{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:59:51Z","timestamp":1773979191063,"version":"3.50.1"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The mechanical stimulation known as orthodontic mechanical force (OMF) causes biological reactions in orthodontic tooth movement (OTM). Heat shock protein-70 (HSP-70) needs pro-inflammatory cytokines to trigger bone resorption in OTM; nevertheless, heat shock protein-10 (HSP-10), a \u201cAlarmin\u201d cytokine, should control these pro-inflammatory cytokines to get the best alveolar bone remodeling (ABR). Moringa oleifera L. nanosuspension extract (MONE) has anti-inflammatory, antioxidant, and ABR-stimulating properties. The aim of the study was to examine in vivo HSP-10 and HSP-70 expressions under OMF following MONE application in Wistar rats (Rattus norvegicus).<\/jats:p><jats:p>\n          Material and Methods\u2003A total of 36 Wistar rats (R. norvegicus) were split up into eight groups: one for treatment (OMF + MONE) and one for control (OMF + MONE administration for days 1, 7, 14, and 21). By employing nickel\u2013titanium coil springs and using 10\u2009g of light force per millimeter to implant the orthodontic device, the OMF was completed. According to the day of observation, all of the samples were sacrificed. To perform an immunohistochemistry investigation, the premaxilla of the sample was isolated. Tukey's Honest Significant Different (HSD) test (p\u2009&lt;\u20090.05) was performed after an Analysis of Variance (ANOVA) analysis of the data.<\/jats:p><jats:p>\n          Results\u2003In both the OMF and MONE groups, HSP-70 peaked on day 14 and began to fall on day 21. HSP-10 peaked on day 21, but along with MONE, it also began to progressively decline on days 14 and 21, with significant differences (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003According to immunohistochemistry evidence, postadministration of MONE markedly elevated HSP-10 but lowered HSP-70 expression in the alveolar bone of Wistar rats under OMF.<\/jats:p>","DOI":"10.1055\/s-0044-1791937","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:21:42Z","timestamp":1736468502000},"page":"523-530","source":"Crossref","is-referenced-by-count":2,"title":["Moringa oleifera L. Nanosuspension Extract Administration Affects Heat Shock Protein-10 and -70 under Orthodontics Mechanical Force In Vivo"],"prefix":"10.1055","volume":"19","author":[{"given":"Ari","family":"Triwardhani","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alida","family":"Alida","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervina Restiwulan","family":"Winoto","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adya","family":"Pramusita","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurul Aisyah Rizki","family":"Putranti","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Satrio","family":"Ariadi","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okso Brillian","family":"Pribadi","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia Aisyiah","family":"Anwar","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alqomariyah Eka","family":"Purnamasari","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifqah Ananda","family":"Mappananrang","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putri Cahaya","family":"Situmorang","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-5051","authenticated-orcid":false,"given":"Wibi","family":"Riawan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengku Natasha Eleena binti Tengku Ahmad","family":"Noor","sequence":"additional","affiliation":[{"name":"Membership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5455-3387","authenticated-orcid":false,"given":"Albertus Putera","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Patera","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 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