{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:48Z","timestamp":1740142428667,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Carpal tunnel syndrome (CTS) has already been described as a possible form of neural leprosy presentation. However, the median nerve can be involved in this neuropathy in proximal segments and, sometimes, with an asymmetric impairment of the digital branches.<\/jats:p><jats:p>\n          Objective\u2003To detail the pattern of median nerve impairment through nerve conduction study (NCS) and ultrasound evaluation.<\/jats:p><jats:p>\n          Methods\u2003This cross-sectional study comprises 15 primary neural leprosy (PNL) patients and 14 patients with CTS who underwent peripheral nerve ultrasonography and NCS evaluation.<\/jats:p><jats:p>\n          Results\u2003From the total, 92.8% of patients with CTS and 80% with PNL had bilateral impairment of the median nerve, with 27 nerves in each group. Considering the cross-sectional area (CSA) of the tunnel (Mt) segment, 63% of the nerves in the CTS and 74.1% in the PNL groups were found to be thickened, with an average CSA of 13.4\u2009\u00b1\u20094.4 and 12.4\u2009\u00b1\u20094.6, respectively (p\u2009=\u20090.18). The CSA of the proximal tunnel (Mpt) segment showed thickening in only 3.7% in the CTS group and 96.3% in the PNL (p\u2009&lt;\u20090.0001), with an average of 6.6\u2009\u00b1\u20091.3 and 17.0\u2009\u00b1\u20096.7, respectively (p\u2009&lt;\u20090.001). Finally, 88.9% of the nerves in the PNL group and only 7.4% in the CSA (p\u2009&lt;\u20090.0001) showed a reduction in conduction velocity in the distal forearm, with an average of 41.0\u2009\u00b1\u20096.3 and 53.2\u2009\u00b1\u20095.2, respectively (p\u2009&lt;\u20090.0001).<\/jats:p><jats:p>\n          Conclusion\u2003The presence of neural thickening and demyelinating impairment in the segments proximal to the carpal tunnel favors the diagnosis of leprosy.<\/jats:p>","DOI":"10.1055\/s-0044-1792092","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T01:08:53Z","timestamp":1733879333000},"page":"001-006","source":"Crossref","is-referenced-by-count":2,"title":["Median nerve impairment in leprosy: how does it differ from the classic carpal tunnel syndrome?"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8992-0339","authenticated-orcid":false,"given":"Pedro Henrique Sirotheau Corr\u00eaa","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."},{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2710-3912","authenticated-orcid":false,"given":"Fernanda de Oliveira","family":"Cirino","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."},{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-9765","authenticated-orcid":false,"given":"Leonardo Peixoto","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6284-9358","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Moreira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-6605","authenticated-orcid":false,"given":"Andrea De Martino","family":"Luppi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."},{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-7158","authenticated-orcid":false,"given":"Douglas Eul\u00e1lio","family":"Antunes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-5745","authenticated-orcid":false,"given":"Raquel Campos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-2749","authenticated-orcid":false,"given":"Wilson Marques","family":"Junior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, Departamento de Neurologia, Divis\u00e3o de Dist\u00farbios Neuromusculares, Ribeir\u00e3o Preto SP, Brazil."},{"name":"Instituto Nacional de Ci\u00eancias e Tecnologia (INCT) em Medicins Trsnslacional, Ribeir\u00e3o Preto SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-3223","authenticated-orcid":false,"given":"Isabela Maria Bernardes","family":"Goulart","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia Nacional em Hansen\u00edase e Dermatologia Sanit\u00e1ria, Uberl\u00e2ndia MG, Brazil."},{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Uberl\u00e2ndia MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-9987","authenticated-orcid":false,"given":"Diogo Fernandes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Faculdade de Medicina, Hospital das Cl\u00ednicas, Centro de Refer\u00eancia 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