.1301539","article-title":"Processes of sterile inflammation","volume":"191","author":"H Shen","year":"2013","journal-title":"J Immunol"},{"issue":"18","key":"ref44","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1038\/onc.2016.406","article-title":"Neutrophil extracellular traps: protagonists of cancer progression?","volume":"36","author":"L Erpenbeck","year":"2017","journal-title":"Oncogene"},{"issue":"03","key":"ref45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"S K Jorch","year":"2017","journal-title":"Nat Med"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/hep.27841","article-title":"Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury","volume":"62","author":"H Huang","year":"2015","journal-title":"Hepatology"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/hep.29914","article-title":"Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis","volume":"68","author":"D J van der Windt","year":"2018","journal-title":"Hepatology"},{"issue":"06","key":"ref48","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"H Wang","year":"2021","journal-title":"J Hepatol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"175618","DOI":"10.1016\/j.ejphar.2023.175618","article-title":"Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis","volume":"945","author":"J Wu","year":"2023","journal-title":"Eur J Pharmacol"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"e1170","DOI":"10.1002\/ctm2.1170","article-title":"Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis","volume":"13","author":"H Zhang","year":"2023","journal-title":"Clin Transl Med"},{"issue":"05","key":"ref51","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jhep.2018.07.005","article-title":"Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use","volume":"69","author":"T N Bukong","year":"2018","journal-title":"J Hepatol"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00007890-197910000-00019","article-title":"Expression of H-2 and Ia antigens on mouse peritoneal neutrophils","volume":"28","author":"K Okuda","year":"1979","journal-title":"Transplantation"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00918005","article-title":"Interaction of Ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes","volume":"7","author":"J E Fitzgerald","year":"1983","journal-title":"Inflammation"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.imlet.2008.02.008","article-title":"Murine neutrophils present Class II restricted antigen","volume":"118","author":"S Culshaw","year":"2008","journal-title":"Immunol Lett"},{"issue":"05","key":"ref55","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1182\/blood-2005-03-1281","article-title":"Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes","volume":"106","author":"V Abadie","year":"2005","journal-title":"Blood"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1182\/blood-2009-11-254490","article-title":"CCR7 is involved in the migration of neutrophils to lymph nodes","volume":"117","author":"C Beauvillain","year":"2011","journal-title":"Blood"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","article-title":"Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair","volume":"10","author":"W Yang","year":"2019","journal-title":"Nat Commun"},{"issue":"04","key":"ref58","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gutjnl-2016-311861","article-title":"MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils","volume":"66","author":"M Li","year":"2017","journal-title":"Gut"},{"issue":"09","key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0153-7","article-title":"Role of miR-223 in the pathophysiology of liver diseases","volume":"50","author":"D Ye","year":"2018","journal-title":"Exp Mol Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2020.00532","article-title":"An attempt to polarize human neutrophils toward N1 and N2 phenotypes in vitro","volume":"11","author":"M Ohms","year":"2020","journal-title":"Front Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"708770","DOI":"10.3389\/fimmu.2021.708770","article-title":"Transcriptional profiling and functional analysis of N1\/N2 neutrophils reveal an immunomodulatory effect of S100A9-blockade on the pro-inflammatory N1 subpopulation","volume":"12","author":"A C Mihaila","year":"2021","journal-title":"Front Immunol"},{"issue":"24","key":"ref62","doi-asserted-by":"crossref","first-page":"15827","DOI":"10.3390\/ijms232415827","article-title":"Diverse neutrophil functions in cancer and promising neutrophil-based cancer therapies","volume":"23","author":"K Sounbuli","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3389\/fonc.2019.01146","article-title":"Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy","volume":"9","author":"M T Masucci","year":"2019","journal-title":"Front Oncol"},{"issue":"05","key":"ref64","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jcmgh.2023.06.012","article-title":"Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease","volume":"16","author":"X Mi","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"S A MacParland","year":"2018","journal-title":"Nat Commun"},{"issue":"05","key":"ref66","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1097\/HEP.0000000000000438","article-title":"Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients","volume":"78","author":"A S Genshaft","year":"2023","journal-title":"Hepatology"},{"issue":"09","key":"ref67","doi-asserted-by":"crossref","first-page":"e178616","DOI":"10.1172\/JCI178616","article-title":"IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis","volume":"134","author":"Y Guan","year":"2024","journal-title":"J Clin Invest"},{"issue":"01","key":"ref68","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"S K Asrani","year":"2019","journal-title":"J Hepatol"},{"issue":"01","key":"ref69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/biom7010009","article-title":"Key events participating in the pathogenesis of alcoholic liver disease","volume":"7","author":"F Magdaleno","year":"2017","journal-title":"Biomolecules"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1465-3362.2009.00153.x","article-title":"Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis","volume":"29","author":"J Rehm","year":"2010","journal-title":"Drug Alcohol Rev"},{"issue":"03","key":"ref71","doi-asserted-by":"crossref","first-page":"e176345","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"B Mackowiak","year":"2024","journal-title":"J Clin Invest"},{"issue":"04","key":"ref72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.livres.2017.12.004","article-title":"Targeting the gut barrier for the treatment of alcoholic liver disease","volume":"1","author":"Z Zhou","year":"2017","journal-title":"Liver Res"},{"issue":"07","key":"ref73","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/00365528309182111","article-title":"Escherichia coli antibodies in alcoholic