{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:20Z","timestamp":1788412700840,"version":"build-2803163510"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Avaliar os efeitos da toxina botul\u00ednica (BTX-A) sobre o t\u00f4nus muscular e mobilidade articular de crian\u00e7as com s\u00edndrome cong\u00eanita do Zika (SCZ).<\/jats:p><jats:p>\n          M\u00e9todos\u2003Trata-se de uma s\u00e9rie de casos longitudinal realizada em um Centro de Apoio a Crian\u00e7a com Microcefalia, localizado no nordeste do Brasil. A coleta de dados foi realizada a partir dos prontu\u00e1rios dessa institui\u00e7\u00e3o, com o registro de informa\u00e7\u00f5es sobre o t\u00f4nus muscular e a mobilidade articular passiva, mensuradas pelo menos 3 meses antes e 4 semanas ap\u00f3s a aplica\u00e7\u00e3o da BTX-A.<\/jats:p><jats:p>\n          Resultados\u2003Foram avaliadas 13 crian\u00e7as (9 meninos) com idade m\u00e9dia de 77\u2009\u00b1\u20097,1 meses. Ap\u00f3s a aplica\u00e7\u00e3o da BTX-A, foi observada redu\u00e7\u00e3o bilateral do n\u00edvel de hipert\u00f4nia nos m\u00fasculos flexores do cotovelo (p\u2009&lt;\u20090,01) e adutores de quadril (p\u2009&lt;\u20090,05) bilateralmente.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003Nenhuma mudan\u00e7a foi observada na mobilidade articular e nenhum efeito adverso foi relatado pelos cuidadores ap\u00f3s a aplica\u00e7\u00e3o. O uso da BTX-A \u00e9 capaz de promover a redu\u00e7\u00e3o do n\u00edvel de hipertonia de crian\u00e7as com SCZ, sem impactar a mobilidade articular.<\/jats:p>","DOI":"10.1055\/s-0044-1792114","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T23:30:21Z","timestamp":1734823821000},"page":"e936-e943","source":"Crossref","is-referenced-by-count":1,"title":["Efeitos da toxina botul\u00ednica sobre o t\u00f4nus muscular e a mobilidade articular de crian\u00e7as com s\u00edndrome cong\u00eanita do Zika \u2013 Uma s\u00e9rie de casos"],"prefix":"10.1055","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3880-5584","authenticated-orcid":false,"given":"Patr\u00edcia Juliana da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande, PB, 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