{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:50:56Z","timestamp":1773229856024,"version":"3.50.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study is to (1) estimate and compare the prevalence of venous thromboembolism (VTE) in children (age 0 to \u226421) with versus without cystic fibrosis (CF); (2) investigate putative associations between specific gastrointestinal (GI) manifestations and the development of VTE among children with CF. This was a multicenter case\u2013control analysis among patients aged 0 to \u2264 21 years between 2010 and 2020, using the TriNetX Research Network. Data queries included ICD-9\/10 (International Classification of Diseases-9th\/10th Revision) diagnosis codes. Bivariate associations with VTE among CF patients were compared using Chi-square testing for categorical variables and Student's t-test for continuous variables. We used multivariable logistic regression to test for independent associations of GI manifestations with VTE among children with CF, with adjustment for other salient covariates. There was a total of 7,689 children with and 22,327,660 without CF. The frequency of occurrence of VTE was increased nearly 20-fold among those with, as compared with without CF (130 vs. 7 per 10,000 patients). Acute pancreatitis (adjusted odd ratio [aOR]\u2009=\u20093.80, [95% confidence interval, CI: 2.00\u20137.22]), biliary disease (aOR\u2009=\u20092.17 [95% CI: 1.17\u20134.03]), gastrostomy status (aOR\u2009=\u20092.01 [95% CI: 1.27\u20133.18]), and malabsorption\/malnutrition (aOR\u2009=\u20092.41 [95% CI: 1.52\u20133.82]) were each associated with a higher likelihood of VTE among children with CF. In conclusion, we found a significantly increased frequency of VTE occurrence and association of specific GI diseases as independent risk factors for VTE among children with CF compared with those without.<\/jats:p>","DOI":"10.1055\/s-0044-1801825","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T18:46:37Z","timestamp":1736793997000},"page":"736-744","source":"Crossref","is-referenced-by-count":3,"title":["Venous Thromboembolism Occurrence and Association with Gastrointestinal Disorders in Children with Cystic Fibrosis: An Analysis from the TriNetX Research Network Global Multicenter Real-World Dataset"],"prefix":"10.1055","volume":"51","author":[{"given":"Carolena","family":"Trocchia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Lucille Packard Children's Hospital of Stanford, Palo Alto, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Ashour","sequence":"additional","affiliation":[{"name":"Epidemiology\/Biostatistics Unit, Johns Hopkins All Children's Hospital and Johns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maua","family":"Mosha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, University of South Florida Morsani College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailey","family":"Hamner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, University of South Florida Morsani College of Medicine, Tampa, Florida"},{"name":"Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Betensky","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department Research, Johns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Racha","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, University of South Florida Morsani College of Medicine, Tampa, Florida"},{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, 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