{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T18:05:16Z","timestamp":1776621916005,"version":"3.51.2"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Parkinson's disease (PD) is a degenerative, progressive, chronic disease that mainly affects the central nervous system, caused by dopamine deficiency. One of the ways to evaluate the central nervous system is with auditory evoked potentials (AEP).<\/jats:p><jats:p>\n          Objective\u2003To characterize the audiometric responses, and the auditory brainstem response (ABR), and cortical auditory evoked potentials (CAEP) in individuals with PD.<\/jats:p><jats:p>\n          Methods\u2003Thirty-two patients aged between 40 and 81 of both sexes were assessed, 16 with PD (study group [SG]) and 16 without PD (control group [CG]) matched for sex and age. The subjects were assessed using pure tone audiometry, ABR with click stimuli, and CAEP using the oddball paradigm with tone burst and speech stimuli. The results were compared between the groups using a repeated measures analysis of variance (ANOVA) test.<\/jats:p><jats:p>\n          Results\u2003In pure-tone audiometry, significantly higher hearing thresholds were found in the SG at 6 and 8\u2009kHz. For the ABR, no differences were observed between groups. The CAEP analysis did not find statistical differences in the latencies between the groups, however, the SG presented smaller amplitudes of P1-N1, P2-N2, and N2-P3 than the CG.<\/jats:p><jats:p>\n          Conclusion\u2003The results of this study showed a significantly higher threshold in higher frequencies in PD. Although no differences were observed at the brainstem level, the decrease in amplitude of all components in patients with PD in the CAEP suggests a deficit in both automatic and attentional cortical processing of acoustic stimuli.<\/jats:p>","DOI":"10.1055\/s-0045-1801844","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:52:46Z","timestamp":1738889566000},"page":"001-011","source":"Crossref","is-referenced-by-count":1,"title":["Auditory pathway abnormalities in Parkinson's disease"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-0096","authenticated-orcid":false,"given":"Rafaela Valiengo de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-0447","authenticated-orcid":false,"given":"Liliane Aparecida Fagundes","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-7172","authenticated-orcid":false,"given":"Carla Gentile","family":"Matas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"04","key":"ref1","first-page":"897","article-title":"Epidemiological transition and the study of burden of disease in Brazil","volume":"9","author":"J MA Schramm","year":"2004","journal-title":"Cien Saude Colet"},{"issue":"06","key":"ref2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"L M de Lau","year":"2006","journal-title":"Lancet Neurol"},{"issue":"04","key":"ref3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1590\/S0034-72992002000400003","article-title":"Auditory central avaliation in Parkinson Disease with BERA and P300","volume":"68","author":"J CA Pineroli","year":"2002","journal-title":"Braz J Otorhinolaryngol"},{"issue":"02","key":"ref4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1176\/jnp.14.2.223","article-title":"An essay on the shaking palsy. 1817","volume":"14","author":"J Parkinson","year":"2002","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"01","key":"ref5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1590\/S0004-282X2003000100011","article-title":"Tratamento dos dist\u00farbios da voz na doen\u00e7a de Parkinson: o m\u00e9todo Lee Silverman","volume":"61","author":"A E Dias","year":"2003","journal-title":"Arq Neuropsiquiatr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1468-1331.2008.02056.x","article-title":"Non-motor symptoms in Parkinson's disease","volume":"15","author":"W Poewe","year":"2008","journal-title":"Eur J Neurol"},{"issue":"05","key":"ref7","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","article-title":"Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment","volume":"8","author":"K R Chaudhuri","year":"2009","journal-title":"Lancet Neurol"},{"issue":"11","key":"ref8","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1002\/mds.23826","article-title":"Do nonmotor symptoms in Parkinson's disease differ from normal aging?","volume":"26","author":"S Krishnan","year":"2011","journal-title":"Mov Disord"},{"issue":"01","key":"ref9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson's disease-related pathology","volume":"318","author":"H Braak","year":"2004","journal-title":"Cell Tissue Res"},{"issue":"08","key":"ref10","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.parkreldis.2015.06.007","article-title":"An investigation of hearing impairment in de-novo Parkinson's disease patients: A preliminary study","volume":"21","author":"V Pisani","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"G Livingston","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"ref12","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1002\/mds.25149","article-title":"Hearing impairment in Parkinson's disease: expanding the nonmotor phenotype","volume":"27","author":"C Vitale","year":"2012","journal-title":"Mov Disord"},{"issue":"03","key":"ref13","first-page":"319","article-title":"Altera\u00e7\u00f5es auditivas em indiv\u00edduos com doen\u00e7a de Parkinson","volume":"13","author":"M B Rabelo","year":"2014","journal-title":"Rev Ci\u00eanc M\u00e9d Biol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"S138","DOI":"10.1016\/j.parkreldis.2015.09.040","article-title":"Speech discrimination is impaired in parkinsonian patients: Expanding the audiologic findings of Parkinson's disease","volume":"22","author":"C Vitale","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"ref15","volume-title":"Fun\u00e7\u00e3o coclear na doen\u00e7a de Parkinson. Disserta\u00e7\u00e3o (Mestrado em Ci\u00eancias da Reabilita\u00e7\u00e3o) - Faculdade de Medicina","author":"M S Leme","year":"2021"},{"issue":"01","key":"ref16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.parkreldis.2015.09.040","article-title":"Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's disease","volume":"68","author":"C RG Jones","year":"2008","journal-title":"Brain Cogn"},{"issue":"01","key":"ref17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.bbr.2011.07.019","article-title":"The function of dopaminergic neural signal transmission in auditory pulse perception: evidence from dopaminergic treatment in Parkinson's patients","volume":"225","author":"E