{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:17Z","timestamp":1787004917725,"version":"build-2736575974"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":274,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Japanese Grants-in-Aid for Scientific Research\/Japan Society for the Promotion of Science KAKENHI Grant","award":["19K18194"],"award-info":[{"award-number":["19K18194"]}]},{"name":"Japan Arteriosclerosis Prevention Fund Research Grant"},{"name":"Japan Heart Foundation Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aorta (Stamford)"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Aortic wall enhancement (AWE), evaluated with computed tomography angiography in Type B aortic dissection, is associated with aortic remodeling. This study aimed to evaluate the relationship between AWE and pathological findings of the aortic wall using an aortic wall sample from a Type A aortic dissection (TAD).<\/jats:p>\n                  <jats:p>Methods\u2003We examined patients with TAD treated between January 2012 and February 2023.<\/jats:p>\n                  <jats:p>Results\u2003Twelve cases were examined pathologically: five cases in the hyperacute phase, three in the acute phase, and four in the subacute phase. AWE thickness significantly differed as time progressed (0 vs. 1.7 vs. 2.8\u2009mm, p\u2009&lt;\u20090.001). A significant increase in granulation was observed in the acute and subacute phases (0 vs. 761 vs. 423\u2009\u00b5m, p\u2009&lt;\u20090.001). Furthermore, a fibrous complex of internal adventitia (FCIA) developed on the medial side of the adventitia over time since its onset and was found to be thickened (175 vs. 415 vs. 1,078\u2009\u00b5m, p\u2009&lt;\u20090.001). The thickness of the granulation tissue and FCIA, where there was abundant neovascularization, was consistent with the thickness of the AWE.<\/jats:p>\n                  <jats:p>Conclusion\u2003AWE was observed in TAD and increased as time progressed. FCIA and granulation tissue developed, and AWE reflected neovascularization at the adventitia.<\/jats:p>","DOI":"10.1055\/s-0044-1791669","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T19:03:52Z","timestamp":1735671832000},"page":"025-031","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between Neovascularization and Aortic Wall Enhancement in Type A Aortic Dissection"],"prefix":"10.1055","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-7016","authenticated-orcid":false,"given":"Eisaku","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, The Jikei University Kashiwa Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohki","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Toya","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, The Jikei University Kashiwa Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University Kashiwa Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyasu","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University Kashiwa Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University Kashiwa Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nei","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misayo","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miku","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Jikei University School of Medicine, Tokyo, 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