{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:27:14Z","timestamp":1787164034268,"version":"build-2736575974"},"reference-count":120,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aspiration represents the passage of oropharyngeal content to the lower respiratory tract. The interplay between the host and the aspirate proprieties determines the subsequent aspiration syndrome. A low pH, typical of gastric aspirate, favors chemical pneumonitis, whereas an increased bacterial inoculum causes aspiration pneumonia. About a quarter of patients with aspiration pneumonitis will develop a bacterial superinfection during the course of recovery. While antibiotic therapy is indicated for aspiration pneumonia, supportive care remains the cornerstone of treatment in aspiration pneumonitis. However, the overlapping clinical features of these syndromes lead to initiation of antimicrobial therapy in most cases of aspiration. Bronchoscopy can aid in clinical decision-making by direct airway visualization and also by providing access to a series of emerging biomarkers. Invasive microbiological studies increase diagnostic yield and enable a tailored antibiotic treatment. In conjunction with stewardship programs, invasive sampling and novel molecular diagnostics can decrease the amount of inappropriate antibiotic therapy. In the context of foreign body aspiration, bronchoscopy represents both diagnostic and treatment gold standard.<\/jats:p>","DOI":"10.1055\/s-0044-1791739","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T19:01:35Z","timestamp":1729796495000},"page":"650-658","source":"Crossref","is-referenced-by-count":4,"title":["Is There a Role for Bronchoscopy in Aspiration Pneumonia?"],"prefix":"10.1055","volume":"45","author":[{"given":"Andrei M.","family":"Darie","sequence":"additional","affiliation":[{"name":"Clinic of Respiratory Medicine, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Stolz","sequence":"additional","affiliation":[{"name":"Clinic of Respiratory Medicine, University of Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1586\/ers.13.24","article-title":"The role of the bacterial microbiome in lung disease","volume":"7","author":"R P Dickson","year":"2013","journal-title":"Expert Rev Respir Med"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"L1047","DOI":"10.1152\/ajplung.00279.2015","article-title":"Homeostasis and its disruption in the lung microbiome","volume":"309","author":"R P Dickson","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1714562","article-title":"Aspiration pneumonia","volume":"380","author":"L A Mandell","year":"2019","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0002-9378(16)39829-5","article-title":"The aspiration of stomach contents into the lungs during obstetric anesthesia","volume":"52","author":"C L Mendelson","year":"1946","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1513\/AnnalsATS.201502-089PS","article-title":"Historical perspectives of bronchoscopy. 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