{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:45:31Z","timestamp":1784641531217,"version":"3.55.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Chronic subdural hematoma (cSDH) is common, predominantly affects the elderly, often recurs after treatment, and can have serious complications, including death. Inflammation plays an important role in cSDH and it has been previously shown that some laboratory indices are useful as prognostic markers. The aim was to research the role of hematologic and inflammatory markers in cSDH.<\/jats:p><jats:p>\n          Materials and Methods\u2003A single-center archival database review to retrieve data on cSDH cases operated on between 2018 and 2020, including: (1) sociodemography (age, gender), (2) clinics (Glasgow Coma Score [GCS], anticoagulants, chronic conditions), (3) laboratory (leukocyte, neutrophil, platelet, C-reactive protein, hemoglobin, red cell distribution width [RDW], neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio [PLR], systemic immune-inflammatory index [SII]), (4) cSDH (size, location, midline shift), and (5) treatment (craniotomy\/craniostomy, drainage). Primary outcome was Glasgow Outcome Score (GOS) at discharge and at 1 year, and secondary outcomes were 1 year mortality, resurgery, and recurrence. Hematological and inflammatory indices were compared across two cSDH thickness groups.<\/jats:p><jats:p>\n          Results\u2003Seventy-two patients were included, 25 women and 47 men, median age 77 years. Seventeen (23.6%) patients had chronic anticoagulant treatment. The majority had a chronic comorbidity: 19 (26.4%) diabetes, 48 (66.7%) hypertension, and 56 (77.8%) other chronic diseases. Median preoperative GCS was 15. Median cSDH thickness was 22.9\u2009mm, sidedness was equally distributed, and midline shift occurred in 60 (83.3\u2009%) patients, with median midline shift of 8.4\u2009mm. The majority of patients underwent a single craniostomy (n\u2009=\u200944, 61.1%), and in all patients a subdural drainage was placed. Median GOS at discharge and at 1 year postoperatively was 5. Mortality was 11.1%, and 16.7% of patients were lost to follow-up. Within the 1-year follow-up, 27.8% of patients had disease recurrence, 25% underwent a repeat surgery. In the \u201cabove\u201d versus \u201cbelow\u201d 15\u2009mm cSDH thickness group there were significant differences in P count (211.5 vs. 279.5\u2009\u00d7\u2009109\/L, p\u2009=\u20090.009), RDW (13.3 vs. 12.6, p\u2009=\u20090.031), SII (1782 vs. 2653, p\u2009=\u20090.025), and PLR (26.2 vs. 36.7, p\u2009=\u20090.042).<\/jats:p><jats:p>\n          Conclusion\u2003Hematological indices bear a diagnostic and prognostic potential in cSDH management.<\/jats:p>","DOI":"10.1055\/s-0044-1790237","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T23:03:36Z","timestamp":1726009416000},"page":"735-740","source":"Crossref","is-referenced-by-count":5,"title":["Hematologic Indices and Chronic Subdural Hematoma: A Single-Center Cohort Study"],"prefix":"10.1055","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8841-8457","authenticated-orcid":false,"given":"Hrvoje","family":"Bari\u0107","sequence":"additional","affiliation":[{"name":"Department of 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Neurological Surgery, Department of Surgery, Lagos, State University Teaching Hospital, Ikeja, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Desnica","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Mrak","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/SLA.0000000000000255","article-title":"Chronic subdural hematoma management: a systematic review and meta-analysis of 34,829 patients","volume":"259","author":"S A Almenawer","year":"2014","journal-title":"Ann 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