liver disease. Correlation to alcohol consumption, alcoholic hepatitis, and serum IgA","volume":"18","author":"P Staun-Olsen","year":"1983","journal-title":"Scand J Gastroenterol"},{"issue":"01","key":"ref74","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1572-0241.1999.00797.x","article-title":"Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage","volume":"94","author":"A Keshavarzian","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"04","key":"ref75","first-page":"48S","article-title":"Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance","volume":"24","author":"M Fujimoto","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"issue":"02","key":"ref76","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1530-0277.2007.00584.x","article-title":"Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease","volume":"32","author":"Y Tang","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"issue":"05","key":"ref77","doi-asserted-by":"crossref","first-page":"e96864","DOI":"10.1371\/journal.pone.0096864","article-title":"Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals","volume":"9","author":"S Bala","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"ref78","doi-asserted-by":"crossref","first-page":"12900","DOI":"10.1096\/fj.201900491RR","article-title":"Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice","volume":"33","author":"P Gim\u00e9nez-G\u00f3mez","year":"2019","journal-title":"FASEB J"},{"issue":"6053","key":"ref79","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine","volume":"334","author":"S Vaishnava","year":"2011","journal-title":"Science"},{"issue":"7481","key":"ref80","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature12729","article-title":"Antibacterial membrane attack by a pore-forming intestinal C-type lectin","volume":"505","author":"S Mukherjee","year":"2014","journal-title":"Nature"},{"issue":"02","key":"ref81","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2016.01.003","article-title":"Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation","volume":"19","author":"L Wang","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"02","key":"ref82","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"B Gao","year":"2019","journal-title":"J Hepatol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"X Wu","year":"2023","journal-title":"Annu Rev Pathol"},{"issue":"01","key":"ref84","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jhep.2022.08.029","article-title":"Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis","volume":"78","author":"Y Cho","year":"2023","journal-title":"J Hepatol"},{"issue":"04","key":"ref85","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2023.05.017","article-title":"The role of neutrophils in alcohol-related hepatitis","volume":"79","author":"R S Khan","year":"2023","journal-title":"J Hepatol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pharmthera.2017.06.007","article-title":"Targeting inflammation for the treatment of alcoholic liver disease","volume":"180","author":"M J Xu","year":"2017","journal-title":"Pharmacol Ther"},{"issue":"32","key":"ref87","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"M You","year":"2002","journal-title":"J Biol Chem"},{"issue":"05","key":"ref88","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jhep.2006.05.009","article-title":"Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model","volume":"45","author":"C Ji","year":"2006","journal-title":"J Hepatol"},{"issue":"03","key":"ref89","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.taap.2007.06.018","article-title":"Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice","volume":"223","author":"H Q Yin","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"issue":"01","key":"ref90","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0168-8278(87)80003-X","article-title":"Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess","volume":"4","author":"C Bode","year":"1987","journal-title":"J Hepatol"},{"issue":"06","key":"ref91","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMP-activated protein kinase in the action of ethanol in the liver","volume":"127","author":"M You","year":"2004","journal-title":"Gastroenterology"},{"issue":"05","key":"ref92","first-page":"614","article-title":"TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)","volume":"232","author":"M Endo","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"issue":"04","key":"ref93","doi-asserted-by":"crossref","first-page":"G892","DOI":"10.1152\/ajpgi.00575.2007","article-title":"Involvement of mammalian sirtuin 1 in the action of ethanol in the liver","volume":"294","author":"M You","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"07","key":"ref94","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: a dysfunctional relationship","volume":"122","author":"J B Hoek","year":"2002","journal-title":"Gastroenterology"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1172\/JCI104366","article-title":"Studies on the pathogenesis of the ethanol-induced fatty liver. I. Synthesis and oxidation of fatty acids by the liver","volume":"40","author":"G Reboucas","year":"1961","journal-title":"J Clin Invest"},{"issue":"05","key":"ref96","doi-asserted-by":"crossref","first-page":"G483","DOI":"10.1152\/ajpgi.00281.2023","article-title":"Interaction between fatty acid oxidation and ethanol metabolism in liver","volume":"326","author":"Y Lu","year":"2024","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"21","key":"ref97","doi-asserted-by":"crossref","first-page":"16390","DOI":"10.1074\/jbc.M000953200","article-title":"The acute phase response is associated with retinoid X receptor repression in rodent liver","volume":"275","author":"A P Beigneux","year":"2000","journal-title":"J Biol Chem"},{"issue":"02","key":"ref98","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.metabol.2006.10.007","article-title":"Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells","volume":"56","author":"M S Kim","year":"2007","journal-title":"Metabolism"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0168-8278(01)00263-X","article-title":"Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats","volume":"36","author":"T Sugimoto","year":"2002","journal-title":"J Hepatol"},{"issue":"02","key":"ref100","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1074\/jbc.M412107200","article-title":"Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver","volume":"280","author":"C Am\u00e9en","year":"2005","journal-title":"J Biol Chem"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.freeradbiomed.2021.06.027","article-title":"Gut inflammation exacerbates high-fat diet induced steatosis by suppressing VLDL-TG secretion through HNF4\u03b1 pathway","volume":"172","author":"P Li","year":"2021","journal-title":"Free Radic Biol