{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:34:39Z","timestamp":1737610479312,"version":"3.33.0"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Few studies have investigated the relationship between cytokines and dizziness in elderly individuals.<\/jats:p><jats:p>\n          Objective\u2003To assess the levels of inflammatory biomarkers and their relationship with quality of life (QoL) among elderly individuals with dizziness.<\/jats:p><jats:p>\n          Methods\u2003We conducted a cross-sectional study with 103 participants (90 women and 13 men) who were assessed through the Visual Analogue Scale (VAS) and the Dizziness Handicap Inventory (DHI). The plasma levels of cytokines were measured through the cytometric bead array (CBA) method. Cross-tabulations with the Chi-squared test were used to verify sample homogeneity, and parametric tests were used to analyze the data.<\/jats:p><jats:p>\n          Results\u2003Out of the total sample of 103 individuals, dizziness was reported by 40 women and 5 men. A difference between the groups with and without dizziness was observed regarding the levels of interleukin 4 (IL-4; p\u2009=\u20090.011): the group without dizziness presented a higher mean level (2.1\u2009\u00b1\u20092.8 pg\/mL) when compared to the group that presented dizziness (1.0\u2009\u00b1\u20091.7 pg\/mL). Another difference was found between the DHI classifications and the plasma levels of tumor necrosis factor alpha (TNF-\u03b1;) p\u2009=\u20090.015): the groups without any losses in QoL presented lower TNF-\u03b1 levels (1.4 pg\/mL) compared to the group that presented moderate QoL loss (6.3 pg\/mL).<\/jats:p><jats:p>\n          Conclusion\u2003Dizziness affects the functional, physical and emotional dimensions of QoL and plays a role in the decrease in the levels of IL-4 and in the presence of fullness and tinnitus. Higher VAS scores are related to dizziness in the elderly. Moreover, the increased levels of TNF-\u03b1 were associated to light-to-moderate losses in QoL among elderly patients with dizziness.<\/jats:p>","DOI":"10.1055\/s-0044-1791731","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T23:57:14Z","timestamp":1737590234000},"page":"001-007","source":"Crossref","is-referenced-by-count":0,"title":["Plasmatic Levels of Cytokines and Quality of Life among Elderly Individuals with Dizziness"],"prefix":"10.1055","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2466-9908","authenticated-orcid":false,"given":"Gislaine da Silva","family":"Moreira","sequence":"additional","affiliation":[{"name":"Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)\/Universidade Pit\u00e1goras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-0468","authenticated-orcid":false,"given":"Luciana Lozza de Moraes","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"},{"name":"Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"},{"name":"Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-7218","authenticated-orcid":false,"given":"Daiane Soares de Almeida","family":"Ciquinato","sequence":"additional","affiliation":[{"name":"Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"},{"name":"Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-9128","authenticated-orcid":false,"given":"Braulio Henrique Magnani","family":"Branco","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"},{"name":"Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"},{"name":"Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maring\u00e1, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-4606","authenticated-orcid":false,"given":"Regina C\u00e9lia","family":"Poli-Frederico","sequence":"additional","affiliation":[{"name":"Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)\/Universidade 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