{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:48:16Z","timestamp":1749631696351,"version":"3.38.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pigmented villonodular synovitis (PVNS) is a rare neoplastic proliferation of large joints, including the knee, with both localized PVNS (LPVNS) and diffuse PVNS (DPVNS) types. DPVNS is known to recur at a higher rate following resection; however, there is little evidence comparing patient-reported outcomes (PROs) between the two types. The purpose of this study was to compare PROs between patients with LPVNS and DPVNS involving the knee 2 years after surgical resection. We hypothesized that DPVNS would have worse 2-year PROs than LPVNS.<\/jats:p><jats:p>Sixteen patients who underwent arthroscopic resection of pathology-confirmed PVNS involving the knee were enrolled in a prospective registry. Several PROs, including six Patient-Reported Outcomes Measurement Information System (PROMIS) domains and the International Knee Documentation Committee (IKDC) Subjective Knee Form, were assessed at baseline and at 2 years postoperatively. Mean scores between LPVNS and DPVNS groups were compared using a Wilcoxon exact test, while categorical variables were compared using a Fisher's exact test.<\/jats:p><jats:p>Eleven patients (seven LPVNS and four DPVNS) completed both the baseline and 2-year PRO surveys. There were no significant differences in the demographic variables between groups, including age, body mass index, or prior surgical history (p\u2009&lt;\u20090.05). There was a trend toward higher mean PRO scores in the DPVNS group at 2 years postoperatively in all measures, despite lower reported baseline levels of activity as measured by Marx Activity Rating Scale (26.3 vs. 76.7, p\u2009=\u20090.02). The DPVNS group also trended toward more improvement in PROMIS Physical Function (9.7 vs. \u22122.7), PROMIS Pain Interference (\u22129.0 vs. \u22122.5), PROMIS Anxiety (\u22125.4 vs. \u22124.4), and IKDC (26.7 vs. 18.9). However, these differences did not reach statistical significance (p\u2009&lt;\u20090.05). There were two recurrences in the DPVNS group and none in the LPVNS group.<\/jats:p><jats:p>Patients with knee DPVNS do not report worse outcomes 2 years after arthroscopic resection compared with LPVNS patients.<\/jats:p>","DOI":"10.1055\/s-0044-1793939","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:15:51Z","timestamp":1732839351000},"page":"180-187","source":"Crossref","is-referenced-by-count":1,"title":["Patient-Reported Outcomes after Surgery for Pigmented Villonodular Synovitis in the Knee: A Cohort Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Ryan J.","family":"Lashgari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9696-1908","authenticated-orcid":false,"given":"Dominic J.","family":"Ventimiglia","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah E.","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-7427","authenticated-orcid":false,"given":"Matthew P.","family":"Kolevar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-9781","authenticated-orcid":false,"given":"Natalie L.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean J.","family":"Meredith","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-4294","authenticated-orcid":false,"suffix":"III","given":"R. Frank","family":"Henn","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5435\/00124635-200606000-00007","article-title":"Pigmented villonodular synovitis","volume":"14","author":"W K Tyler","year":"2006","journal-title":"J Am Acad Orthop Surg"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2217\/fon.13.124","article-title":"Pigmented villonodular synovitis: current concepts about diagnosis and management","volume":"9","author":"F GM Verspoor","year":"2013","journal-title":"Future Oncol"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.2106\/JBJS.RVW.15.00086","article-title":"Pigmented villonodular synovitis: a comprehensive review and proposed treatment algorithm","volume":"4","author":"S R Stephan","year":"2016","journal-title":"JBJS Rev"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1302\/0301-620X.97B4.34907","article-title":"The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis","volume":"97-B","author":"B Mollon","year":"2015","journal-title":"Bone Joint J"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"e19856","DOI":"10.1097\/MD.0000000000019856","article-title":"Recurrence of pigmented villonodular synovitis of the knee: a case report with review of literature on the risk factors causing recurrence","volume":"99","author":"Y Fang","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s11999-012-2589-8","article-title":"Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates?","volume":"471","author":"M W Colman","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/rheumatology\/keu230","article-title":"Long-term follow-up results of primary and recurrent pigmented villonodular synovitis","volume":"53","author":"F GM Verspoor","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.2196\/ijmr.9325","article-title":"The patient perspective on the impact of tenosynovial giant cell tumors on daily living: crowdsourcing study on physical function and quality of