Med"},{"issue":"03","key":"ref102","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/hep.21737","article-title":"Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome","volume":"46","author":"R P Mookerjee","year":"2007","journal-title":"Hepatology"},{"issue":"02","key":"ref103","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hep.28897","article-title":"Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis","volume":"65","author":"S Das","year":"2017","journal-title":"Hepatology"},{"issue":"05","key":"ref104","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/hep.1840070513","article-title":"Elevation of chemotactic factor inactivator in alcoholic liver disease","volume":"7","author":"R A Robbins","year":"1987","journal-title":"Hepatology"},{"issue":"03","key":"ref105","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.1840180316","article-title":"Increased plasma interleukin-8 concentrations in alcoholic hepatitis","volume":"18","author":"D B Hill","year":"1993","journal-title":"Hepatology"},{"issue":"02","key":"ref106","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","article-title":"The interleukin-17 pathway is involved in human alcoholic liver disease","volume":"49","author":"A Lemmers","year":"2009","journal-title":"Hepatology"},{"issue":"03","key":"ref107","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.yexmp.2014.09.004","article-title":"Increased activity of the complement system in the liver of patients with alcoholic hepatitis","volume":"97","author":"H Shen","year":"2014","journal-title":"Exp Mol Pathol"},{"issue":"04","key":"ref108","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/jcp.35.4.380","article-title":"Circulating immune complexes and complement concentrations in patients with alcoholic liver disease","volume":"35","author":"C Gluud","year":"1982","journal-title":"J Clin Pathol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2016.01.021","article-title":"TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis","volume":"89","author":"K V Korneev","year":"2017","journal-title":"Cytokine"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"155828","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: an evolving chemokine","volume":"153","author":"K Matsushima","year":"2022","journal-title":"Cytokine"},{"issue":"11","key":"ref111","first-page":"180S","article-title":"Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease","volume":"29","author":"C McClain","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"05","key":"ref112","first-page":"CR215","article-title":"Interleukin-8 in the blood serum of patients with alcoholic liver disease","volume":"12","author":"R Swiatkowska-Stodulska","year":"2006","journal-title":"Med Sci Monit"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.alcohol.2019.11.005","article-title":"Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-\u03b1","volume":"85","author":"A T Hillmer","year":"2020","journal-title":"Alcohol"},{"issue":"06","key":"ref114","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.7150\/thno.15625","article-title":"Role of the CXCL8-CXCR1\/2 axis in cancer and inflammatory diseases","volume":"7","author":"H Ha","year":"2017","journal-title":"Theranostics"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"155402","DOI":"10.1016\/j.cyto.2020.155402","article-title":"IL-8 exacerbates alcohol-induced fatty liver disease via the Akt\/HIF-1\u03b1 pathway in human IL-8-expressing mice","volume":"138","author":"Z Wang","year":"2021","journal-title":"Cytokine"},{"issue":"04","key":"ref116","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"J K Kolls","year":"2004","journal-title":"Immunity"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"C T Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"03","key":"ref118","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/hep.31321","article-title":"Inhibition of sphingosine-1-phosphate-induced Th17 cells ameliorates alcohol-associated steatohepatitis in mice","volume":"73","author":"S Chu","year":"2021","journal-title":"Hepatology"},{"issue":"01","key":"ref119","first-page":"41","article-title":"Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration","volume":"18","author":"N Sheron","year":"1993","journal-title":"Hepatology"},{"issue":"02","key":"ref120","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1053\/j.gastro.2006.12.036","article-title":"Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity","volume":"132","author":"J Colmenero","year":"2007","journal-title":"Gastroenterology"},{"issue":"03","key":"ref121","doi-asserted-by":"crossref","first-page":"e131277","DOI":"10.1172\/jci.insight.131277","article-title":"Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice","volume":"5","author":"J Xu","year":"2020","journal-title":"JCI Insight"},{"issue":"06","key":"ref122","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ni.2031","article-title":"The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF","volume":"12","author":"M El-Behi","year":"2011","journal-title":"Nat Immunol"},{"issue":"09","key":"ref123","doi-asserted-by":"crossref","first-page":"e0274582","DOI":"10.1371\/journal.pone.0274582","article-title":"IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models","volume":"17","author":"J E Heredia","year":"2022","journal-title":"PLoS One"},{"issue":"01","key":"ref124","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"G Szabo","year":"2015","journal-title":"Gastroenterology"},{"issue":"01","key":"ref125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"A W Yan","year":"2011","journal-title":"Hepatology"},{"issue":"42","key":"ref126","doi-asserted-by":"crossref","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","article-title":"Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity","volume":"111","author":"S Leclercq","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"06","key":"ref127","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.ajpath.2011.08.039","article-title":"Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury","volume":"179","author":"Y Wang","year":"2011","journal-title":"Am J Pathol"},{"issue":"05","key":"ref128","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2015-310585","article-title":"Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease","volume":"65","author":"M Llopis","year":"2016","journal-title":"Gut"},{"issue":"04","key":"ref129","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","article-title":"Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice","volume":"66","author":"G Ferrere","year":"2017","journal-title":"J Hepatol"},{"issue":"01","key":"ref130","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12974-018-1328-9","article-title":"Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression","volume":"15","author":"P P Lowe","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"115923","DOI":"10.1016\/j.taap.2022.115923","article-title":"Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg\/Th1 