Geiser","year":"2011","journal-title":"Behav Brain Res"},{"key":"ref18","volume-title":"New handbook of auditory evoked responses","author":"J Hall","year":"2006"},{"issue":"04","key":"ref19","doi-asserted-by":"publisher","first-page":"492","DOI":"10.9771\/cmbio.v12i4.9199","article-title":"Potenciais evocados auditivos do tronco encef\u00e1lico na doen\u00e7a de Parkinson: revis\u00e3o sistem\u00e1tica","volume":"12","author":"M S Lopes","year":"2013","journal-title":"Rev Ci\u00eanc M\u00e9d Biol"},{"issue":"04","key":"ref20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1001\/archotol.1970.04310040005002","article-title":"Clinical experience with impedance audiometry","volume":"92","author":"J Jerger","year":"1970","journal-title":"Arch Otolaryngol"},{"key":"ref21","first-page":"44","volume-title":"Basic Audiol\u00f3gic Testing","author":"S Silman","year":"1997"},{"issue":"01","key":"ref22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1590\/S0004-282X1995000100001","article-title":"Tratamento da Doen\u00e7a de Parkinson","volume":"7","author":"H B Ferraz","year":"1999","journal-title":"Rev Neurocienc"},{"issue":"12","key":"ref23","doi-asserted-by":"publisher","first-page":"115963","DOI":"10.34117\/bjdv7n12-384","article-title":"Epidemiological profile of people with Parkinson's disease","volume":"7","author":"A CCR Clementino","year":"2021","journal-title":"BJS"},{"issue":"05","key":"ref24","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00405-009-0933-8","article-title":"Auditory evaluation in Parkinsonian patients","volume":"266","author":"S Y\u00fdlmaz","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"02","key":"ref25","doi-asserted-by":"publisher","first-page":"fcaa144","DOI":"10.1093\/braincomms\/fcaa144","article-title":"Lateralization of cochlear dysfunction as a specific biomarker of Parkinson's disease","volume":"2","author":"R Sisto","year":"2020","journal-title":"Brain Commun"},{"issue":"02","key":"ref26","doi-asserted-by":"publisher","first-page":"fcad075","DOI":"10.1093\/braincomms\/fcad075","article-title":"Association between hearing sensitivity and dopamine transporter availability in Parkinson's disease","volume":"5","author":"E Garasto","year":"2023","journal-title":"Brain Commun"},{"issue":"02","key":"ref27","doi-asserted-by":"publisher","first-page":"84","DOI":"10.14802\/jmd.18048","article-title":"Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson's Disease","volume":"12","author":"K Shetty","year":"2019","journal-title":"J Mov Disord"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.parkreldis.2020.01.018","article-title":"A comparison of auditory and vestibular dysfunction in Parkinson's disease and Multiple System Atrophy","volume":"71","author":"A Scarpa","year":"2020","journal-title":"Parkinsonism Relat Disord"},{"issue":"01","key":"ref29","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1523\/JNEUROSCI.4720-11.2012","article-title":"Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes","volume":"32","author":"S F Maison","year":"2012","journal-title":"J Neurosci"},{"issue":"06","key":"ref30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1159\/000275954","article-title":"Brainstem auditory evoked potentials with and without increased stimulus rate as diagnostic tool in brainstem minor transient changes","volume":"49","author":"L Podoshin","year":"1987","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"04","key":"ref31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000116262","article-title":"Brainstem auditory evoked potentials to different stimulus rates in parkinsonian patients","volume":"28","author":"M Fradis","year":"1988","journal-title":"Eur Neurol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/00207458908986210","article-title":"Short-latency somatosensory and brainstem auditory evoked potentials in patients with Parkinson's disease","volume":"44","author":"H Tachibana","year":"1989","journal-title":"Int J Neurosci"},{"issue":"05","key":"ref33","doi-asserted-by":"publisher","first-page":"e00703","DOI":"10.1002\/brb3.703","article-title":"Evoked potential changes in patients with Parkinson's disease","volume":"7","author":"C Liu","year":"2017","journal-title":"Brain Behav"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fneur.2017.00055","article-title":"Auditory-and Vestibular-Evoked Potencials Correlate with Motor and Nom-Motor Features of Parkinson's Disease","volume":"8","author":"A S Shalash","year":"2017","journal-title":"Front Neurol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuropsychologia.2014.07.016","article-title":"Novelty processing and memory formation in Parkinson's disease","volume":"62","author":"J Schomaker","year":"2014","journal-title":"Neuropsychologia"},{"issue":"11","key":"ref36","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.clinph.2014.12.024","article-title":"The P3a wave: A reliable neurophysiological measure of Parkinson's disease duration and severity","volume":"126","author":"R Sol\u00eds-Vivanco","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"05","key":"ref37","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.clinph.2019.01.017","article-title":"Central fatigue and attentional processing in Parkinson's disease: An event-related potentials study","volume":"130","author":"C Pauletti","year":"2019","journal-title":"Clin Neurophysiol"},{"issue":"04","key":"ref38","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mds.28000","article-title":"Auditory Dysfunction in Parkinson's Disease","volume":"35","author":"Z Jafari","year":"2020","journal-title":"Mov Disord"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.actpsy.2015.02.001","article-title":"Dopaminergic medication alters auditory distractor processing in Parkinson's disease","volume":"156","author":"D Georgiev","year":"2015","journal-title":"Acta Psychol (Amst)"},{"issue":"02","key":"ref40","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1590\/S1516-18462009000600015","article-title":"Characterizing cognitive disorders in Parkinson's disease","volume":"11","author":"M MAMC Galhardo","year":"2009","journal-title":"Rev CEFAC"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0045-1801844.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:52:49Z","timestamp":1738889569000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0045-1801844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,1,15]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["s00451801844"],"URL":"https:\/\/doi.org\/10.1055\/s-0045-1801844","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}