{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:40:10Z","timestamp":1732927210118,"version":"3.30.0"},"reference-count":73,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic considerations for aspiration pneumonia prioritize the risk of multidrug-resistant organisms. This involves integrating microbiological insights with each patient's unique risk profile, including the location at the time of aspiration, and whether it occurred in or out of the hospital. Our understanding of the microbiology of aspiration pneumonia has also evolved, leading to a reassessment of anaerobic bacteria as the primary pathogens. Emerging research shows a predominance of aerobic pathogens, in both community and hospital-acquired cases. This shift challenges the routine use of broad-spectrum antibiotics targeting anaerobes, which can contribute to antibiotic resistance and complications such as Clostridium difficile infections\u2014concerns that are especially relevant given the growing issue of antimicrobial resistance. Adopting a comprehensive, patient-specific approach that incorporates these insights can optimize antibiotic selection, improve treatment outcomes, and reduce the risk of resistance and adverse effects.<\/jats:p>","DOI":"10.1055\/s-0044-1791826","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T22:59:39Z","timestamp":1729897179000},"page":"701-708","source":"Crossref","is-referenced-by-count":0,"title":["Therapy of Aspiration: Out-of-Hospital and In-Hospital-Acquired"],"prefix":"10.1055","volume":"45","author":[{"given":"Di","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Niederman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and treatment of adults with community-acquired pneumonia. 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Hasegawa","year":"2019","journal-title":"J Comp Eff Res"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chest.2024.02.025","article-title":"Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: a retrospective cohort study","volume":"166","author":"A D Bai","year":"2024","journal-title":"Chest"},{"issue":"07","key":"ref51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jamainternmed.2024.0581","article-title":"Mortality of patients with sepsis administered piperacillin-tazobactam vs cefepime","volume":"184","author":"R Chanderraj","year":"2024","journal-title":"JAMA Intern Med"},{"issue":"07","key":"ref52","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3760\/cma.j.issn.0366-6999.20131635","article-title":"Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors","volume":"127","author":"T Sun","year":"2014","journal-title":"Chin Med J (Engl)"},{"issue":"02","key":"ref53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jiac.2019.08.005","article-title":"Cefepime vs. meropenem for moderate-to-severe pneumonia in patients at risk for aspiration: an open-label, randomized study","volume":"26","author":"I Oi","year":"2020","journal-title":"J Infect Chemother"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12890-020-01198-4","article-title":"Comparison of ceftriaxone plus macrolide and ampicillin\/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial","volume":"20","author":"N Hamao","year":"2020","journal-title":"BMC Pulm Med"},{"issue":"06","key":"ref55","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1378\/chest.08-0011","article-title":"Early microbiological response to linezolid 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