cells","volume":"439","author":"Y Zhu","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"issue":"04","key":"ref132","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.32608","article-title":"Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation","volume":"77","author":"M Jiang","year":"2023","journal-title":"Hepatology"},{"issue":"06","key":"ref133","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jhep.2009.03.007","article-title":"Signalling pathways in alcohol-induced liver inflammation","volume":"50","author":"P Mandrekar","year":"2009","journal-title":"J Hepatol"},{"issue":"05","key":"ref134","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"B Gao","year":"2011","journal-title":"Gastroenterology"},{"issue":"03","key":"ref135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2018.10.041","article-title":"Alcohol-related liver disease: areas of consensus, unmet needs and opportunities for further study","volume":"70","author":"M Thursz","year":"2019","journal-title":"J Hepatol"},{"issue":"04","key":"ref136","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gutjnl-2019-319720","article-title":"Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting","volume":"69","author":"M A Avila","year":"2020","journal-title":"Gut"},{"issue":"06","key":"ref137","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.4049\/jimmunol.168.6.2963","article-title":"Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice","volume":"168","author":"T Uesugi","year":"2002","journal-title":"J Immunol"},{"issue":"04","key":"ref138","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/hep.22470","article-title":"The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88","volume":"48","author":"I Hritz","year":"2008","journal-title":"Hepatology"},{"issue":"05","key":"ref139","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"J S Bajaj","year":"2014","journal-title":"J Hepatol"},{"issue":"02","key":"ref140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2478(02)00228-6","article-title":"Recognition of pathogen-associated molecular patterns by TLR family","volume":"85","author":"S Akira","year":"2003","journal-title":"Immunol Lett"},{"issue":"01","key":"ref141","doi-asserted-by":"crossref","first-page":"G30","DOI":"10.1152\/ajpgi.00031.2015","article-title":"TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration","volume":"309","author":"Y S Roh","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"03","key":"ref142","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/hep.31800","article-title":"Stress-responsive gene FK506-binding protein 51 mediates alcohol-induced liver injury through the hippo pathway and chemokine (C-X-C motif) ligand 1 signaling","volume":"74","author":"P Kusumanchi","year":"2021","journal-title":"Hepatology"},{"issue":"05","key":"ref143","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.21138","article-title":"Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver","volume":"43","author":"T Gustot","year":"2006","journal-title":"Hepatology"},{"issue":"01","key":"ref144","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chom.2019.11.001","article-title":"Roseburia sppabundance associates with alcohol consumption in humans and its administration ameliorates alcoholic fatty liver in mice","volume":"27","author":"B Seo","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"01","key":"ref145","doi-asserted-by":"crossref","first-page":"1782157","DOI":"10.1080\/19490976.2020.1782157","article-title":"Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans","volume":"12","author":"L Maccioni","year":"2020","journal-title":"Gut Microbes"},{"issue":"04","key":"ref146","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jhep.2015.11.037","article-title":"Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease","volume":"64","author":"V Wieser","year":"2016","journal-title":"J Hepatol"},{"issue":"01","key":"ref147","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jhep.2017.08.023","article-title":"IL-1 receptor like 1 protects against alcoholic liver injury by limiting NF-\u03baB activation in hepatic macrophages","volume":"68","author":"M Wang","year":"2017","journal-title":"J Hepatol"},{"issue":"07","key":"ref148","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00109-020-01926-7","article-title":"Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1\u03b2 and IL-17 upregulation in alcoholic hepatitis mice","volume":"98","author":"A Eguchi","year":"2020","journal-title":"J Mol Med (Berl)"},{"issue":"01","key":"ref149","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/hep.31680","article-title":"Two faces of neutrophils in liver disease development and progression","volume":"74","author":"Y Cho","year":"2021","journal-title":"Hepatology"},{"issue":"10","key":"ref150","doi-asserted-by":"crossref","first-page":"e0257","DOI":"10.1097\/HC9.0000000000000257","article-title":"Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis","volume":"7","author":"S Tang","year":"2023","journal-title":"Hepatol Commun"},{"issue":"05","key":"ref151","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/gutjnl-2015-310344","article-title":"Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors","volume":"66","author":"V Wieser","year":"2017","journal-title":"Gut"},{"issue":"09","key":"ref152","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.ajpath.2016.05.006","article-title":"The detrimental role played by lipocalin-2 in alcoholic fatty liver in mice","volume":"186","author":"Y Cai","year":"2016","journal-title":"Am J Pathol"},{"issue":"06","key":"ref153","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jhep.2019.12.017","article-title":"IL-33\/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis","volume":"72","author":"F Artru","year":"2020","journal-title":"J Hepatol"},{"issue":"04","key":"ref154","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0168-8278(00)80219-6","article-title":"Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids","volume":"32","author":"J Ta\u00efeb","year":"2000","journal-title":"J Hepatol"},{"issue":"02","key":"ref155","first-page":"361","article-title":"Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide","volume":"25","author":"A Casini","year":"1997","journal-title":"Hepatology"},{"issue":"03","key":"ref156","doi-asserted-by":"crossref","first-page":"G203","DOI":"10.1152\/ajpgi.00112.2016","article-title":"Dysfunctional neutrophil effector organelle mobilization and microbicidal protein release in alcohol-related cirrhosis","volume":"313","author":"T H Tranah","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"03","key":"ref157","doi-asserted-by":"crossref","first-page":"e16592","DOI":"10.15252\/emmm.202216592","article-title":"Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking","volume":"15","author":"N