{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:09:54Z","timestamp":1792087794027,"version":"4.4.0"},"reference-count":122,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian aging is characterized by fluctuations in reproductive hormones and determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process is essential for addressing health disparities, improving quality of life, and informing relevant public health strategies. This review synthesizes in vivo, in vitro, and epidemiological findings about the effects of endocrine-disrupting chemicals (EDCs), specifically heavy metals and perfluoroalkyl and polyfluoroalkyl substances (PFAS) on female reproductive aging. Most in vivo and in vitro studies have demonstrated that heavy metals alter ovarian morphology, folliculogenesis, and steroidogenesis. Evidence regarding the effects of PFAS is limited and inconsistent. Epidemiological studies have consistently shown that heavy metals are associated with a higher risk of diminished ovarian reserve (indicated by decreased anti-M\u00fcllerian hormone) and earlier menopause, with limited findings regarding reproductive hormone changes. PFAS exposure has been associated with decreased estradiol and earlier menopause but not significantly with ovarian reserve. Gaps in the literature require more comprehensive epidemiological research on the effects of EDCs on female reproductive aging, including ovarian reserve, age at menopause, and vasomotor symptoms, to inform future interventions to reduce hazardous exposures and improve women's health.<\/jats:p>","DOI":"10.1055\/s-0044-1801388","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:49:57Z","timestamp":1738194597000},"page":"330-360","source":"Crossref","is-referenced-by-count":12,"title":["Endocrine-Disrupting Chemicals and Female Reproductive Aging"],"prefix":"10.1055","volume":"42","author":[{"given":"Jiaxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siob\u00e1n D.","family":"Harlow","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John F.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen B.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of California Davis School of Medicine, Davis, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan"},{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/en.2012-1422","article-title":"Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society","volume":"153","author":"R T Zoeller","year":"2012","journal-title":"Endocrinology"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"E Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/endrev\/bnaa035","article-title":"Praegnatio perturbatio-impact of endocrine-disrupting chemicals","volume":"42","author":"V Padmanabhan","year":"2021","journal-title":"Endocr Rev"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S2213-8587(16)30275-3","article-title":"Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis","volume":"4","author":"T M Attina","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S2213-8587(20)30129-7","article-title":"Endocrine-disrupting chemicals: implications for human health","volume":"8","author":"L G Kahn","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"L N Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"issue":"02","key":"ref9","first-page":"259","article-title":"Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study","volume":"12","author":"L N Vandenberg","year":"2013","journal-title":"Dose Response"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"A143","DOI":"10.1289\/ehp.1205179","article-title":"Environmental chemicals: evaluating low-dose effects","volume":"120","author":"L S Birnbaum","year":"2012","journal-title":"Environ Health Perspect"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13048-024-01427-y","article-title":"Ovarian aging: energy metabolism of oocytes","volume":"17","author":"S Bao","year":"2024","journal-title":"J Ovarian Res"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/jc.2011-3362","article-title":"Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging","volume":"97","author":"S D Harlow","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/aogs.14253","article-title":"Can time to menopause be predicted?","volume":"100","author":"T G Tanbo","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/jama.2022.24140","article-title":"Management of menopausal symptoms: a review","volume":"329","author":"C J Crandall","year":"2023","journal-title":"JAMA"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ecl.2015.05.010","article-title":"Endocrinology of the menopause","volume":"44","author":"J E Hall","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"06","key":"ref16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00737-007-0209-5","article-title":"Understanding the pathophysiology of vasomotor symptoms (hot flushes and night sweats) that occur in perimenopause, menopause, and postmenopause life stages","volume":"10","author":"D C Deecher","year":"2007","journal-title":"Arch Womens Ment Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1477-7525-3-47","article-title":"Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review","volume":"3","author":"W H Utian","year":"2005","journal-title":"Health Qual Life Outcomes"},{"issue":"01","key":"ref18","first-page":"26","article-title":"Menopause and sleep