{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:34:16Z","timestamp":1791513256841,"version":"4.3.4"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Introduction\u2003At high altitudes, hypobaric hypoxia leads to central apneas in both healthy adults and patients with obstructive sleep apnea. This condition correlates with intermittent desaturation and disruption of sleep.<\/jats:p><jats:p>\n               Materials and Methods\u2003The clinical case of a patient evaluated during a sleep medicine outpatient consultation at the Fundaci\u00f3n Neumol\u00f3gica Colombiana (Bogot\u00e1, Colombia, 2,600 masl) is reported.<\/jats:p><jats:p>\n               Case Study\u2003We present a 64-year-old male patient living in a high-altitude city, who was an aircrew member and was on continuous positive airway pressure (CPAP) therapy for severe obstructive sleep apnea (OSA). The patient had symptoms and central apneas only when he slept at high altitudes. Other causes of central apnea were ruled out, and these events were corrected with the administration of supplemental oxygen. Altitude-associated central apnea is a common disorder that can occur at altitudes higher than 1,600 m above sea level. Currently, the first-line treatments are acetazolamide and oxygen supplementation.<\/jats:p><jats:p>\n               Conclusions\u2003Changes in altitude should be considered in patients with OSA in PAP therapy, as it can occur in many occupations and in recreational travels.<\/jats:p>","DOI":"10.1055\/s-0044-1795145","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T18:56:31Z","timestamp":1741373791000},"page":"e241-e244","source":"Crossref","is-referenced-by-count":1,"title":["Altitude-Associated Central Apnea in Continuous Positive Airway Pressure Therapy"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-5585","authenticated-orcid":false,"given":"Gustavo Adolfo","family":"Gaitan Quintero","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogota, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-3600","authenticated-orcid":false,"given":"Leidy Paola","family":"Prada Romero","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogota, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3228-3460","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogota, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-0539","authenticated-orcid":false,"given":"Mar\u00eda Ang\u00e9lica","family":"Bazurto-Zapata","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogota, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s13665-019-0221-z","article-title":"Central sleep apnea: A brief review","volume":"8","author":"M S Badr","year":"2019","journal-title":"Curr Pulmonol Rep"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"1600959","DOI":"10.1183\/13993003.00959-2016","article-title":"Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep","volume":"49","author":"W Randerath","year":"2017","journal-title":"Eur Respir J"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/ham.2015.0016","article-title":"Patients with Obstructive Sleep Apnea at Altitude","volume":"16","author":"K E Bloch","year":"2015","journal-title":"High Alt Med 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Liu","year":"2017","journal-title":"Ther Adv Respir Dis"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.chest.2020.06.078","article-title":"Acetazolamide for OSA and central sleep apnea: A comprehensive systematic review and meta-analysis","volume":"158","author":"C N Schmickl","year":"2020","journal-title":"Chest"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.5664\/jcsm.1462","article-title":"The effects of altitude associated central apnea on the diagnosis and treatment of obstructive sleep apnea: comparative data from three different altitude locations in the mountain west","volume":"7","author":"J F Pagel","year":"2011","journal-title":"J Clin Sleep Med"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.sleep.2014.09.022","article-title":"Prevalence of central sleep apnea during continous positive airway pressure (CPAP) titration in subjects with obstructive sleep apnea syndrome at an altitude of 2640\u2009m","volume":"16","author":"M A Bazurto Zapata","year":"2015","journal-title":"Sleep Med"}],"container-title":["Sleep 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