{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:57:01Z","timestamp":1791608221799,"version":"4.3.4"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venous thromboembolism (VTE) after hospital discharge poses a serious health risk. Assessments of patient characteristics, prophylaxis, treatment, outcomes, and over time changes lack consistency. Data on 16,901 hospitalized patients in the Registro Informatizado Enfermedad TromboEmbolica registry (2003\u20132022) were analyzed to evaluate trends in baseline characteristics, prophylaxis, treatments, and 90-day outcomes among medical (6,218) and surgical (10,683) patient cohorts. Multivariable logistic regression was used to assess the risks of the composite of fatal pulmonary embolism (PE) or recurrent VTE and major bleeding. The proportion of patients who presented with PE increased among medical (from 54 to 72%) and surgical patients (from 55 to 58%). Prophylaxis use increased in medical patients (from 53 to 71%), while decreasing in surgical patients (from 67 to 58%). Notably, the 90-day composite of fatal PE or recurrent VTE decreased in medical (from 3.9 to 1.8%) and surgical patients (from 2.9 to 1.2%; p\u2009&lt;\u20090.001 for both). Conversely, major bleeding increased (3.1 to 4.5%) in medical patients (p\u2009=\u20090.008), with no change in surgical patients (from 2.5 to 2.4%). Risk-adjusted analysis showed a yearly decrease in the risk for the composite outcome (subhazard ratio [sHR]: 0.95; 95% confidence interval [CI]: 0.93\u20130.98) in medical and surgical patients and an increase in the risk for major bleeding in medical patients only (sHR: 1.04; 95% CI: 1.01\u20131.07). Results were consistent after excluding coronavirus disease 2019 patients. Over 20 years, the composite of fatal PE or recurrent VTE within 90 days had significantly decreased in VTE patients after hospitalization for medical or surgical care. Medical patients, however, exhibited an increase in major bleeding.<\/jats:p>","DOI":"10.1055\/s-0044-1791817","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T22:44:47Z","timestamp":1729205087000},"page":"301-311","source":"Crossref","is-referenced-by-count":2,"title":["Venous Thromboembolism after Hospital Discharge: Temporal Trends in Baseline Characteristics, Prevention, Treatment, and 90-day Outcomes"],"prefix":"10.1055","volume":"51","author":[{"given":"Benjamin","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Tzoran","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division and the Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut"},{"name":"Cardiovascular Research Foundation, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Sierrallana, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Poenou","sequence":"additional","affiliation":[{"name":"Department of M\u00e9decine et Th\u00e9rapeutique, H\u00f4pital Nord\u2014CHU St-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo","family":"Tirado-Miranda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Infanta Margarita, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General Universitario de Elda, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pag\u00e1n-Escribano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General Universitario Morales Meseguer, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Giorgi-Pierfranceschi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istituti Ospitalieri di Cremona, Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CIBER de Enfermedades Respiratorias, Madrid, Spain"},{"name":"Chair for the Study of Thromboembolic Disease, Faculty of Health Sciences, UCAM\u2014Universidad Cat\u00f3lica San Antonio de Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RIETE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(08)60202-0","article-title":"Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study","volume":"371","author":"A T Cohen","year":"2008","journal-title":"Lancet"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"J A Heit","year":"2015","journal-title":"Nat Rev Cardiol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/jth.15607","article-title":"An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta-analysis","volume":"20","author":"G Forgo","year":"2022","journal-title":"J Thromb Haemost"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"F Khan","year":"2021","journal-title":"Lancet"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/j.1538-7836.2010.04044.x","article-title":"A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score","volume":"8","author":"S Barbar","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1055\/s-0040-1710326","article-title":"Prevention of venous thromboembolism in hospitalized medically ill patients: a U.S. perspective","volume":"120","author":"A C Spyropoulos","year":"2020","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society 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