life","volume":"7","author":"M J Mastboom","year":"2018","journal-title":"Interact J Med Res"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1470-2045(19)30100-7","article-title":"Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study","volume":"20","author":"M JL Mastboom","year":"2019","journal-title":"Lancet Oncol"},{"issue":"07","key":"ref10","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/CORR.0000000000002934","article-title":"What are the recurrence rates, complications, and functional outcomes after multiportal arthroscopic synovectomy for patients with knee diffuse-type tenosynovial giant-cell tumors?","volume":"482","author":"L Yao","year":"2024","journal-title":"Clin Orthop Relat Res"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-0038-1646929","article-title":"Arthroscopic treatment of diffuse pigmented villonodular synovitis of the knee: complete synovectomy and septum removal-midterm results","volume":"32","author":"S Keyhani","year":"2019","journal-title":"J Knee Surg"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jcot.2017.04.003","article-title":"The Maryland Orthopaedic Registry (MOR): design and baseline characteristics of a prospective registry","volume":"8","author":"R F Henn III","year":"2017","journal-title":"J Clin Orthop Trauma"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/01.mlr.0000254567.79743.e2","article-title":"Evaluation of item candidates: the PROMIS qualitative item review","volume":"45","author":"D A DeWalt","year":"2007","journal-title":"Med Care"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/0363546505280214","article-title":"The International Knee Documentation Committee Subjective Knee Evaluation Form: normative data","volume":"34","author":"A F Anderson","year":"2006","journal-title":"Am J Sports 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Visual analog scale versus numeric pain scale: what is the difference?","volume":"4","author":"C Johnson","year":"2005","journal-title":"J Chiropr Med"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1007\/s11999-013-3013-8","article-title":"Measuring expectations in orthopaedic surgery: a systematic review","volume":"471","author":"M G Zywiel","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1941738115576121","article-title":"Reference values for the Marx Activity Rating Scale in a young athletic population: history of knee ligament injury is associated with higher scores","volume":"7","author":"K L Cameron","year":"2015","journal-title":"Sports Health"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/03635465010290021601","article-title":"Development and evaluation of an activity rating scale for disorders of the knee","volume":"29","author":"R G Marx","year":"2001","journal-title":"Am J Sports Med"},{"key":"ref21","first-page":"S133","article-title":"Validation of a new post surgical quality of life tool: the Surgical Satisfaction Questionnaire (SSQ-8)","volume":"20","author":"R Haff","year":"2009","journal-title":"Int Urogynecol J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"P A Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"P A Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"09","key":"ref24","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.arthro.2007.03.012","article-title":"Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee","volume":"23","author":"J S Dines","year":"2007","journal-title":"Arthroscopy"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s00167-011-1747-y","article-title":"Arthroscopic treatment of localized pigmented villonodular synovitis of the knee","volume":"20","author":"P Loriaut","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00264-016-3208-1","article-title":"Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients","volume":"40","author":"L van der Heijden","year":"2016","journal-title":"Int Orthop"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1177\/0363546508330149","article-title":"Lysholm score and Tegner activity level in individuals with normal knees","volume":"37","author":"K K Briggs","year":"2009","journal-title":"Am J Sports Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2474-7-38","article-title":"Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS)","volume":"7","author":"P T Paradowski","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"issue":"06","key":"ref29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.semarthrit.2010.07.005","article-title":"Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature","volume":"40","author":"S Ottaviani","year":"2011","journal-title":"Semin Arthritis Rheum"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0044-1793939.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T23:31:13Z","timestamp":1740785473000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0044-1793939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":28,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,2,28]]},"published-print":{"date-parts":[[2025,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0044-1793939","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"type":"print","value":"1538-8506"},{"type":"electronic","value":"1938-2480"}],"subject":[],"published":{"date-parts":[[2024,11,28]]}}}