{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:47Z","timestamp":1740142427516,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Within the general epilepsy population, the incidence of Sudden Unexpected Death in Epilepsy (SUDEP) ranges from approximately 0.35 to 2.3 per 1,000 individuals per year.<\/jats:p><jats:p>\n          Objective\u2003We aimed to evaluate the relationship between SUDEP risk factors and heart rate variability (HRV) parameters as a potential biomarker of SUDEP in patients with drug-resistant epilepsy (DRE).<\/jats:p><jats:p>\n          Methods\u2003There were 52 patients diagnosed with DRE and under follow-up, and controls including 45 healthy subjects, included in the study. Hyperventilation-induced HRV (HRVHV) parameters, including the standard deviation of all RR intervals (SDRR), mean heart rate (HR), root mean squares of successive differences (RMSSD), SD of mean NN intervals recordings (SDANN), and HRV triangular index, were assessed during resting. To predict the risk of SUDEP, the relationship between HRV parameters and SUDEP risks was evaluated using the Risk Assessment for Sudden Death in Epilepsy (SUDEP-7) Risk Inventory.<\/jats:p><jats:p>\n          Results\u2003No statistically significant difference was found in sympathetic skin response (SSR) latency and amplitudes between the patient and control groups. In comparing healthy control subjects with patients experiencing DRE, we observed significant decreases in SDRRHV and hyperventilation-induced RMSSD (RMSSDHV) values, specifically within HRVHV. Notably, a significant correlation emerged concerning the RMSSDHV values (p\u2009&lt;\u20090.01), when examining the correlation between the SUDEP-7 inventory and HRVHV parameters.<\/jats:p><jats:p>\n          Conclusion\u2003This correlation between RMSSDHV and the SUDEP-7 Risk Inventory in patients with DRE represents a novel and consequential finding, suggesting its potential as an indicator of SUDEP risk.<\/jats:p>","DOI":"10.1055\/s-0044-1791517","type":"journal-article","created":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T23:34:44Z","timestamp":1730676884000},"page":"001-007","source":"Crossref","is-referenced-by-count":0,"title":["Association of hyperventilation-induced heart rate variability and sudden unexpected death in epilepsy in drug-resistant epilepsy"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-5105","authenticated-orcid":false,"given":"Demet Ilhan","family":"Algin","sequence":"additional","affiliation":[{"name":"Eskisehir Osmangazi University Faculty of Medicine, Department of Neurology, Eskisehir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2149-392X","authenticated-orcid":false,"given":"Oguz","family":"Erdinc","sequence":"additional","affiliation":[{"name":"Eskisehir Osmangazi University Faculty of Medicine, Department of Neurology, Eskisehir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S1474-4422(16)30158-2","article-title":"Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention","volume":"15","author":"O Devinsky","year":"2016","journal-title":"Lancet 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