{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:46Z","timestamp":1740142426997,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Migraine belongs to the group of primary headaches, affecting 14.4% of the global population. The pathophysiological mechanisms of migraine involve the interplay between hypothalamic activation, cortical spreading depression, trigeminal stimulation, and inflammatory components with neurogenic inflammation or neuroinflammation.<\/jats:p><jats:p>\n          Objective\u2003To assess the frequency of the IL1A -899C\u2009&gt;\u2009T (rs1800587) genetic variant in patients with migraine and healthy controls, as well as its association with the clinical manifestations of migraine.<\/jats:p><jats:p>\n          Methods\u2003We conducted a case-control study involving 92 migraine patients and 88 healthy controls matched for age, sex, body mass index (BMI), and ethnicity. Demographic, anthropometric, and clinical data were obtained. The IL1A -889C\u2009&gt;\u2009T (rs1800587) variant was identified using real-time polymerase chain reaction.<\/jats:p><jats:p>\n          Results\u2003The study comprised predominantly women and Caucasian individuals, with no significant differences in terms of age, sex, ethnicity, or BMI observed between the migraine and control groups. Within the migraine group, 57.6% had episodic migraines, and 45.7% experienced aura. The patients carrying the CT genotype showed stronger associations with the presence of aura (CT: 57.7%; TT: 27.5%; p\u2009=\u20090.027), and those carrying the CT and TT genotypes showed higher osmophobia rates when compared with the CC genotype (p\u2009=\u20090.003). The IL1A -889C\u2009&gt;\u2009T genetic variant was not associated with migraine susceptibility, be it chronic or episodic, nor to other symptoms associated with migraine.<\/jats:p><jats:p>\n          Conclusion\u2003The IL1A -889C\u2009&gt;\u2009T genetic variant was associated with aura and osmophobia in migraine patients.<\/jats:p>","DOI":"10.1055\/s-0044-1791200","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:12:20Z","timestamp":1730938340000},"page":"001-007","source":"Crossref","is-referenced-by-count":0,"title":["Aura and osmophobia are associated with the IL1A -889C\u2009&gt;\u2009T (rs1800587) variant in migraine"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-7727","authenticated-orcid":false,"given":"Amanda Brant","family":"Rocha","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-575X","authenticated-orcid":false,"given":"Giovana Ortiz","family":"Zendrini","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-1232","authenticated-orcid":false,"given":"Maria Paula Bertoletti","family":"Juliani","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-4606","authenticated-orcid":false,"given":"Regina C\u00e9lia Poli","family":"Frederico","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-6218","authenticated-orcid":false,"given":"Val\u00e9ria Aparecida","family":"Bello","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0502-2255","authenticated-orcid":false,"given":"Carlos Eduardo Coral de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-2839","authenticated-orcid":false,"given":"Edna Maria Vissoci","family":"Reiche","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-9227","authenticated-orcid":false,"given":"Aline","family":"Vitali-Silva","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Faculdade de Medicina, Departamento de Medicina, Londrina PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 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