{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:50:53Z","timestamp":1783947053532,"version":"3.55.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Hypoxic-ischemic encephalopathy (HIE) affects 1.5 newborns per 1 thousand term live births. Therapeutic hypothermia (TH) does not prevent all adverse outcomes. The experience with TH is still limited in Latin America. In Rio de Janeiro, Hospital Universit\u00e1rio Pedro Ernesto treats neonates with HIE since 2017 using the servo-controlled system.<\/jats:p><jats:p>\n          Objective\u2003To describe the frequency of epilepsy, altered neurological exam, and neurodevelopmental delay at 12 months of age in patients treated with TH in a reference hospital in Rio de Janeiro and to evaluate the possible risk associations with clinical data and data from complementary exams.<\/jats:p><jats:p>\n          Methods\u2003We evaluated medical records from the Neonatal Intensive Care Unit hospitalization and from first evaluation recorded at 12 months of age in the High-Risk Neonate Follow-up Outpatient Sevice.<\/jats:p><jats:p>\n          Results\u2003A total of 30 subjects were included in the study. We found epilepsy in 18.2% of the patients, altered neurological exam in 40.9%, and neurodevelopmental delay in 36.4%. We also found a significant relationship between altered magnetic resonance imaging scan and subsequent altered neurological exam. Our findings are in line with those of the international literature, which shows that adverse outcomes are still observed, even when TH is applied. Brazilian data shows our limited access to complementary exams. The rate of loss to follow-up was of 26.6%, probably due to the coronavirus disease 2019 (COVID-19) pandemic and to unfavorable socioeconomic conditions. More time for prospective follow-up and protocol adjustments should contribute to improve our data.<\/jats:p><jats:p>\n          Conclusion\u2003High incidences of epilepsy, altered neurological exams, and neurodevelopmental delay were found, despite the use of TH. A more efficient use of resources is needed, as well as measures such as early intervention.<\/jats:p>","DOI":"10.1055\/s-0044-1790575","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T22:33:48Z","timestamp":1727562828000},"page":"001-008","source":"Crossref","is-referenced-by-count":2,"title":["Neurological outcomes in neonates treated with therapeutic hypothermia: challenges in a developing country"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-406X","authenticated-orcid":false,"given":"Rita Farias","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Gaffr\u00e9e e Guinle, Departamento de Pediatria, Rio de Janeiro RJ, Brazil."},{"name":"Hospital Universit\u00e1rio Pedro Ernesto, Departamento de Pediatria, Rio de Janeiro RJ, Brazil."},{"name":"Universidade Federal do Estado do Rio de Janeiro, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3847-7208","authenticated-orcid":false,"given":"Lucia Helena","family":"Wagner","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Pedro Ernesto, Departamento de Pediatria, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-4111","authenticated-orcid":false,"given":"Alexandre Sousa da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Escola de Matem\u00e1tica, Departamento de M\u00e9todos Quantitativos, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-1949","authenticated-orcid":false,"given":"Maura Calixto Cecherelli de","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, Faculdade de Medicina, Departamento de Pediatria, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-0769","authenticated-orcid":false,"given":"Glenda Corr\u00eaa Borges de","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1212\/CON.0000000000000557","article-title":"Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies","volume":"24","author":"H C Glass","year":"2018","journal-title":"Continuum (Minneap Minn)"},{"issue":"10","key":"ref2","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. 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