{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:39:47Z","timestamp":1785152387383,"version":"3.55.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue is the main urban arbovirus in the Americas. The disease manifests in a varied spectrum: from asymptomatic cases to those with neurological involvement, which is considered a severe form of the disease. Its annual reemergence represents a serious public health problem. The rise in the number of cases causes an increase in the number of patients with neurological manifestations of the disease, which can range from headaches to more serious conditions such as encephalitis and Guillain-Barr\u00e9 syndrome, with high potential of death or sequelae. Dengue prevention and control strategies should also be a concern for neurologists. The aim of the present study is to carry out a narrative review of the current methods to prevent dengue fever and its severe forms, such as cases with neurological complications. The main control measures include vaccination, which is still carried out on a small scale, vector control, and individual protection. The CYD-TDV\/Dengvaxia and TAK-003\/DENVax vaccines, licensed for use by the Brazilian National Health Regulatory Agency (Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria, ANVISA, in Portuguese), show efficacy against hospitalizations of 72.7% (95% confidence interval [95%CI]: 62.3\u201380.3%) and of 90.4% (95%CI: 82.6\u201394.7%) respectively. The TV003\/TV005 vaccine, which is being studied by Intituto Butantan in Brazil, shows promising results, with an efficacy of 79.6% for symptomatic dengue. Vector control is based on biotechnological and behavioral measures, as well as on the improvement of basic sanitation conditions. The main individual protection measure is the use of topical repellents (icaridin). All of these actions represent important tools for the prevention of dengue fever and its neurological complications.<\/jats:p>","DOI":"10.1055\/s-0044-1792091","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:55:56Z","timestamp":1733273756000},"page":"001-006","source":"Crossref","is-referenced-by-count":4,"title":["Dengue and severe dengue with neurological complications: a challenge for prevention and control"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4524-1232","authenticated-orcid":false,"given":"Emanuelle de Oliveira","family":"Francelino","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-9142","authenticated-orcid":false,"given":"Marzia","family":"Puccioni-Sohler","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro RJ, Brazil."},{"name":"Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11910-022-01213-7","article-title":"Neurological Complications of Dengue Fever","volume":"22","author":"S Trivedi","year":"2022","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-virology-031413-085513","article-title":"Role of the Vector in Arbovirus Transmission","volume":"1","author":"M J Conway","year":"2014","journal-title":"Annu Rev Virol"},{"key":"ref5","first-page":"44","volume-title":"Manual de Vigil\u00e2ncia Sentinela de Doen\u00e7as Neuroinvasivas por Arbov\u00edrus. 1st ed","year":"2017"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jns.2007.09.040","article-title":"Involvement of the central nervous system in patients with dengue virus infection","volume":"267","author":"R B Domingues","year":"2008","journal-title":"J Neurol Sci"},{"issue":"06","key":"ref7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1212\/CPJ.0000000000000776","article-title":"Dengue and chikungunya infection in neurologic disorders from endemic areas in Brazil","volume":"10","author":"C DS Mello","year":"2020","journal-title":"Neurol Clin Pract"},{"issue":"12","key":"ref8","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1055\/s-0043-1777104","article-title":"Review of dengue, zika and chikungunya infections in nervous system in endemic areas","volume":"81","author":"M Puccioni-Sohler","year":"2023","journal-title":"Arq Neuropsiquiatr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1590\/s0004-282","article-title":"Oligosymptomatic dengue infection: a potential cause of Guillain Barr\u00e9 syndrome","volume":"66","author":"C N Soares","year":"2008","journal-title":"Arq Neuropsiquiatr"},{"issue":"01","key":"ref10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13020-024-00893-2","article-title":"Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome","volume":"19","author":"H Huang","year":"2024","journal-title":"Chin Med"},{"issue":"02","key":"ref11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40506-023-00263-w","article-title":"Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines","volume":"15","author":"M Palanichamy Kala","year":"2023","journal-title":"Curr Treat Options Infect Dis"},{"issue":"03","key":"ref12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s40259-022-00531-z","article-title":"Dengue Vaccines: An Update","volume":"36","author":"J M Torres-Flores","year":"2022","journal-title":"BioDrugs"},{"issue":"13","key":"ref13","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","volume":"373","author":"S R Hadinegoro","year":"2015","journal-title":"N Engl J Med"},{"issue":"05","key":"ref15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1056\/NEJMoa2301790","article-title":"Live, Attenuated, Tetravalent Butantan-Dengue Vaccine in Children and Adults","volume":"390","author":"E G Kall\u00e1s","year":"2024","journal-title":"N Engl J Med"},{"issue":"07","key":"ref17","doi-asserted-by":"publisher","first-page":"e0007420","DOI":"10.1371\/journal.pntd.0007420","article-title":"Environmental methods for dengue vector control - 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