{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:42:47Z","timestamp":1790887367018,"version":"4.1.0"},"reference-count":65,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Objective\u2003To explore the preferences of medical practitioners concerning various medications and other remedies to manage insomnia, and to ascertain whether these preferences are associated with their respective medical specialties.<\/jats:p><jats:p>\n               Materials and Methods\u2003Employing the snowball sampling technique, we administered two versions of a questionnaire to an international group of medical professionals, including trainees and specialists from diverse medical backgrounds.<\/jats:p><jats:p>\n               Results\u2003Zopiclone, zolpidem, and mirtazapine were evaluated as the most effective treatments for insomnia, while physicians would typically avoid using other tricyclic antidepressants, dual orexin receptor antagonists, and tryptophan for insomnia treatment. Noteworthy statistical correlations between physicians' specialty and preferred drug therapy, were observed in three out of five cases: 1) first-line drug treatment for short-term intervention against insomnia; (2) second-line treatment for long-term intervention; and 3) cases involving the elderly.<\/jats:p><jats:p>\n               Discussion\u2003Psychiatrists demonstrated a greater preference for antipsychotics and antidepressants for the treatment of insomnia compared with other physicians. Conversely, other medical professionals exhibited a preference for benzodiazepines and Z-drugs (zopiclone and zolpidem). Although Z-drugs were evaluated as the most effective in the treatment of insomnia, in the clinical practice, physicians administer or would administer antidepressant or antipsychotic drugs more often (mirtazapine and quetiapine respectively). Regarding Dual Orexin Receptor Antagonists (DORAs), the high prevalence of \u201cDo not know\/No opinion\u201d answers implies that our sample was not familiar with this innovative treatment.<\/jats:p>","DOI":"10.1055\/s-0044-1791238","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T18:56:30Z","timestamp":1729709790000},"page":"e155-e164","source":"Crossref","is-referenced-by-count":2,"title":["Medical Professionals and Pharmacological Intervention for the Treatment of Insomnia: A Cross-Sectional Study"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4282-6206","authenticated-orcid":false,"given":"Antonios","family":"Liaskopoulos","sequence":"additional","affiliation":[{"name":"Psychological Applications in Health Postgraduate Studies, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-2985","authenticated-orcid":false,"given":"Vasileios","family":"Kakouris","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Philosophy, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0688-9842","authenticated-orcid":false,"given":"Nikolaos","family":"Liaskopoulos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"},{"name":"Psychiatric Clinic, General University Hospital of Larissa, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-6496","authenticated-orcid":false,"given":"Andreas S.","family":"Lappas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"},{"name":"Department of Geriatric Psychiatry, Aneurin Bevan University Health Board, Newport, Wales, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-0828","authenticated-orcid":false,"given":"Nikolaos","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-5091","authenticated-orcid":false,"given":"Myrto","family":"Samara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, 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Matheson","year":"2017","journal-title":"Am Fam Physician"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/wps.20674","article-title":"The assessment and management of insomnia: an update","volume":"18","author":"A D Krystal","year":"2019","journal-title":"World Psychiatry"},{"issue":"06","key":"ref9","first-page":"675","article-title":"European guideline for the diagnosis and treatment of insomnia. 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Efficacy of melatonin and ramelteon for the acute and long-term management of insomnia disorder in adults: A systematic review and meta-analysis","volume":"x","author":"J Maruani","year":"2023","journal-title":"J Sleep Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sleep.2019.02.017","article-title":"Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials","volume":"68","author":"S Wei","year":"2020","journal-title":"Sleep Med"},{"issue":"06","key":"ref45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/0272989X18785159","article-title":"Reducing \u201cI Don't Know\u201d Responses and Missing Survey Data: Implications for Measurement","volume":"38","author":"D C Denman","year":"2018","journal-title":"Med Decis Making"},{"issue":"07","key":"ref46","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S2215-0366(20)30136-X","article-title":"Sleep 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implications","volume":"10","author":"P L Franzen","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.smrv.2009.09.003","article-title":"Comorbidity of insomnia and depression","volume":"14","author":"L Staner","year":"2010","journal-title":"Sleep Med Rev"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.35351\/gebu.2022.10.17","article-title":"New drug: daridorexant for insomnia","volume":"75\u201378","author":"L Stolk","year":"2022","journal-title":"Ge-Bu."},{"issue":"02","key":"ref52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00228-019-02783-1","article-title":"Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks-a hospital survey","volume":"76","author":"S Heinemann","year":"2020","journal-title":"Eur J Clin 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