Li","year":"2023","journal-title":"EMBO Mol Med"},{"issue":"02","key":"ref158","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.toxlet.2013.03.007","article-title":"Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils","volume":"219","author":"M Freitas","year":"2013","journal-title":"Toxicol Lett"},{"issue":"10","key":"ref159","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"C J Calvente","year":"2019","journal-title":"J Clin Invest"},{"issue":"03","key":"ref160","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0168-8278(01)00276-8","article-title":"Polymorphonuclear neutrophils are a source of hepatocyte growth factor in patients with severe alcoholic hepatitis","volume":"36","author":"J Ta\u00efeb","year":"2002","journal-title":"J Hepatol"},{"issue":"03","key":"ref161","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.32152","article-title":"Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C\/EBP\u03b1-miRNA-223 axis","volume":"75","author":"R Ren","year":"2022","journal-title":"Hepatology"},{"issue":"14","key":"ref162","doi-asserted-by":"crossref","first-page":"e157780","DOI":"10.1172\/JCI157780","article-title":"Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure","volume":"132","author":"J Ma","year":"2022","journal-title":"J Clin Invest"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/jgh.12032","article-title":"Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease","volume":"28","author":"X Kong","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"02","key":"ref164","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/hep.31046","article-title":"An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis","volume":"72","author":"J P Arab","year":"2020","journal-title":"Hepatology"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"156293","DOI":"10.1016\/j.cyto.2023.156293","article-title":"IL-22 as a target for therapeutic intervention: current knowledge on its role in various diseases","volume":"169","author":"P Seth","year":"2023","journal-title":"Cytokine"},{"issue":"01","key":"ref166","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/hep.22317","article-title":"Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial","volume":"48","author":"L Spahr","year":"2008","journal-title":"Hepatology"},{"issue":"09","key":"ref167","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/ajg.2014.154","article-title":"Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study","volume":"109","author":"V Singh","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"ref168","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.cgh.2018.06.013","article-title":"Is granulocyte colony stimulating factor a new treatment for alcoholic hepatitis?","volume":"16","author":"T R Morgan","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref169","doi-asserted-by":"crossref","first-page":"101516","DOI":"10.1016\/j.smim.2021.101516","article-title":"G-CSF - a double edge sword in neutrophil mediated immunity","volume":"54","author":"K R Martin","year":"2021","journal-title":"Semin Immunol"},{"issue":"03","key":"ref170","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.26109","article-title":"Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis","volume":"57","author":"L Rolas","year":"2013","journal-title":"Hepatology"},{"issue":"02","key":"ref171","first-page":"152","article-title":"Infections in severe alcoholic hepatitis","volume":"30","author":"E Karakike","year":"2017","journal-title":"Ann Gastroenterol"},{"issue":"09","key":"ref172","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1002\/hep4.1925","article-title":"Granulocyte colony-stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice","volume":"6","author":"Y Cho","year":"2022","journal-title":"Hepatol Commun"},{"issue":"10","key":"ref173","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3748\/wjg.v20.i10.2542","article-title":"Risk factors and outcome of bacterial infections in cirrhosis","volume":"20","author":"T Bruns","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"03","key":"ref174","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.30516","article-title":"Efficacy of granulocyte colony-stimulating factor in the management of steroid-nonresponsive severe alcoholic hepatitis: a double-blind randomized controlled trial","volume":"70","author":"S M Shasthry","year":"2019","journal-title":"Hepatology"},{"key":"ref175","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pharmthera.2019.03.001","article-title":"Alcohol abuse and disorder of granulopoiesis","volume":"198","author":"X Shi","year":"2019","journal-title":"Pharmacol Ther"},{"issue":"7182","key":"ref176","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223","volume":"451","author":"J B Johnnidis","year":"2008","journal-title":"Nature"},{"issue":"01","key":"ref177","doi-asserted-by":"crossref","first-page":"G32","DOI":"10.1152\/ajpgi.00024.2012","article-title":"Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury","volume":"303","author":"Y Wang","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"03","key":"ref178","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.toxlet.2015.03.002","article-title":"Inhibition of miR122a by Lactobacillus rhamnosus GG culture supernatant increases intestinal occludin expression and protects mice from alcoholic liver disease","volume":"234","author":"H Zhao","year":"2015","journal-title":"Toxicol Lett"},{"issue":"02","key":"ref179","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alcohol.2008.12.009","article-title":"Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis","volume":"43","author":"C B Forsyth","year":"2009","journal-title":"Alcohol"},{"issue":"05","key":"ref180","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep4.1679","article-title":"Exosome-like nanoparticles from Lactobacillus rhamnosus GG protect against alcohol-associated liver disease through intestinal aryl hydrocarbon receptor in mice","volume":"5","author":"Z Gu","year":"2021","journal-title":"Hepatol Commun"},{"issue":"04","key":"ref181","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.4049\/jimmunol.1302286","article-title":"Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps","volume":"192","author":"L Vong","year":"2014","journal-title":"J Immunol"},{"issue":"04","key":"ref182","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.celrep.2014.12.039","article-title":"Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer","volume":"10","author":"J Y Sagiv","year":"2015","journal-title":"Cell Rep"},{"issue":"42","key":"ref183","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.3748\/wjg.v16.i42.5286","article-title":"Histopathology of nonalcoholic fatty liver disease","volume":"16","author":"E M