{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:39Z","timestamp":1740126879629,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":129,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smartphone-based fertility awareness methods with home-based urinary hormonal testing are gaining popularity for fertility tracking. In our university-affiliated family practice, we integrated a previously developed ovulation tracking application into a protocol for monitoring urinary sex hormones and cervical secretions. Serum progesterone was used to confirm the luteal phase, with levels \u2265 15.9\u2009nmol\/L ensuring confirmation. Data from 110 women seen for infertility treatment (n\u2009=\u200995) or family planning advice (n\u2009=\u200915) and using our ovulation prediction protocol showed that most opted for a combination of cervical mucus and luteinizing hormone testing (n\u2009=\u200986). Among those using it for family planning, the median usage among women spanned 56 cycles, and 13 cycles per woman required progesterone testing for confirmation. Thirteen patients are still using the method without unintended pregnancies. No unintended pregnancies occurred. Confidence in tests based on serum progesterone was high (93%). For infertility, the method helped in the identification of anovulation, evaluating treatment response, and in diagnosing subfertility causes. This proof-of-concept retrospective descriptive case series suggests the potential for smartphone-based monitoring in fertility management, urging further studies for application enhancements and prospective validation.<\/jats:p>","DOI":"10.1055\/s-0044-1791702","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T23:46:00Z","timestamp":1728431160000},"page":"090-099","source":"Crossref","is-referenced-by-count":0,"title":["Helping Patients to Predict and Confirm Ovulation with the Use of Combined Urinary Hormonal and Smartphone Technology: A Proof-of-Concept Retrospective Descriptive Case Series"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-3236","authenticated-orcid":false,"given":"Rene","family":"Leiva","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Bruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Ecochard","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Universite de Lyon, Lyon, France"},{"name":"Laboratoire de Biometrie et Biologie Evolutive, Centre National de la Recherche Scientifique, Equipe Biostatistique-Sante, Universite Lyon 1, Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/humrep\/deaa176","article-title":"Fecundability in relation to use of mobile computing apps to track the menstrual cycle","volume":"35","author":"J B Stanford","year":"2020","journal-title":"Hum Reprod"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3122\/jabfm.2016.04.160022","article-title":"The performance of fertility awareness-based method apps marketed to avoid pregnancy","volume":"29","author":"M Duane","year":"2016","journal-title":"J Am Board Fam Med"},{"issue":"04","key":"ref3","first-page":"265","article-title":"Smartphone apps for fertility tracking: How do they measure up?","volume":"23","author":"S Johnson","year":"2018","journal-title":"Journal of Contraception and Reproductive Health Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fpubh.2018.00098","article-title":"Plausibility of menstrual cycle apps claiming to support conception","volume":"6","author":"A Freis","year":"2018","journal-title":"Front Public Health"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/13625187.2021.1874336","article-title":"Women's perspectives on smartphone apps for fertility tracking and predicting conception: a mixed methods study","volume":"26","author":"D L Blair","year":"2021","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/13625187.2021.1871599","article-title":"The performance of a fertility tracking device","volume":"26","author":"N van de Roemer","year":"2021","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/13625187.2016.1154143","article-title":"Fertility awareness-based mobile application for contraception","volume":"21","author":"E Berglund Scherwitzl","year":"2016","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/13625187.2020.1867844","article-title":"Natural cycles app: contraceptive outcomes and demographic analysis of UK users","volume":"26","author":"J T Pearson","year":"2021","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/0024363919885551","article-title":"The identification of postovulation infertility with the measurement of early luteal phase (peak day +3) progesterone production","volume":"87","author":"T W Hilgers","year":"2020","journal-title":"Linacre Q"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.steroids.2015.06.013","article-title":"Random serum progesterone threshold to confirm ovulation","volume":"101","author":"R Leiva","year":"2015","journal-title":"Steroids"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1370\/afm.2653","article-title":"Combination of home-based hormonal and mobile technology for virtual monitoring of menstrual cycles","volume":"19","author":"R Leiva","year":"2021","journal-title":"Ann Fam Med"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0015-0282(16)45671-2","article-title":"A prospective multicentre trial of the ovulation method of natural family planning. I. The teaching phase","volume":"36","year":"1981","journal-title":"Fertil Steril"},{"issue":"06","key":"ref13","first-page":"1285","article-title":"Vulvar mucus observations and the probability of pregnancy","volume":"101","author":"J B Stanford","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3122\/jabfm.2014.03.130255","article-title":"Use of ovulation predictor kits as adjuncts when using fertility awareness methods (FAMs): a pilot study","volume":"27","author":"R Leiva","year":"2014","journal-title":"J Am Board Fam Med"},{"issue":"09","key":"ref15","first-page":"CD011345","article-title":"Timed intercourse for couples trying to conceive","volume":"9","author":"T Gibbons","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.fertnstert.2021.08.038","article-title":"Fertility evaluation of infertile women: a committee opinion","volume":"116","author":"Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org","year":"2021","journal-title":"Fertil Steril"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.fertnstert.2021.02.010","article-title":"Diagnosis and treatment of luteal phase deficiency: a committee opinion","volume":"115","author":"Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility","year":"2021","journal-title":"Fertil Steril"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.fertnstert.2013.06.002","article-title":"Cervical mucus monitoring prevalence and associated fecundability in women trying to conceive","volume":"100","author":"E Evans-Hoeker","year":"2013","journal-title":"Fertil Steril"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1093\/humrep\/deu195","article-title":"The role of the cervix in fertility: is it time for a reappraisal?","volume":"29","author":"F Martyn","year":"2014","journal-title":"Hum Reprod"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"108964","DOI":"10.1016\/j.steroids.2022.108964","article-title":"Descriptive analysis of the relationship between progesterone and basal body temperature across the menstrual cycle","volume":"178","author":"R \u00c9cochard","year":"2022","journal-title":"Steroids"}],"container-title":["Seminars in Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1791702.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T01:31:09Z","timestamp":1732239069000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1791702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":20,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,11,21]]},"published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1791702","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1526-8004","1526-4564"],"issn-type":[{"type":"print","value":"1526-8004"},{"type":"electronic","value":"1526-4564"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}