{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:36:41Z","timestamp":1784993801342,"version":"3.55.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n            Background\u2003Transcatheter mitral valve repair is performed in a patient population at risk for thrombotic and bleeding events. The effects on platelet function and reactivity and their association with bleeding events after mitral transcatheter edge-to-edge therapy (M-TEER) have not been systematically examined.<\/jats:p><jats:p>\n            Objectives\u2003We sought to investigate the association of different parameters of platelet function and thrombogenicity with bleeding events post M-TEER.<\/jats:p><jats:p>\n            Methods\u2003In this single-center study, 100 consecutive patients with mitral regurgitation receiving TEER were analyzed. Blood was taken directly from the guide-catheter in the left atrium before and after placing the device. Blood samples were analyzed using impedance aggregometry (Multiplate) and TEG6s. The results were compared pre- and postprocedural. The primary outcome was any bleeding complication according to the Bleeding Academic Research Consortium classification within 6 months.<\/jats:p><jats:p>\n            Results\u2003A total of 41 patients experienced bleeding events. TEG analysis showed a significant decrease in ADP aggregation and increase in ADP inhibition. In ROC-analysis, TEG ADP aggregation and inhibition and Multiplate ADP aggregation showed moderate predictive values for bleeding events. The delta-ADP-Test (Multiplate) showed the strongest prediction of bleeding (area under the curve: 0.69). Adding platelet function and TEG markers to a model of clinical bleeding risk factors improved the prediction for bleeding events.<\/jats:p><jats:p>\n            Conclusion\u2003This study indicates that thrombogenicity might be affected immediately after M-TEER probably due to changes in flow conditions. In particular, platelet aggregation involving the ADP receptor pathway significantly correlated with postprocedural bleeding events. Whether these results could guide peri-interventional antithrombotic therapy and improve peri- and postprocedural outcome requires further investigation.<\/jats:p>","DOI":"10.1055\/s-0044-1790604","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T23:01:04Z","timestamp":1726700464000},"page":"130-141","source":"Crossref","is-referenced-by-count":1,"title":["Dynamics of Thrombogenicity and Platelet Function and Correlation with Bleeding Risk in Patients Undergoing M-TEER Using the PASCAL System"],"prefix":"10.1055","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-7718","authenticated-orcid":false,"given":"Miriam","family":"Euper","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Schreieck","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Bladt","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Zdanyte","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Goldschmied","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Sigle","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-2131","authenticated-orcid":false,"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-1451","authenticated-orcid":false,"given":"Diana A.","family":"Gorog","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia Ravn","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Departement of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Departement of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jacc.2009.03.077","article-title":"Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort","volume":"54","author":"T Feldman","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"ref2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"T Feldman","year":"2011","journal-title":"N Engl J Med"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11886-021-01553-9","article-title":"Complications following MitraClip implantation","volume":"23","author":"K Schnitzler","year":"2021","journal-title":"Curr Cardiol Rep"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.amjcard.2017.09.027","article-title":"Bleeding complications after percutaneous mitral valve repair with the MitraClip","volume":"121","author":"M I K\u00f6rber","year":"2018","journal-title":"Am J Cardiol"},{"key":"ref5","first-page":"100707","article-title":"Impact of bleeding complications after transcatheter mitral valve repair","volume":"32","author":"M Paukovitsch","year":"2021","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/00015385.2018.1550886","article-title":"Temporary oral anticoagulation after MitraClip - a strategy to lower the incidence of post-procedural stroke?","volume":"75","author":"N Geis","year":"2020","journal-title":"Acta 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Ndrepepa","year":"2012","journal-title":"Circulation"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"91B","DOI":"10.1016\/j.amjcard.2013.01.232","article-title":"Impact of in-hospital bleeding on major adverse cardiac events and stroke using Bleeding Academic Research Consortium Classification in patients who undergoing percutaneous coronary intervention","volume":"111","author":"Y H Yoon","year":"2013","journal-title":"Am J Cardiol"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the mitral valve Academic Research Consortium","volume":"66","author":"G W Stone","year":"2015","journal-title":"J Am Coll Cardiol"}],"container-title":["Thrombosis and 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