Brunt","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"05","key":"ref184","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/hep.23594","article-title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection","volume":"51","author":"B Q Starley","year":"2010","journal-title":"Hepatology"},{"key":"ref185","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3389\/fimmu.2020.01500","article-title":"Roles of hepatic innate and innate-like lymphocytes in nonalcoholic steatohepatitis","volume":"11","author":"Y Chen","year":"2020","journal-title":"Front Immunol"},{"key":"ref186","doi-asserted-by":"crossref","first-page":"603926","DOI":"10.3389\/fphar.2020.603926","article-title":"Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments","volume":"11","author":"C Peng","year":"2020","journal-title":"Front Pharmacol"},{"issue":"12","key":"ref187","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.cgh.2021.12.002","article-title":"2019 Global NAFLD prevalence: a systematic review and meta-analysis","volume":"20","author":"M H Le","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"06","key":"ref188","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Q M Anstee","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"01","key":"ref189","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Z Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"08","key":"ref190","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"E Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"05","key":"ref191","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"K L Donnelly","year":"2005","journal-title":"J Clin Invest"},{"issue":"07","key":"ref192","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"S L Friedman","year":"2018","journal-title":"Nat Med"},{"issue":"02","key":"ref193","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1262-3636(07)70098-8","article-title":"The ins and outs of mitochondrial dysfunction in NASH","volume":"30","author":"B Fromenty","year":"2004","journal-title":"Diabetes Metab"},{"issue":"02","key":"ref194","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/j.gastro.2007.11.038","article-title":"Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease","volume":"134","author":"E Fabbrini","year":"2008","journal-title":"Gastroenterology"},{"issue":"03","key":"ref195","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"C Postic","year":"2008","journal-title":"J Clin Invest"},{"issue":"08","key":"ref196","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tem.2012.04.005","article-title":"Role of ceramides in nonalcoholic fatty liver disease","volume":"23","author":"M Pagadala","year":"2012","journal-title":"Trends Endocrinol Metab"},{"issue":"04","key":"ref197","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/nutrit\/nux004","article-title":"Dietary sphingolipids: potential for management of dyslipidemia and nonalcoholic fatty liver disease","volume":"75","author":"G H Norris","year":"2017","journal-title":"Nutr Rev"},{"issue":"02","key":"ref198","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.1152\/ajpendo.00644.2005","article-title":"Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells","volume":"291","author":"Y Wei","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"17","key":"ref199","doi-asserted-by":"crossref","first-page":"12093","DOI":"10.1074\/jbc.M510660200","article-title":"Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis","volume":"281","author":"H Malhi","year":"2006","journal-title":"J Biol Chem"},{"issue":"05","key":"ref200","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/hep.22183","article-title":"The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity","volume":"47","author":"Z Li","year":"2008","journal-title":"Hepatology"},{"issue":"18","key":"ref201","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"D H Ipsen","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"09","key":"ref202","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"P Rada","year":"2020","journal-title":"Cell Death Dis"},{"issue":"18","key":"ref203","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.molcel.2021.08.027","article-title":"Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity","volume":"81","author":"H Yoon","year":"2021","journal-title":"Mol Cell"},{"issue":"04","key":"ref204","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"M Peiseler","year":"2022","journal-title":"J Hepatol"},{"issue":"02","key":"ref205","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/gut.48.2.206","article-title":"The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis","volume":"48","author":"A J Wigg","year":"2001","journal-title":"Gut"},{"issue":"06","key":"ref206","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"L Miele","year":"2009","journal-title":"Hepatology"},{"issue":"01","key":"ref207","doi-asserted-by":"crossref","first-page":"2304157","DOI":"10.1080\/19490976.2024.2304157","article-title":"Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus","volume":"16","author":"R Forlano","year":"2024","journal-title":"Gut Microbes"},{"issue":"02","key":"ref208","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH","volume":"57","author":"L Zhu","year":"2013","journal-title":"Hepatology"},{"key":"ref209","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1038\/srep08096","article-title":"Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease","volume":"5","author":"W Jiang","year":"2015","journal-title":"Sci Rep"},{"issue":"05","key":"ref210","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s10620-016-4049-x","article-title":"Innate immunity and inflammation in NAFLD\/NASH","volume":"61","author":"M Arrese","year":"2016","journal-title":"Dig Dis Sci"},{"issue":"12","key":"ref211","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"H Tilg","year":"2021","journal-title":"Nat Metab"},{"issue":"48","key":"ref212","doi-asserted-by":"crossref","first-page":"40161","DOI":"10.1074\/jbc.M112.417014","article-title":"Kupffer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-\u03b1 production","volume":"287","author":"A C Tosello-Trampont","year":"2012","journal-title":"J Biol Chem"},{"issue":"03","key":"ref213","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"F Marra","year":"2014","journal-title":"Gastroenterology"},{"issue":"01","key":"ref214","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"K R Karlmark","year":"2009","journal-title":"Hepatology"},{"issue":"46","key":"ref215","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"P Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"03","key":"ref216","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"K Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"04","key":"ref217","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2353\/ajpath.2009.080999","article-title":"Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis","volume":"175","author":"S S Rensen","year":"2009","journal-title":"Am J