{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:15:47Z","timestamp":1747282547573,"version":"3.40.5"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003This study aimed to evaluate the non-neoplastic renal parenchyma in Wilms tumor (WT) and investigate its impact on nephron-sparing surgery (NSS).<\/jats:p><jats:p>\n          Materials and Methods\u2003The non-neoplastic renal parenchyma of WT patients was prospectively collected for pathological examination. The histology of non-neoplastic renal parenchyma was assessed from two perspectives: nephrogenic rests (NRs) and nephrons.<\/jats:p><jats:p>\n          Results\u2003A total of 46 non-neoplastic renal parenchyma specimens were collected from 42 WT patients. The surgeons assessed the median proportion of non-neoplastic renal parenchyma as 30%, whereas using ellipsoid volume, it was calculated to be 27%. The Youden index of surgeons' assessment peaked at a 15% proportion of non-neoplastic renal parenchyma. The bilateral WT (BWT) group and NSS group exhibited significant differences compared with the unilateral WT group and radical nephrectomy group, respectively, with the BWT group showing a tendency toward thickened basement membrane.<\/jats:p><jats:p>\n          Conclusion\u2003The presence of NRs and endogenous nephron alternations should be given due attention in WT. The probability of abnormalities is low when the proportion of non-neoplastic renal parenchyma exceeds 15%, providing pathological support for expanding the adaptation of NSS.<\/jats:p>","DOI":"10.1055\/s-0044-1791846","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T01:09:11Z","timestamp":1729300151000},"page":"187-194","source":"Crossref","is-referenced-by-count":0,"title":["Pathological Insights into Non-Neoplastic Renal Parenchyma in Wilms Tumor: Implications for Nephron-Sparing Surgery"],"prefix":"10.1055","volume":"35","author":[{"given":"Mingchuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Diagnostics Laboratory Group Co Ltd, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Organ Transplant Center, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juncheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Organ Transplant Center, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"},{"name":"Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"},{"name":"Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"},{"name":"Organ Transplant Center, Sun Yat-sen University First Affiliated Hospital, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"03","key":"ref1","first-page":"147","article-title":"Towards an understanding of Wilms' tumour","volume":"75","author":"K A Williamson","year":"1994","journal-title":"Int J Exp Pathol"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41585-018-0100-3","article-title":"The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol","volume":"15","author":"G M Vujani\u0107","year":"2018","journal-title":"Nat Rev Urol"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"e26547","DOI":"10.1002\/pbc.26547","article-title":"Nephrogenic rests in Wilms tumors treated with preoperative chemotherapy: The UK SIOP Wilms Tumor 2001 Trial experience","volume":"64","author":"G M Vujani\u0107","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"02","key":"ref4","first-page":"141","article-title":"Wilms' tumor and glomerular disease. 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