{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:14:18Z","timestamp":1789625658300,"version":"build-2803163510"},"reference-count":10,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fever is a known complication in pediatric cancer patients when on chemotherapy for which prompt initiation of empiric antibiotics is the single most important life-saving intervention. Nearly two-thirds of all children are treated without identifying the source of fever. Molecular diagnostics can improve management of febrile episodes and reduce unnecessary antibiotic use. The purpose of our study was to evaluate the pathogenic etiology of febrile episodes and analyze their clinical characteristics.<\/jats:p>\n                  <jats:p>We conducted a prospective observational study at our tertiary care institution from January 2019 to March 2020, to identify the etiology of febrile episodes with or without neutropenia in pediatric cancer patients and to study their clinical outcomes.<\/jats:p>\n                  <jats:p>Forty febrile episodes were observed among 27 patients over a period of 15 months. The mean age group was 5 years. In 28 febrile episodes without a focus (70%), a respiratory organism (virus, bacteria, or coinfection) was detected. Rhinovirus was the most common single respiratory isolate (47.36%), followed by Streptococcus pneumoniae (21.05%) and six episodes had multiple viral isolates (21.42%). There was no prolonged hospitalization, need for intensive care unit or oxygen requirement, or mortality. The most common antibiotic used in empiric management was piperacillin\u2013tazobactam. Aminoglycosides were added when there was a clinical suspicion of resistant organism.<\/jats:p>\n                  <jats:p>Around 70% of febrile episodes without a focus or documented infection in cancer children had a respiratory pathogen identified in nasopharyngeal swab. Molecular diagnostics greatly enhances diagnostic sensitivity and thereby individualizes the management of febrile illness in these children.<\/jats:p>","DOI":"10.1055\/s-0044-1791970","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T20:32:21Z","timestamp":1730233941000},"page":"574-579","source":"Crossref","is-referenced-by-count":2,"title":["Frequency and Clinical Outcomes of Respiratory Infections in Children with Cancer Presenting with Febrile Illness"],"prefix":"10.25259","volume":"14","author":[{"given":"Arathi","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato-oncology, Kanchi Kamakoti CHILDS Trust Hospital (KKCTH), Nungambakkam, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya Manur","family":"Sekar","sequence":"additional","affiliation":[{"name":"The CHILDS Trust Medical Research Foundation (CTMRF)- KKCTH, Nungambakkam, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Chandy","sequence":"additional","affiliation":[{"name":"The CHILDS Trust Medical Research Foundation (CTMRF)- KKCTH, Nungambakkam, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanian","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"issue":"01","key":"ref1","first-page":"e33314","article-title":"Role of polymerase chain reaction-based diagnosis of respiratory viruses in febrile neutropenic patients","volume":"15","author":"J Madhuravasal Krishnan","year":"2023","journal-title":"Cureus"},{"issue":"18","key":"ref2","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1200\/JCO.2016.71.7017","article-title":"Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update","volume":"35","author":"T Lehrnbecher","year":"2017","journal-title":"J Clin Oncol"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/INF.0b013e31825c4b7e","article-title":"Frequency and clinical outcome of respiratory viral infections and mixed viral-bacterial infections in children with cancer, fever and neutropenia","volume":"31","author":"J P Torres","year":"2012","journal-title":"Pediatr Infect Dis J"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/cncr.29833","article-title":"Acute respiratory infections in children and adolescents with acute lymphoblastic leukemia","volume":"122","author":"H Hakim","year":"2016","journal-title":"Cancer"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/jmv.25432","article-title":"Prevalence and characteristics of acute respiratory virus infections in pediatric cancer patients","volume":"91","author":"N Soudani","year":"2019","journal-title":"J Med Virol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/diseases8030032","article-title":"Pulmonary infectious complications in children with hematologic malignancies and chemotherapy-induced neutropenia","volume":"8","author":"A Voulgaridou","year":"2020","journal-title":"Diseases"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jcv.2011.12.020","article-title":"Comparison of two broadly multiplexed PCR systems for viral detection in clinical respiratory tract specimens from immunocompromised children","volume":"53","author":"R T Hayden","year":"2012","journal-title":"J Clin Virol"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/INF.0000000000001209","article-title":"Respiratory viral infections and coinfections in children with cancer, fever and neutropenia: clinical outcome of infections caused by different respiratory viruses","volume":"35","author":"J P Torres","year":"2016","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1177\/0009922812456736","article-title":"Nasopharyngeal detection of respiratory viruses in febrile neutropenic children","volume":"51","author":"M Suryadevara","year":"2012","journal-title":"Clin Pediatr (Phila)"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1097\/INF.0b013e31827bd619","article-title":"Prospective detection of respiratory pathogens in symptomatic children with cancer","volume":"32","author":"A Srinivasan","year":"2013","journal-title":"Pediatr Infect Dis J"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1791970.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:13:14Z","timestamp":1781176394000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/frequency-and-clinical-outcomes-of-respiratory-infections-in-children-with-cancer-presenting-with-febrile-illness\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":10,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,12,23]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1791970","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]}}}