Pathol"},{"issue":"02","key":"ref218","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1478-3231.2011.02639.x","article-title":"Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease","volume":"32","author":"N Alkhouri","year":"2012","journal-title":"Liver Int"},{"issue":"04","key":"ref219","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.26937","article-title":"The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease","volume":"59","author":"V L Gadd","year":"2014","journal-title":"Hepatology"},{"issue":"02","key":"ref220","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s12013-015-0682-9","article-title":"Neutrophils play a crucial role in the early stage of nonalcoholic steatohepatitis via neutrophil elastase in mice","volume":"73","author":"S Zang","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"09","key":"ref221","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/MEG.0000000000001393","article-title":"Neutrophil-to-lymphocyte ratio is independently associated with inflammatory activity and fibrosis grade in nonalcoholic fatty liver disease","volume":"31","author":"T Khoury","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"05","key":"ref222","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41419-020-2582-1","article-title":"Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling","volume":"11","author":"X Zhao","year":"2020","journal-title":"Cell Death Dis"},{"issue":"07","key":"ref223","doi-asserted-by":"crossref","first-page":"e1325","DOI":"10.1002\/ctm2.1325","article-title":"Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis-induced formation of neutrophil extracellular traps","volume":"13","author":"T Lv","year":"2023","journal-title":"Clin Transl Med"},{"issue":"07","key":"ref224","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/gutjnl-2016-313654","article-title":"Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice","volume":"67","author":"M Bijnen","year":"2018","journal-title":"Gut"},{"issue":"05","key":"ref225","doi-asserted-by":"crossref","first-page":"536","DOI":"10.15252\/embj.201591857","article-title":"p38\u03b3 and p38\u03b4 reprogram liver metabolism by modulating neutrophil infiltration","volume":"35","author":"B Gonz\u00e1lez-Ter\u00e1n","year":"2016","journal-title":"EMBO J"},{"issue":"09","key":"ref226","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"S Talukdar","year":"2012","journal-title":"Nat Med"},{"issue":"12","key":"ref227","doi-asserted-by":"crossref","first-page":"e52411","DOI":"10.1371\/journal.pone.0052411","article-title":"Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice","volume":"7","author":"S S Rensen","year":"2012","journal-title":"PLoS One"},{"issue":"04","key":"ref228","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbrc.2019.08.111","article-title":"Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism","volume":"518","author":"J Chen","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"ref229","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj20030715","article-title":"Fragmentation of extracellular matrix by hypochlorous acid","volume":"376","author":"A A Woods","year":"2003","journal-title":"Biochem J"},{"issue":"02","key":"ref230","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0405193102","article-title":"Myeloperoxidase mediates neutrophil activation by association with CD11b\/CD18 integrins","volume":"102","author":"D Lau","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"02","key":"ref231","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0032-1331696","article-title":"Liver lipocalin 2 expression in severely obese women with non alcoholic fatty liver disease","volume":"121","author":"T Auguet","year":"2013","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"08","key":"ref232","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/1354750X.2015.1123354","article-title":"The potential of lipocalin-2\/NGAL as biomarker for inflammatory and metabolic diseases","volume":"20","author":"V Abella","year":"2015","journal-title":"Biomarkers"},{"issue":"05","key":"ref233","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jhep.2016.05.041","article-title":"Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2","volume":"65","author":"D Ye","year":"2016","journal-title":"J Hepatol"},{"issue":"05","key":"ref234","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tem.2017.01.003","article-title":"Lipocalin-2: a master mediator of intestinal and metabolic inflammation","volume":"28","author":"A R Moschen","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"ref235","doi-asserted-by":"crossref","first-page":"113626","DOI":"10.1016\/j.bcp.2019.113626","article-title":"Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications","volume":"169","author":"A Bhusal","year":"2019","journal-title":"Biochem Pharmacol"},{"issue":"03","key":"ref236","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00428-022-03330-7","article-title":"Neutrophil extracellular traps enriched with IL-1\u03b2 and IL-17A participate in the hepatic inflammatory process of patients with non-alcoholic steatohepatitis","volume":"481","author":"S Arelaki","year":"2022","journal-title":"Virchows Arch"},{"issue":"01","key":"ref237","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Y Koyama","year":"2017","journal-title":"J Clin Invest"},{"issue":"03","key":"ref238","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcmgh.2018.01.003","article-title":"Neutrophil-hepatic stellate cell interactions promote fibrosis in experimental steatohepatitis","volume":"5","author":"Z Zhou","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref239","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000762","article-title":"Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC","author":"Y Xia","year":"2024","journal-title":"Hepatology"},{"issue":"04","key":"ref240","first-page":"G847","article-title":"Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo","volume":"275","author":"J J Maher","year":"1998","journal-title":"Am J Physiol"},{"issue":"03","key":"ref241","doi-asserted-by":"crossref","first-page":"e0151063","DOI":"10.1371\/journal.pone.0151063","article-title":"TLR4-dependent secretion by hepatic stellate cells of the neutrophil-chemoattractant CXCL1 mediates liver response to gut microbiota","volume":"11","author":"A E Bigorgne","year":"2016","journal-title":"PLoS One"},{"issue":"05","key":"ref242","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/emmm.201202382","article-title":"Resolution of inflammation: an integrated view","volume":"5","author":"A Ortega-G\u00f3mez","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"03","key":"ref243","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.imbio.2012.05.021","article-title":"Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages","volume":"218","author":"C