disorders","volume":"13","author":"V R Tandon","year":"2022","journal-title":"J Midlife Health"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jsmc.2018.04.011","article-title":"Sleep and sleep disorders in the menopausal transition","volume":"13","author":"F C Baker","year":"2018","journal-title":"Sleep Med Clin"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/gme.0b013e3182730599","article-title":"Does risk for anxiety increase during the menopausal transition? Study of Women's Health Across the Nation","volume":"20","author":"J T Bromberger","year":"2013","journal-title":"Menopause"},{"issue":"09","key":"ref21","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1017\/S003329171100016X","article-title":"Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN)","volume":"41","author":"J T Bromberger","year":"2011","journal-title":"Psychol Med"},{"issue":"06","key":"ref22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archgenpsychiatry.2010.55","article-title":"Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition: results from the Study of Women's Health Across the Nation (SWAN)","volume":"67","author":"J T Bromberger","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/GME.0000000000001130","article-title":"Factors associated with developing vaginal dryness symptoms in women transitioning through menopause: a longitudinal study","volume":"25","author":"L E Waetjen","year":"2018","journal-title":"Menopause"},{"issue":"01","key":"ref24","first-page":"9","article-title":"Primary osteoporosis in postmenopausal women","volume":"1","author":"M X Ji","year":"2015","journal-title":"Chronic Dis Transl Med"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"101782","DOI":"10.1016\/j.beem.2023.101782","article-title":"Bone health and menopause: osteoporosis prevention and treatment","volume":"38","author":"T J de Villiers","year":"2024","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"25","key":"ref26","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1161\/CIR.0000000000000912","article-title":"Menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the American Heart Association","volume":"142","author":"S R El Khoudary","year":"2020","journal-title":"Circulation"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S1470-2045(12)70425-4","article-title":"Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies","volume":"13","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"2012","journal-title":"Lancet Oncol"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0028-2243(78)90014-X","article-title":"Age at menarche and menopause of uterine cancer patients","volume":"8","author":"J de Graaff","year":"1978","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"04","key":"ref29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.ede.0000165392.35273.d4","article-title":"Age at menopause, cause-specific mortality and total life expectancy","volume":"16","author":"M E Ossewaarde","year":"2005","journal-title":"Epidemiology"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ijc.2910490111","article-title":"Pooled analysis of 3 European case-control studies of ovarian cancer: II. Age at menarche and at menopause","volume":"49","author":"S Franceschi","year":"1991","journal-title":"Int J Cancer"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"N Ding","year":"2020","journal-title":"Hum Reprod Update"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/13697137.2023.2173570","article-title":"Does the environment affect menopause? A review of the effects of endocrine disrupting chemicals on menopause","volume":"26","author":"L Levine","year":"2023","journal-title":"Climacteric"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"119269","DOI":"10.1016\/j.envpol.2022.119269","article-title":"Endocrine disrupting chemicals impact on ovarian aging: evidence from epidemiological and experimental evidence","volume":"305","author":"T Ding","year":"2022","journal-title":"Environ Pollut"},{"key":"ref34","volume-title":"Trace Elements in Human Nutrition and Health","author":"FAO. Weltgesundheitsorganisation, Internationale Atomenergie-Organisation, eds","year":"1996"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40572-023-00402-x","article-title":"A state-of-the-science review on metal biomarkers","volume":"10","author":"I Martinez-Morata","year":"2023","journal-title":"Curr Environ Health Rep"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/enrs.1997.3810","article-title":"Blood lead-urine lead relationships in adults and children","volume":"78","author":"B L Gulson","year":"1998","journal-title":"Environ Res"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/jes.2013.4","article-title":"Investigation of lead concentrations in whole blood, plasma and urine as biomarkers for biological monitoring of lead exposure","volume":"24","author":"J N Sommar","year":"2014","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"105324","DOI":"10.1016\/j.envint.2019.105324","article-title":"Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma","volume":"137","author":"M Forsthuber","year":"2020","journal-title":"Environ Int"},{"issue":"21","key":"ref40","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1021\/acs.est.2c09852","article-title":"Self-collection blood test for PFASs: comparing volumetric microsamplers with a traditional serum approach","volume":"57","author":"C