{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T04:40:22Z","timestamp":1774759222750,"version":"3.50.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to compare the analgesic effects of intermittent multiple infiltrations between the popliteal artery and capsule of the posterior knee (IPACK) combined with adductor canal block (ACB) and intermittent ACB alone in patients with flexion contracture knee arthritis undergoing total knee arthroplasty (TKA). Forty-six patients who underwent elective unilateral TKA were divided into two groups (n\u2009=\u200923 each): intermittent multiple IPACK combined with ACB (group IA) and intermittent multiple ACB (group A). ACB was performed with 20\u2009mL of 0.375% ropivacaine in each group and IPACK with 20\u2009mL of 0.25% ropivacaine in group IA. Intermittent multiple nerve blocks were used for postoperative analgesia (IPACK block combined with ACB in group IA and ACB in group A between 7:30 and 8:30 a.m. on postoperative day 1 [POD1] and postoperative day 2 [POD2]). Primary outcomes assessed were pain at rest, motion-evoked pain (MEP), and range of motion (ROM) on POD1 and POD2. Secondary outcomes included opioid consumption, first ambulation time, ambulation distance, and postoperative complications. We observed that compared with group A, MEP decreased, ROM became wider, ambulation distance was longer, and opioid consumption decreased in group IA. Other outcomes were either similar between the groups or showed clinically insignificant differences. We conclude that multiple intermittent IPACK therapy combined with ACB provides superior analgesia than multiple intermittent ACB therapy alone in patients with flexion contracture knee arthritis undergoing TKA.<\/jats:p>","DOI":"10.1055\/s-0044-1801822","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:30:53Z","timestamp":1737419453000},"page":"316-322","source":"Crossref","is-referenced-by-count":2,"title":["Analgesic Effect of Intermittent Multiple IPACK Block Combined with ACB in Patients with Flexion Contracture Knee Arthritis Undergoing Total Knee Arthroplasty"],"prefix":"10.1055","volume":"38","author":[{"given":"Yuqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of Jilin University, Changchun, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouhui","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of Jilin University, Changchun, People's Republic of China"},{"name":"Department of Anesthesiology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of Jilin University, Changchun, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of Jilin University, Changchun, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of Jilin University, Changchun, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/joacp.JOACP_198_18","article-title":"A comparative analysis of femoral nerve block with adductor canal block following total knee arthroplasty: a systematic literature review","volume":"34","author":"Y Karkhur","year":"2018","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1007\/s00167-018-5161-6","article-title":"Modern TKA implants are equivalent to traditional TKA implants in functional and patellofemoral joint-related outcomes","volume":"27","author":"J L Chua","year":"2019","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5792\/ksrr.16.039","article-title":"Femoral nerve block versus 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