Eken","year":"2013","journal-title":"Immunobiology"},{"issue":"15","key":"ref244","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1182\/blood-2012-04-423525","article-title":"Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators","volume":"120","author":"J Dalli","year":"2012","journal-title":"Blood"},{"issue":"06","key":"ref245","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41419-018-0710-y","article-title":"Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-\u03baB activation","volume":"9","author":"J A Marwick","year":"2018","journal-title":"Cell Death Dis"},{"issue":"6658","key":"ref246","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/37022","article-title":"Immunosuppressive effects of apoptotic cells","volume":"390","author":"R E Voll","year":"1997","journal-title":"Nature"},{"issue":"04","key":"ref247","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF","volume":"101","author":"V A Fadok","year":"1998","journal-title":"J Clin Invest"},{"issue":"01","key":"ref248","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1038\/s41598-020-69634-3","article-title":"Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice","volume":"10","author":"J Wang","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"ref249","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep4.1566","article-title":"Therapeutic targeting of myeloperoxidase attenuates NASH in mice","volume":"4","author":"A C Koop","year":"2020","journal-title":"Hepatol Commun"},{"issue":"43","key":"ref250","doi-asserted-by":"crossref","first-page":"37578","DOI":"10.1074\/jbc.M111.266981","article-title":"2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation","volume":"286","author":"A K Tid\u00e9n","year":"2011","journal-title":"J Biol Chem"},{"issue":"01","key":"ref251","doi-asserted-by":"crossref","first-page":"101697","DOI":"10.1016\/j.clinre.2021.101697","article-title":"Neutrophil extracellular traps induced by pro-inflammatory cytokines enhance procoagulant activity in NASH patients","volume":"46","author":"J Du","year":"2022","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"10","key":"ref252","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1136\/gutjnl-2021-326259","article-title":"CXCR2 inhibition enables NASH-HCC immunotherapy","volume":"71","author":"J Leslie","year":"2022","journal-title":"Gut"},{"issue":"08","key":"ref253","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1201516","article-title":"NLRP3 inflammasome activity is negatively controlled by miR-223","volume":"189","author":"F Bauernfeind","year":"2012","journal-title":"J Immunol"},{"issue":"01","key":"ref254","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1651-2227.1991.tb11721.x","article-title":"The utility of infancy weight curves for the prediction of linear growth retardation in preschool children","volume":"80","author":"K B Simondon","year":"1991","journal-title":"Acta Paediatr Scand"},{"issue":"03","key":"ref255","doi-asserted-by":"crossref","first-page":"e141513","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"Y He","year":"2021","journal-title":"J Clin Invest"},{"issue":"01","key":"ref256","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.31658","article-title":"Myeloid-cell-specific IL-6 signaling promotes microRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis","volume":"74","author":"X Hou","year":"2021","journal-title":"Hepatology"},{"issue":"02","key":"ref257","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ymthe.2019.09.013","article-title":"MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury","volume":"28","author":"C Jimenez Calvente","year":"2020","journal-title":"Mol Ther"},{"issue":"01","key":"ref258","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/21623945.2022.2098583","article-title":"Adipose-derived mesenchymal stem cell-secreted extracellular vesicles alleviate non-alcoholic fatty liver disease via delivering miR-223-3p","volume":"11","author":"Q Niu","year":"2022","journal-title":"Adipocyte"},{"key":"ref259","doi-asserted-by":"crossref","first-page":"781815","DOI":"10.3389\/fimmu.2021.781815","article-title":"miR-223: an immune regulator in infectious disorders","volume":"12","author":"S Yuan","year":"2021","journal-title":"Front Immunol"},{"issue":"04","key":"ref260","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jhep.2014.11.025","article-title":"Roles of alcohol consumption in fatty liver: a longitudinal study","volume":"62","author":"A Moriya","year":"2015","journal-title":"J Hepatol"},{"issue":"02","key":"ref261","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2018.04.034","article-title":"Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study","volume":"155","author":"E Vilar-Gomez","year":"2018","journal-title":"Gastroenterology"},{"issue":"01","key":"ref262","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/hep.30170","article-title":"Nonheavy drinking and worsening of noninvasive fibrosis markers in nonalcoholic fatty liver disease: a cohort study","volume":"69","author":"Y Chang","year":"2019","journal-title":"Hepatology"},{"key":"ref263","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ebiom.2019.03.046","article-title":"Obesity in acute alcoholic hepatitis increases morbidity and mortality","volume":"45","author":"R Parker","year":"2019","journal-title":"EBioMedicine"},{"issue":"02","key":"ref264","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/apt.17846","article-title":"Implications of the new nomenclature of steatotic liver disease and definition of metabolic dysfunction-associated steatotic liver disease","volume":"59","author":"R Loomba","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"issue":"04","key":"ref265","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3350\/cmh.2023.0277","article-title":"Critical appraisal of metabolic dysfunction-associated steatotic liver disease: Implication of Janus-faced modernity","volume":"29","author":"G A Kim","year":"2023","journal-title":"Clin Mol Hepatol"},{"issue":"03","key":"ref266","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3727\/105221617X695519","article-title":"Animal models of alcoholic liver disease: pathogenesis and clinical relevance","volume":"17","author":"B Gao","year":"2017","journal-title":"Gene Expr"}],"container-title":["Seminars in Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1789207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:16:59Z","timestamp":1730823419000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1789207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":266,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,10,3]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1789207","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0272-8087","1098-8971"],"issn-type":[{"type":"print","value":"0272-8087"},{"type":"electronic","value":"1098-8971"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}