{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:15:42Z","timestamp":1747455342052,"version":"3.40.5"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Plast Surg"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Any deviation from the normal process of wound healing leads to excessive scar formation in the form of keloid or hypertrophic scar.<\/jats:p><jats:p>\n          Materials and Methods\u2003The study included 120 candidates with keloids divided equally into two groups, A and B, of 60 patients each. After surgical excision, group A received combination therapy of intramarginal 5-fluorouracil (5-FU) and triamcinolone acetonide (TCA), while group B received only TCA, followed by compression therapy in both.<\/jats:p><jats:p>\n          Results\u2003Eighty-seven patients had keloids on ear lobules, 25 (20.8%) on helix, and 8 (6.7%) over multiple locations on ear. Ninety-two (76.7%) had keloids over bilateral, 18 (15%) on left, and 10 (8.3%) on right ear. Sixty-three (52.5%) belonged to third, 65 (54.2%) to fourth, and 8 (6.7%) to fifth decade of life. Overall recurrence rate was 21.7 and 38.3% in group A and B, respectively. Recurrence was seen in 2 from group A (male:female 2:0) and 4 from group B (male:female 3:1) at 3 months, in 7 from group A (male:female 5:2) and 13 in group B (male:female 8:5) at 6 months, and in 4 from group A (male:female 3:1) and 6 from group B (male:female 5:1) at 1 year. Overall, pain was reported by 9 and 7 from group A and B, respectively, and burning sensation by 3 and 1 from group A and B, respectively. Ulceration was noted in 2, wound dehiscence in 1 and transient hyperpigmentation in 2 from group A. Based on the Vancouver Scar Scale, outcome on follow-up had an average of 3.5 at 3 months, 4.2 at 6 months, and 4.8 at 1 year in group A, and 3.8 at 3 months, 4.7 at 6 months, and 5.4 at 1 year in group B.<\/jats:p><jats:p>\n          Conclusion\u2003Multimodal approach of combination therapy of intramarginal 5-FU and TCA with compression therapy after surgical excision of keloids in ears yields lower recurrence rate when compared with TCA alone. Chances of recurrence are more common in males than females. Though intramarginal 5-FU in combination with TCA has more localized side effects than TCA alone yet lower recurrence rate and better results in the long term can overcome the mild severity of these side effects.<\/jats:p>","DOI":"10.1055\/s-0044-1801403","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:14:21Z","timestamp":1737159261000},"page":"105-109","source":"Crossref","is-referenced-by-count":0,"title":["Combination Therapy of 5-Fluorouracil and Triamcinolone Acetonide with Compression Therapy after Surgical Excision in the Management of Keloids in Ears"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-8653","authenticated-orcid":false,"given":"Randeep Singh","family":"Lamba","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-3166","authenticated-orcid":false,"given":"Pinki","family":"Pargal","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Salwan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junaise","family":"P.M","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallavi","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noopur","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Christian Medical College, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"03","key":"ref1","first-page":"17","article-title":"Treatment of small keloids using intralesional 5-fluorouracil and triamcinolone acetonide versus intralesional bleomycin and triamcinolone acetonide","volume":"14","author":"S Sharma","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref2","first-page":"27","volume-title":"Bailey & Love's Short Practice of Surgery","author":"S L Benyon","year":"2023","edition":"28th ed."},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-0029-1224797","article-title":"Keloids: pathogenesis, clinical features, and management","volume":"23","author":"C J Chike-Obi","year":"2009","journal-title":"Semin Plast Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2147\/CCID.S133672","article-title":"Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives","volume":"11","author":"M Morelli Coppola","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"e5864","DOI":"10.1097\/GOX.0000000000005864","article-title":"Compression therapy for keloid scars: a systematic review and meta-analysis","volume":"12","author":"S M Tahir","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00000637-197811000-00008","article-title":"The role of pressure therapy in management of earlobe keloids: preliminary report of a 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sheeting for hypertrophic and keloid scar treatment and management","volume":"33","author":"B Berman","year":"2007","journal-title":"Dermatol Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"tkaa031","DOI":"10.1093\/burnst\/tkaa031","article-title":"Assessing keloid recurrence following surgical excision and radiation","volume":"8","author":"M H Gold","year":"2020","journal-title":"Burns Trauma"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1524-4725.1999.08165.x","article-title":"Treatment of inflamed hypertrophic scars using intralesional 5-FU","volume":"25","author":"R E Fitzpatrick","year":"1999","journal-title":"Dermatol Surg"},{"issue":"07","key":"ref13","first-page":"778","article-title":"Intralesional 5-fluorouracil in keloid treatment: a systematic review","volume":"95","author":"E Bijlard","year":"2015","journal-title":"Acta Derm 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