{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:09:20Z","timestamp":1789495760901,"version":"build-2803163510"},"reference-count":14,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article studies the clinical outcome of patients with multiple myeloma who have renal failure at presentation.<\/jats:p>\n                  <jats:p>Patients with multiple myeloma presenting with serum creatinine of more than or equal to 2\u2009mg\/dL from outpatient department at Sri Ram Cancer Centre, Mahatma Gandhi Medical College &amp; Hospital, Jaipur, Rajasthan, India, were screened for baseline serum creatinine and estimated glomerular filtration rate (eGFR). Assessment was done at completion of 6 months from diagnosis\u2014patients' clinical condition, renal response (serum creatinine and eGFR), and disease response as per the International Myeloma Working Group criteria.<\/jats:p>\n                  <jats:p>Final response assessment was done at a follow-up of 6 months. Half of the patients achieved a renal complete response; the highest being in the lenalidomide group (83.3%). Patients with eGFR\u2009&lt;\u200915\u2009mL\/min\/m2 at presentation fared poorly versus those with eGFR\u2009&gt;\u200915\u2009mL\/min\/m2. Patients who were dialysis-dependent at baseline had poorer renal responses as compared with those who were dialysis-independent. Out of six patients who were initially dialysis-dependent, four (66.6%) became dialysis-independent after treatment.<\/jats:p>","DOI":"10.1055\/s-0044-1801287","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T19:15:59Z","timestamp":1736536559000},"page":"632-635","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcomes of Patients with Multiple Myeloma Presenting with Renal Failure"],"prefix":"10.25259","volume":"14","author":[{"given":"Joydeep Singh","family":"Vasant","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-5375","authenticated-orcid":false,"given":"Hemant","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Godara","sequence":"additional","affiliation":[{"name":"Department of Nephrology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumbhaj","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Punia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit Mohan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, M.G. Medical College, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"issue":"17","key":"ref1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/archinte.158.17.1889","article-title":"Renal failure in multiple myeloma: presenting features and predictors of outcome in 94 patients from a single institution","volume":"158","author":"J Blad\u00e9","year":"1998","journal-title":"Arch Intern Med"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"S V Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000442511","article-title":"Current trends of renal impairment in multiple myeloma","volume":"1","author":"P Yadav","year":"2016","journal-title":"Kidney Dis (Basel)"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.clml.2021.03.006","article-title":"A systematic review and network meta-analysis of randomized data on efficacy of novel therapy combinations in patients with lenalidomide-refractory multiple myeloma","volume":"21","author":"G R Mohyuddin","year":"2021","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/ndt\/gfp488","article-title":"Presentation and survival of patients with severe acute kidney injury and multiple myeloma: a 20-year experience from a single centre","volume":"25","author":"R J Haynes","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1016\/S1470-2045(23)00223-1","article-title":"Management of multiple 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in multiple myeloma","volume":"13","year":"2013","journal-title":"J Clin Oncol"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2215\/CJN.04590908","article-title":"Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis","volume":"4","author":"C A Hutchison","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/bmt.2011.8","article-title":"Renal failure in multiple myeloma: a medical emergency","volume":"46","author":"B Wirk","year":"2011","journal-title":"Bone Marrow Transplant"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-2141.1995.tb05400.x","article-title":"Patients with multiple myeloma requiring long-term dialysis: presenting features, response to therapy, and outcome in a series of 20 cases","volume":"91","author":"R Torra","year":"1995","journal-title":"Br J Haematol"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.clinthera.2006.06.009","article-title":"Bortezomib-dexamethasone combination in a patient with refractory multiple myeloma and impaired renal function","volume":"28","author":"A Nozza","year":"2006","journal-title":"Clin Ther"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1080\/10428190801930506","article-title":"Treatment of patients with multiple myeloma complicated by renal failure with bortezomib-based regimens","volume":"49","author":"M Roussou","year":"2008","journal-title":"Leuk Lymphoma"}],"container-title":["South Asian Journal of 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