{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:00:37Z","timestamp":1769162437800,"version":"3.49.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Uterine fibroids are benign gynecological tumours that arise in the uterine smooth muscle tissue and are characterized by the production of excessive quantities of extracellular matrix. Various therapeutic options, from medical management to surgical intervention, exist for uterine fibroids, for which homeopathy has emerged as a promising therapeutic option in patient-centered care.<\/jats:p>\n                  <jats:p>A 40-year-old woman presented with complaints of heavy menstrual bleeding, with pain in the pelvic region and back. She was diagnosed as a case of bulky uterus with uterine fibroid. The patient opted for homeopathic management and was prescribed Thuja occidentalis based on individualization, miasmatic analysis and repertorial totality.<\/jats:p>\n                  <jats:p>After treatment, there was regression in size of the fibroid within 5 months, with complete resolution and restoration of the uterus to normal size within 9 months. Changes were validated through ultrasonography, which added objective evidence to the positive outcome. The Modified Naranjo Criteria for Homeopathy (MONARCH) inventory total score was +9, which indicated causal attribution of clinical outcome to the homeopathic intervention.<\/jats:p>\n                  <jats:p>This case study has illustrated the clinical benefits of homeopathy in the management of a patient with uterine fibroids, reaffirming the need for further research to explore its value as a therapeutic option for individuals seeking alternative or complementary approaches for appropriate medical conditions.<\/jats:p>","DOI":"10.1055\/s-0044-1790513","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T19:29:21Z","timestamp":1735586961000},"page":"254-260","source":"Crossref","is-referenced-by-count":1,"title":["Homeopathic Management of Bulky Uterus with Uterine Fibroid in a 40-year-old Patient: An Evidence-Based Case Report"],"prefix":"10.1055","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-4614","authenticated-orcid":false,"given":"Bharti","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta Singh","family":"Kureel","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research in Homoeopathy, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1056\/NEJMra1209993","article-title":"Uterine fibroids","volume":"369","author":"S E Bulun","year":"2013","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e63909","DOI":"10.1371\/journal.pone.0063909","article-title":"Gene expression in uterine leiomyoma from tumors likely to be growing (from black women over 35) and tumors likely to be non-growing (from white women over 35)","volume":"8","author":"B J Davis","year":"2013","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"E A Stewart","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.humpath.2018.06.013","article-title":"MED12 is frequently mutated in ovarian and other adnexal leiomyomas","volume":"81","author":"Z Li","year":"2018","journal-title":"Hum Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"D D Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"E A Stewart","year":"2017","journal-title":"BJOG"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.18203\/2320-1770.ijrcog20190278","article-title":"Predictors and symptomatic burden of uterine fibroids among women in South-Eastern India: a cross-sectional survey analysis","volume":"8","author":"D Swain","year":"2019","journal-title":"Int J Reprod Contracept Obstet Gynecol"},{"key":"ref8","first-page":"181","article-title":"The genetic bases of uterine fibroids; a review","volume":"12","author":"V Medikare","year":"2011","journal-title":"J Reprod Infertil"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1158\/0008-5472.CAN-04-0050","article-title":"Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF","volume":"64","author":"S D Moore","year":"2004","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1289\/ehp.5787","article-title":"Etiology and pathogenesis of uterine leiomyomas: a review","volume":"111","author":"G P Flake","year":"2003","journal-title":"Environ Health Perspect"},{"key":"ref11","first-page":"3249","article-title":"Environmental exposure and risk of uterine leiomyoma: an epidemiologic survey","volume":"17","author":"Y Shen","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-0037-1607264","article-title":"Uterine fibroids: burden and unmet medical need","volume":"35","author":"A Al-Hendy","year":"2017","journal-title":"Semin Reprod Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/jascp.jascp_38_22","article-title":"Aurum muriaticum natronatum in treatment of uterine fibroids: a randomized trial","volume":"4","author":"J Luthra","year":"2023","journal-title":"J Appl Sci Clin Pract"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/0974-7168.179148","article-title":"A multicentric randomized clinical trial of homoeopathic medicines in fifty millesimal potencies vis-\u00e0-vis centesimal potencies on symptomatic uterine fibroids","volume":"10","author":"P Oberai","year":"2016","journal-title":"Indian J Res Homoeopathy"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.53945\/2320-7094.1684","article-title":"Role of homoeopathic medicines in treating uterine fibroid: a prospective observational study","volume":"6","author":"I J Quadri","year":"2012","journal-title":"Ind J Res Homoeopathy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.25259\/JISH_22_2023","article-title":"Management of uterine fibroid with homoeopathy: a case report","volume":"6","author":"B P Maiti","year":"2023","journal-title":"J Intgr Stand Homoeopathy"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.53945\/2320-7094.1067","article-title":"Polycystic ovarian syndrome with endometrial hyperplasia and uterine fibroids treated with homoeopathy: a case report","volume":"16","author":"V Shinde","year":"2022","journal-title":"Indian J Res Homoeopathy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.53945\/2320-7094.1848","article-title":"A case of uterine fibroid","volume":"2","author":"J Quadri Iqbal","year":"2008","journal-title":"Indian J Res Homoeopathy"},{"key":"ref19","volume-title":"The Principles and Art of Cure by Homeopathy. Third Edition","author":"H A Roberts","year":"2002"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ctim.2015.12.019","article-title":"Homeopathic clinical case reports: Development of a supplement (HOM-CASE) to the CARE clinical case reporting guideline","volume":"25","author":"R A van Haselen","year":"2016","journal-title":"Complement Ther Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0040-1701251","article-title":"Evaluation of the Modified Naranjo Criteria for assessing causal attribution of clinical outcome to homeopathic intervention as presented in case reports","volume":"109","author":"C D Lamba","year":"2020","journal-title":"Homeopathy"},{"key":"ref22","volume-title":"Dictionary of Practical Materia Medica. Reprint ed","author":"J H Clarke","year":"1999"},{"key":"ref23","volume-title":"Vaccinosis and its Cure by Thuja: With Remarks on Homeoprophylaxis. Fifth Edition","author":"J C Burnett","year":"2021"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/B978-0-7020-5514-0.00086-5","volume-title":"The Clinician's Handbook of Natural Medicine. Third Edition","author":"J E Pizzorno","year":"2016"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.3390\/molecules25225416","article-title":"Thuja occidentalis L. (Cupressaceae): ethnobotany, phytochemistry and biological activity","volume":"25","author":"S Caruntu","year":"2020","journal-title":"Molecules"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jep.2015.03.029","article-title":"Thuja occidentalis L. and its active compound, \u03b1-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis","volume":"168","author":"E K Akkol","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13669-018-0243-5","article-title":"Natural history of uterine fibroids: a radiological perspective","volume":"7","author":"S Ghosh","year":"2018","journal-title":"Curr Obstet Gynecol Rep"}],"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1790513.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T22:30:55Z","timestamp":1761258655000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1790513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":27,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,10,23]]},"published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1790513","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}