C Carignan","year":"2023","journal-title":"Environ Sci Technol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"824921","DOI":"10.3389\/fnagi.2022.824921","article-title":"Integrating environment and aging research: opportunities for synergy and acceleration","volume":"14","author":"K MC Malecki","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"ref42","first-page":"95","article-title":"The elderly as a sensitive population in environmental exposures: making the case","volume":"207","author":"J F Risher","year":"2010","journal-title":"Rev Environ Contam Toxicol"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/jgs.2000.48.11.1501","article-title":"Lead toxicity in older adults","volume":"48","author":"E K Vig","year":"2000","journal-title":"J Am Geriatr Soc"},{"issue":"05","key":"ref44","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1377\/hlthaff.2011.0153","article-title":"Understanding the cumulative impacts of inequalities in environmental health: implications for policy","volume":"30","author":"R Morello-Frosch","year":"2011","journal-title":"Health Aff (Millwood)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"100959","DOI":"10.1016\/j.ssmph.2021.100959","article-title":"Racial and ethnic inequities in occupational exposure across and between US cities","volume":"16","author":"A S Schnake-Mahl","year":"2021","journal-title":"SSM Popul Health"},{"issue":"03","key":"ref46","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12291-016-0610-9","article-title":"Lead as a risk factor for osteoporosis in post-menopausal women","volume":"32","author":"A Manocha","year":"2017","journal-title":"Indian J Clin Biochem"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3390\/ijms22041568","article-title":"Critical role of estrogens on bone homeostasis in both male and female: from physiology to medical implications","volume":"22","author":"N E Emmanuelle","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"15","key":"ref48","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1021\/es500796y","article-title":"Enhanced elimination of perfluorooctane sulfonic acid by menstruating women: evidence from population-based pharmacokinetic modeling","volume":"48","author":"F Wong","year":"2014","journal-title":"Environ Sci Technol"},{"issue":"02","key":"ref53","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3906\/biy-1407-6","article-title":"Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes","volume":"39","author":"E Dumitrescu","year":"2015","journal-title":"Turk J Biol"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0971-6580.68340","article-title":"Toxicological approach in chronic exposure to lead on reproductive functions in female rats (Rattus norvegicus)","volume":"17","author":"V Dhir","year":"2010","journal-title":"Toxicol Int"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"111231","DOI":"10.1016\/j.ecoenv.2020.111231","article-title":"Lead exposure activates the Nrf2\/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice","volume":"207","author":"X Jiang","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"issue":"09","key":"ref56","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/toxics11090769","article-title":"Lead exposure assessment and its impact on the structural organization and morphological peculiarities of rat ovaries","volume":"11","author":"A Osowski","year":"2023","journal-title":"Toxics"},{"issue":"05","key":"ref57","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3906\/biy-1402-50","article-title":"Reproductive biology study of dynamics of female sexual hormones: a 12-month exposure to lead acetate rat model","volume":"38","author":"E Dumitrescu","year":"2014","journal-title":"Turk J Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6490820","DOI":"10.1155\/2019\/6490820","article-title":"Subchronic exposure to cadmium causes persistent changes in the reproductive system in female Wistar rats","volume":"2019","author":"M Nasiadek","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.reprotox.2020.01.002","article-title":"Anti-M\u00fcllerian hormone participates in ovarian granulosa cell damage due to cadmium exposure by negatively regulating stem cell factor","volume":"93","author":"N Chen","year":"2020","journal-title":"Reprod Toxicol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"116154","DOI":"10.1016\/j.envpol.2020.116154","article-title":"Subacute cadmium exposure disrupts the hypothalamic-pituitary-gonadal axis, leading to polycystic ovarian syndrome and premature ovarian failure features in female rats","volume":"269","author":"C S da Costa","year":"2021","journal-title":"Environ Pollut"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12011-013-9650-7","article-title":"NF-\u03baB pathway contributes to cadmium-induced apoptosis of porcine granulosa cells","volume":"153","author":"C Wang","year":"2013","journal-title":"Biol Trace Elem Res"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12906-020-02960-1","article-title":"Protective effect of Tualang honey against cadmium-induced morphological abnormalities and oxidative stress in the ovary of rats","volume":"20","author":"S S Ruslee","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/biolre\/ioaa091","article-title":"MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium\u2020","volume":"103","author":"P