{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:09:25Z","timestamp":1785391765252,"version":"3.55.0"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Objective\u2003Chronic light exposure is associated with poorer mental and physical health. Many groups are chronically exposed to light due to their work schedule, including night-shift nurses. The present study aims to determine if middle-aged female mice have an increased vulnerability to chronic light exposure compared with younger individuals.<\/jats:p><jats:p>\n               Materials and Methods\u2003Young and middle-age female mice were housed in cages with or without running wheels and were exposed to either a 12:12-hour light:dark cycle or constant light (LL). All mice were assayed for circadian locomotor activity and anxiety-like behaviors, and weight, food consumption, and estrogen receptor beta (ER\u03b2) levels were measured.<\/jats:p><jats:p>\n               Results\u2003Middle-aged mice exhibited longer circadian periods in LL, reduced circadian power, and increased food consumption compared with young mice. LL increased novelty-induced activity and reduced ER\u03b2 regardless of age.<\/jats:p><jats:p>\n               Discussion\u2003These results indicate that middle-aged females may have an increased susceptibility to the negative circadian consequences caused by constant bright light exposure.<\/jats:p>","DOI":"10.1055\/s-0044-1791234","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T19:10:31Z","timestamp":1746731431000},"page":"e201-e208","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Constant Light and Running-Wheel Access in Middle-Aged Female C57BL6\/J Mice"],"prefix":"10.1055","volume":"18","author":[{"given":"Fernanda Medeiros","family":"Contini","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha G.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bridgewater State University, Bridgewater, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bridgewater State University, Bridgewater, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"McFarland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bridgewater State University, Bridgewater, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bridgewater State University, Bridgewater, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cloey 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