{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:57:56Z","timestamp":1790279876156,"version":"4.1.0"},"reference-count":72,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) face infection risk. The study evaluates vancomycin-loaded calcium sulfate bone as infection prevention. Patients with RA treated with TKA who had their femoral canal filled using either vancomycin-loaded calcium sulfate bone (experimental group [n\u2009=\u200935]) or the patient's own excised autologous bone (control group [n\u2009=\u200930]) at the Qingdao University Affiliated Hospital, Qingdao, China from January 1, 2017, to March 1, 2023, were retrospectively enrolled in this study. An experienced surgeon used midvastus approach. Surgeries included disinfection, antibiotics, and femoral filling. The age, gender, body mass index (BMI), comorbidities, and intraoperative details were extracted from the patient's medical records. Preoperation and postoperation markers (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]), pain scale (Visual Analog Scale [VAS]), infection rate, and Knee Society Score (KSS) were collected. Groups matched in age, gender, and BMI. No preoperative inflammatory marker differences were observed. However, compared to the control group, the postoperative inflammatory markers were significantly lower in the experimental group at 1-week postsurgery (CRP: 40.80\u2009\u00b1\u200923.17 vs. 60.80\u2009\u00b1\u200943.12\u2009mg\/L, p\u2009=\u20090.021; ESR: 72.06\u2009\u00b1\u200917.52 vs. 83.87\u2009\u00b1\u200921.52\u2009mm\/h, p\u2009=\u20090.012) and at 1-month postsurgery (CRP: 15.63\u2009\u00b1\u20096.56 vs. 21.17\u2009\u00b1\u200913.16\u2009mg\/L, p\u2009=\u20090.032; ESR: 25.25\u2009\u00b1\u200920.44 vs. 38.40\u2009\u00b1\u200925.26\u2009mm\/h, p\u2009=\u20090.024). There were no significant differences in the VAS (2.79\u2009\u00b1\u20090.90 vs. 2.70\u2009\u00b1\u20090.84 score, p\u2009=\u20090.689) and KSS (64.31\u2009\u00b1\u200917.88 vs. 66.57\u2009\u00b1\u200912.36) at 1-month postsurgery. Experimental group: zero infections; control group: only one infection. Administering vancomycin and calcium sulfate during TKA in RA patients reduces postoperative inflammation, but does not significantly affect infection risk; further research may be necessary for validation.<\/jats:p>","DOI":"10.1055\/s-0044-1790243","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T02:49:11Z","timestamp":1727491751000},"page":"013-021","source":"Crossref","is-referenced-by-count":5,"title":["Inflammatory Marker Changes Following Total Knee Arthroplasty for Rheumatoid Arthritis with Vancomycin-Loaded Calcium Sulfate Bone Filling"],"prefix":"10.1055","volume":"38","author":[{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuanHong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanxian Central Hospital, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Haici Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Qingdao Municipal Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1136\/ard.2008.096362","article-title":"Orthopaedic surgery in 255 patients with inflammatory arthropathies: longitudinal effects on pain, physical function and health-related quality of life","volume":"68","author":"H Osnes-Ringen","year":"2009","journal-title":"Ann Rheum 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