Zhong","year":"2020","journal-title":"Biol Reprod"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.reprotox.2020.06.009","article-title":"Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor","volume":"96","author":"F Dong","year":"2020","journal-title":"Reprod Toxicol"},{"issue":"04","key":"ref65","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jog.12911","article-title":"Effect of mercury vapor inhalation on rat ovary: stereology and histopathology","volume":"42","author":"B Z Altunkaynak","year":"2016","journal-title":"J Obstet Gynaecol Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxlet.2019.05.006","article-title":"Mercury leads to features of polycystic ovary syndrome in rats","volume":"312","author":"E Merlo","year":"2019","journal-title":"Toxicol Lett"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3109\/13880209.2013.792846","article-title":"Prevention of arsenic-mediated reproductive toxicity in adult female rats by high protein diet","volume":"51","author":"S Mondal","year":"2013","journal-title":"Pharm Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.toxrep.2018.02.003","article-title":"The consequence of NAC on sodium arsenite-induced uterine oxidative stress","volume":"5","author":"M Dash","year":"2018","journal-title":"Toxicol Rep"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"113816","DOI":"10.1016\/j.ecoenv.2022.113816","article-title":"Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation","volume":"241","author":"Y Chen","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"issue":"02","key":"ref70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/01.EHX.0000446582.73701.1b","article-title":"Arsenic-induced toxicity in the endometrium of adult albino rat and the possible role of human chorionic gonadotropin hormone: a histological study","volume":"37","author":"A M Elshawarby","year":"2014","journal-title":"Egypt J Histol"},{"issue":"01","key":"ref71","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/19338244.2014.927346","article-title":"Effect of sodium arsenite on reproductive organs of female Wistar rats","volume":"71","author":"M Mehta","year":"2016","journal-title":"Arch Environ Occup Health"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-023-03988-3","article-title":"Arsenic-induced thyroid hormonal alterations and their putative influence on ovarian follicles in Balb\/c mice","author":"K Nandheeswari","journal-title":"Biol Trace Elem Res"},{"issue":"08","key":"ref73","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.chemosphere.2013.01.012","article-title":"Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays","volume":"91","author":"G Du","year":"2013","journal-title":"Chemosphere"},{"issue":"02","key":"ref74","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/toxsci\/kfac005","article-title":"Perfluorooctanoic acid disrupts ovarian steroidogenesis and folliculogenesis in adult mice","volume":"186","author":"M Yang","year":"2022","journal-title":"Toxicol Sci"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/etc.2034","article-title":"Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo","volume":"32","author":"G Du","year":"2013","journal-title":"Environ Toxicol Chem"},{"issue":"02","key":"ref76","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfv197","article-title":"Chronic exposure of female mice to an environmental level of perfluorooctane sulfonate suppresses estrogen synthesis through reduced histone H3K14 acetylation of the StAR promoter leading to deficits in follicular development and ovulation","volume":"148","author":"X Feng","year":"2015","journal-title":"Toxicol Sci"},{"issue":"02","key":"ref77","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1530\/REP-21-0022","article-title":"Mechanisms of ovarian aging","volume":"162","author":"S U Park","year":"2021","journal-title":"Reproduction"},{"issue":"02","key":"ref78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmig.2016.12.010","article-title":"Impact of cystectomy on ovarian reserve: review of the literature","volume":"24","author":"R Alammari","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"issue":"02","key":"ref79","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0015-0282(01)02993-4","article-title":"Antim\u00fcllerian hormone serum levels: a putative marker for ovarian aging","volume":"77","author":"A de Vet","year":"2002","journal-title":"Fertil 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Wang","year":"2021","journal-title":"Environ Int"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/1471-2458-14-419","article-title":"Relationship between arsenic skin lesions and the age of natural menopause","volume":"14","author":"F M Yunus","year":"2014","journal-title":"BMC Public Health"},{"issue":"02","key":"ref105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1289\/ehp.1306707","article-title":"Polyfluoroalkyl chemicals and menopause among women 20-65 years of age (NHANES)","volume":"122","author":"K W Taylor","year":"2014","journal-title":"Environ Health Perspect"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.envres.2015.12.037","article-title":"Perfluorooctanoic acid exposure and natural menopause: a longitudinal study in a community cohort","volume":"146","author":"R Dhingra","year":"2016","journal-title":"Environ 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